INT62545

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 14.26
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
endothelial cells 8
retinas 2
brains 2
lungs 2
kidney 2
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 28 99.36 Very High Very High Very High
dexamethasone 5 99.32 Very High Very High Very High
ischemia 53 99.20 Very High Very High Very High
chemokine 110 98.96 Very High Very High Very High
cytokine 81 94.88 High High
Angina 13 93.60 High High
aspirin 312 92.64 High High
Inflammation 278 90.32 High High
Inflammatory response 17 87.60 High High
medulla 5 86.04 High High
Disease Link Frequency Relevance Heat
Adhesions 136 100.00 Very High Very High Very High
Cancer 40 100.00 Very High Very High Very High
Necrosis 20 100.00 Very High Very High Very High
Viral Meningitis 26 99.76 Very High Very High Very High
Injury 197 99.64 Very High Very High Very High
Coronary Heart Disease 36 99.64 Very High Very High Very High
Burns 36 99.40 Very High Very High Very High
Brain Hemorrhage 3 99.20 Very High Very High Very High
INFLAMMATION 288 99.16 Very High Very High Very High
Myocardial Infarction 26 98.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, modulation of intercellular adhesion molecule-1 expression by glucocorticoids is an effect independent endogenous lipocortin 1, and it is an in vivo feature of these potent anti-inflammatory drugs.
Regulation (modulation) of Gene_expression (expression) of intercellular adhesion molecule-1 associated with inflammation, cinod and adhesions
1) Confidence 0.49 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8660354 Disease Relevance 0.51 Pain Relevance 0.31
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Regulation (verified) of Gene_expression (expression) of ICAM-1
2) Confidence 0.41 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.58 Pain Relevance 0.47
Previous studies compared ICAM-1 K469E polymorphisms between MI and CHD group as a whole.714 In our work, there were no significant differences in sICAM-1 levels between CHD patients and control subjects (P=.37) and no significant differences in sICAM-1 levels among patients with different genotypes (P=.53).
Neg (no) Regulation (differences) of Gene_expression (levels) of sICAM-1 associated with coronary heart disease and myocardial infarction
3) Confidence 0.39 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.15 Pain Relevance 0.09
The ICAM-1 expression was determined in all the animals used in this study.
Spec (determined) Regulation (determined) of Gene_expression (expression) of ICAM-1
4) Confidence 0.39 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.24 Pain Relevance 0
Immunohistochemistry for ICAM-1 expression and neutrophil sequestration
Regulation (Immunohistochemistry) of Gene_expression (expression) of ICAM-1 in neutrophil
5) Confidence 0.39 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.16 Pain Relevance 0.03
B-regulated expression of Tnf, Il6, Ccl2, Ccl5, Cxcl10, and Icam1 [22] were significantly reduced in Tlr4 KO versus WT retinas, suggesting that the neuroprotective effect is in part due to Tlr4-NF-?
Regulation (regulated) of Gene_expression (expression) of Icam1 in retinas
6) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.98 Pain Relevance 0.35
There was no effect of the drugs on the percentage of endothelial cells expressing ICAM-1 (Figure 4C).
Neg (no) Regulation (effect) of Gene_expression (expressing) of ICAM-1 in endothelial cells
7) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.05 Pain Relevance 0.21
Effect of CORM-2 on expressions of HO-1 and ICAM-1 (Western Blot) in the kidney of thermally injured mice
Regulation (Effect) of Gene_expression (expressions) of ICAM-1 in kidney
8) Confidence 0.33 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.63 Pain Relevance 0
High dose ASA, but not NCX 4016, inhibited endothelial cell expression of VCAM-1 and thrombomodulin in the carotid arteries at 4 weeks after irradiation; eNOS and ICAM-1 levels were unchanged.
Neg (unchanged) Regulation (unchanged) of Gene_expression (levels) of ICAM-1 in endothelial cell
9) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943480 Disease Relevance 0.50 Pain Relevance 0.26
0.019) (Figure 4B) and there was a trend for decreased ICAM-1 expression around and above the bifurcation compared with below the bifurcation (p?
Regulation (trend) of Gene_expression (expression) of ICAM-1
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.21 Pain Relevance 0.30
0.019) (Figure 4B) and there was a trend for decreased ICAM-1 expression around and above the bifurcation compared with below the bifurcation (p?
Regulation (around) of Gene_expression (expression) of ICAM-1
11) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.21 Pain Relevance 0.28
Rebamipide reduces indomethacin-induced gastric injury in mice via down-regulation of ICAM-1 expression.
Regulation (regulation) of Gene_expression (expression) of ICAM-1 associated with injury
12) Confidence 0.27 Published 2005 Journal Dig. Dis. Sci. Section Title Doc Link 16184426 Disease Relevance 0.83 Pain Relevance 0.29
Absence of 5-LO-derived mediators did not alter the expression of the adhesion molecules ICAM-1 and P-selectin.
Neg (not) Regulation (alter) of Gene_expression (expression) of ICAM-1 associated with adhesions
13) Confidence 0.24 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18048478 Disease Relevance 0.87 Pain Relevance 0.66
Therefore, insufficient expression of ICAM-1, KC, and MIP-2 was not responsible for the effect of p50 deficiency on neutrophil recruitment elicited by LPS in the lungs.
Neg (not) Regulation (responsible) of Gene_expression (expression) of ICAM-1 in lungs
14) Confidence 0.16 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.25 Pain Relevance 0.29
In addition, hypothermic temperatures were found associated with increased P-selectin shedding, although cardiopulmonary bypass patients did not reveal differences in circulating levels of ICAM-1 and VCAM-1 during normothermia and hypothermia [20].
Regulation (circulating) of Gene_expression (levels) of ICAM-1 associated with hypothermia
15) Confidence 0.15 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.88 Pain Relevance 0.14
The expression of interleukin-1 (IL-1 beta, IL-6, IL-10), tumor necrosis factors-alpha (TNF alpha), vascular endothelial growth factor (VEGF), and adhesion molecules (E-selectin, intracellular cell adhesion molecule (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1)) in encephalitic brains of mice and humans was evaluated by semi-quantitative polymerase chain reaction (PCR).
Regulation (evaluated) of Gene_expression (expression) of ICAM-1 in brains associated with necrosis, cancer and adhesions
16) Confidence 0.14 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9475112 Disease Relevance 2.43 Pain Relevance 0.18
Astrocytes apparently control expression of ICAM-1 in endothelial cells of the BBB, and upon exposure to TNF-?
Regulation (control) of Gene_expression (expression) of ICAM-1 in endothelial cells
17) Confidence 0.13 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.57 Pain Relevance 0.09
Shen and co-workers (1996) have shown that cigarette smoke condensate induces the expression of a subset of cell adhesion molecules, such as intercellular adhesion molecule (ICAM-1), endothelial leukocyte adhesion molecule 1 (ELAM-1), and vascular cell adhesion molecule (VCAM-1) in human umbilical vascular endothelial cells associated with an increase in the binding activity of NF-?
Regulation (intercellular) of Gene_expression (expression) of ICAM-1 in endothelial cells associated with adhesions
18) Confidence 0.07 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.22 Pain Relevance 0.10

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