INT62547

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Context Info
Confidence 0.42
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.52
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (Anxa1) cilium (Anxa1) protein complex (Anxa1)
cytoplasm (Anxa1) extracellular space (Anxa1) signal transduction (Anxa1)
Anatomy Link Frequency
U-937 4
spinal cord 2
nerve 2
Anxa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 14 99.70 Very High Very High Very High
qutenza 1 99.02 Very High Very High Very High
Spinal cord 44 98.16 Very High Very High Very High
Neuropathic pain 55 97.04 Very High Very High Very High
Sciatic nerve 58 96.88 Very High Very High Very High
spinal dorsal horn 8 94.48 High High
Demyelination 88 88.16 High High
primary afferent fibers 1 84.60 Quite High
dexamethasone 8 83.92 Quite High
intrathecal 13 71.52 Quite High
Disease Link Frequency Relevance Heat
Adhesions 10 100.00 Very High Very High Very High
Injury 24 99.98 Very High Very High Very High
Nervous System Injury 56 99.96 Very High Very High Very High
Pain 14 99.70 Very High Very High Very High
Neuropathic Pain 73 97.04 Very High Very High Very High
Demyelinating Disease 94 88.16 High High
Hyperalgesia 15 67.04 Quite High
Ganglion Cysts 18 59.04 Quite High
Disease 1 49.76 Quite Low
INFLAMMATION 5 49.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differentiation of U-937 cells with phorbol ester (10 nM) induced a time-dependent (24 h or 48 h) increase of adhesion molecules and lipocortin 1 expression on the cell surface.
Positive_regulation (increase) of Gene_expression (expression) of lipocortin 1 in U-937 associated with adhesions
1) Confidence 0.42 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8660354 Disease Relevance 0.31 Pain Relevance 0.11
Differentiation of U-937 cells with phorbol ester (10 nM) induced a time-dependent (24 h or 48 h) increase of adhesion molecules and lipocortin 1 expression on the cell surface.
Positive_regulation (induced) of Gene_expression (expression) of lipocortin 1 in U-937 associated with adhesions
2) Confidence 0.42 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8660354 Disease Relevance 0.31 Pain Relevance 0.11
Furthermore we demonstrated that intense stimulation of spinal cord slices with pain transmitters or capsaicin, which is thought to release pain transmitters, caused a biosynthesis of LPC.
Positive_regulation (caused) of Gene_expression (biosynthesis) of LPC in spinal cord associated with pain, qutenza and spinal cord
3) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 1.09 Pain Relevance 1.15
Experiments to evaluate LPA and LPC production following nerve injury and clarify the relationship of ATX to LPA production are the next important issues to be addressed.
Positive_regulation (following) of Gene_expression (production) of LPC in nerve associated with nervous system injury
4) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2277392 Disease Relevance 1.40 Pain Relevance 0.96
Furthermore, we demonstrated that the injury-induced synthesis of LPC and subsequent conversion to LPA are both involved in the development of neuropathic pain [10,11].
Positive_regulation (induced) of Gene_expression (synthesis) of LPC associated with injury and neuropathic pain
5) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.42 Pain Relevance 0.94

General Comments

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