INT62546

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 60
Total Number 62
Disease Relevance 59.52
Pain Relevance 16.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
endothelial cells 19
leukocytes 15
neutrophils 7
lung 5
gut 4
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1184 100.00 Very High Very High Very High
dexamethasone 11 100.00 Very High Very High Very High
cytokine 522 99.98 Very High Very High Very High
Sciatic nerve 195 99.92 Very High Very High Very High
COX2 25 99.34 Very High Very High Very High
Spinal cord 90 99.20 Very High Very High Very High
cocaine 6 99.08 Very High Very High Very High
Inflammatory marker 18 99.00 Very High Very High Very High
anesthesia 46 97.66 Very High Very High Very High
cINOD 28 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1284 100.00 Very High Very High Very High
Disease 399 100.00 Very High Very High Very High
Adhesions 396 100.00 Very High Very High Very High
Cancer 223 100.00 Very High Very High Very High
Nicotine Addiction 150 100.00 Very High Very High Very High
Necrosis 77 100.00 Very High Very High Very High
Burns 291 99.98 Very High Very High Very High
Infection 207 99.98 Very High Very High Very High
Multiple Sclerosis 193 99.96 Very High Very High Very High
Injury 663 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, rebamipide may reduce indomethacin-induced gastric mucosal injuries through its antioxidant effect, which inhibits the neutrophil activation step following up-regulation of ICAM-1 expression on endothelial cells.
Positive_regulation (regulation) of Gene_expression (expression) of ICAM-1 in endothelial cells associated with injury
1) Confidence 0.70 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16184426 Disease Relevance 0.73 Pain Relevance 0.17
This opposite modulatory role of interleukin-1 and dexamethasone on intercellular adhesion molecule-1 expression was also, for the first time, observed in vivo using mouse peritoneal macrophages: a four-fold increase in intercellular adhesion molecule-1 expression was measured after local administration of the cytokine (5 micrograms/kg) and this effect was greatly inhibited (> 70%) by co-injection with 1 microgram dexamethasone.
Positive_regulation (increase) of Gene_expression (expression) of intercellular adhesion molecule-1 in peritoneal macrophages associated with dexamethasone, adhesions and cytokine
2) Confidence 0.63 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8660354 Disease Relevance 0.44 Pain Relevance 0.30
Cd-induced ICAM-1 expression and leukocyte-EC adhesion were diminished by non-steroidal anti-inflammatory drugs such as indomethacin and NS-398, which was reversed by addition of PGE(2).
Positive_regulation (induced) of Gene_expression (expression) of ICAM-1 in leukocyte associated with inflammation, cinod and adhesions
3) Confidence 0.60 Published 2006 Journal Toxicol. Lett. Section Abstract Doc Link 16777358 Disease Relevance 0.35 Pain Relevance 0.10
COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells.
Positive_regulation (induced) of Gene_expression (expression) of ICAM-1 in endothelial cells associated with cox2
4) Confidence 0.60 Published 2006 Journal Toxicol. Lett. Section Title Doc Link 16777358 Disease Relevance 0.30 Pain Relevance 0.12
The ICAM-1 expression was markedly increased in wild-type mice following hepatic I/R (Figure 1C).
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1
5) Confidence 0.60 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.25 Pain Relevance 0.03
The upregulated expression of ICAM-1 and VCAM-1 on the microvessels of the CVOs during EAE suggests that the same molecules mediating immune cell entry across the BBB might be involved in guiding inflammatory cells into the CVOs.
Positive_regulation (upregulated) of Gene_expression (expression) of ICAM-1 in immune cell associated with multiple sclerosis and inflammation
6) Confidence 0.55 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.70 Pain Relevance 0.18
At 24 h after a 15% TBSA full-thickness thermal injury, the expressions of HO-1 and ICAM-1 in renal tissues significantly increased compared to the sham animals.
Positive_regulation (increased) of Gene_expression (expressions) of ICAM-1 associated with injury
7) Confidence 0.51 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.53 Pain Relevance 0
Our previous studies 23, 24 have showed that burn-induced overexpression of adhesion molecules (such as ICAM-1, VCAM-1) on endothelial cells and leukocytes might contribute to liver and lung tissue injury, subsequently leading the multiple organ dysfunction syndrome (MODS).
Positive_regulation (overexpression) of Gene_expression (overexpression) of ICAM-1 in leukocytes associated with multiple organ failure, burns, injury and adhesions
8) Confidence 0.51 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.20 Pain Relevance 0.20
The present results showed that at 24h post-burn, the expression levels of ICAM-1 in renal tissue were markedly upregulated.
Positive_regulation (upregulated) of Gene_expression (expression) of ICAM-1 associated with burns
9) Confidence 0.51 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.63 Pain Relevance 0.22
Furthermore, rebamipide pre-treatment notably decreased intercellular adhesion molecule-1 (ICAM-1) expression that was up-regulated in gastric tissue treated with indomethacin.
Positive_regulation (up-regulated) of Gene_expression (expression) of intercellular adhesion molecule-1 associated with adhesions
10) Confidence 0.50 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16184426 Disease Relevance 0.81 Pain Relevance 0.21
Furthermore, rebamipide pre-treatment notably decreased intercellular adhesion molecule-1 (ICAM-1) expression that was up-regulated in gastric tissue treated with indomethacin.
Positive_regulation (up-regulated) of Gene_expression (expression) of ICAM-1 associated with adhesions
11) Confidence 0.50 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16184426 Disease Relevance 0.80 Pain Relevance 0.20
The lack of a positive correlation between radicals and these markers of inflammation, as well as between clinical parameters known to be associated with increased radical production, indicates that the possible hypoperfusion that occurs during carotid endarterectomy, and which is responsible for radical production, is not enhanced enough to cause cerebral inflammation, resulting in increased ICAM-1 and MCP-1 values.
Positive_regulation (increased) of Gene_expression (values) of ICAM-1 associated with inflammation
12) Confidence 0.47 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.79 Pain Relevance 0.33
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1
13) Confidence 0.46 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.58 Pain Relevance 0.44
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1
14) Confidence 0.46 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.59 Pain Relevance 0.53
Immunohistochemistry for ICAM-1 expression and neutrophil sequestration
Positive_regulation (sequestration) of Gene_expression (expression) of ICAM-1 in neutrophil
15) Confidence 0.43 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.16 Pain Relevance 0.03
The ICAM-1 expression was markedly increased in wild-type mice following CLP and continued to be evident at 24 hours of CLP (Figure 1, WT 6 h and WT 24 h).
Positive_regulation (increased) of Gene_expression (expression) of ICAM
16) Confidence 0.41 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.18 Pain Relevance 0
RSV infection increased the expression of ICAM-1 and mucin, whereas treatment with FPS decreased their expression compared to control mice.
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1 associated with infection and respiratory syncytial virus
17) Confidence 0.41 Published 2006 Journal Virol J Section Body Doc Link PMC1488829 Disease Relevance 0.92 Pain Relevance 0.37
Mice subjected to renal IR under isoflurane anesthesia also showed a reduction in inflammation evidenced by a reduced renal influx of neutrophils and macrophages, reduced ICAM-1 expression, less upregulation of proinflammatory mRNAs (TNF-alpha, ICAM-1, KC, and IL-1beta) as well as reduced nuclear translocation of NF-kappaB 24 h after renal IR injury.
Positive_regulation (upregulation) of Gene_expression (expression) of ICAM-1 in neutrophils associated with anesthesia, inflammation, injury and isoflurane
18) Confidence 0.40 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17596528 Disease Relevance 1.32 Pain Relevance 1.04
Whereas ICAM-1 was detected on the luminal surface of the capillaries of all CVOs investigated (Figs. 7, 8 and data not shown), VCAM-1 although present on the luminal surface of microvessels in the SFO, OVLT and AP (Fig. 7 and data not shown) could not be detected on the luminal surface of the capillaries within the ME (Fig. 8).
Positive_regulation (Whereas) of Gene_expression (detected) of ICAM-1
19) Confidence 0.40 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.70 Pain Relevance 0.06
This opposite modulatory role of interleukin-1 and dexamethasone on intercellular adhesion molecule-1 expression was also, for the first time, observed in vivo using mouse peritoneal macrophages: a four-fold increase in intercellular adhesion molecule-1 expression was measured after local administration of the cytokine (5 micrograms/kg) and this effect was greatly inhibited (> 70%) by co-injection with 1 microgram dexamethasone.
Positive_regulation (role) of Gene_expression (expression) of intercellular adhesion molecule-1 in peritoneal macrophages associated with dexamethasone, adhesions and cytokine
20) Confidence 0.40 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8660354 Disease Relevance 0.44 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox