INT62556

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 1996
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.65
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (BDKRB1) plasma membrane (BDKRB1) signal transducer activity (BDKRB1)
Anatomy Link Frequency
HEK 2
BDKRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
B1 receptor 17 100.00 Very High Very High Very High
bradykinin 16 100.00 Very High Very High Very High
Inflammation 3 98.84 Very High Very High Very High
b2 receptor 4 98.52 Very High Very High Very High
Hyperalgesia 1 97.40 Very High Very High Very High
agonist 1 93.52 High High
antagonist 4 87.12 High High
Pain 2 78.88 Quite High
dorsal root ganglion 2 75.00 Quite High
nociceptor 1 56.28 Quite High
Disease Link Frequency Relevance Heat
Injury 3 99.28 Very High Very High Very High
INFLAMMATION 3 98.84 Very High Very High Very High
Increased Venous Pressure Under Development 1 98.28 Very High Very High Very High
Hyperalgesia 1 97.40 Very High Very High Very High
Ganglion Cysts 2 75.00 Quite High
Pain 2 57.72 Quite High
Inflammatory Pain 1 47.76 Quite Low
Sepsis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compound 11 does not importantly modify the expression of myc-B1R over 24 h in HEK 293 cells (no detectable action as "pharmacological chaperone").
Neg (not) Positive_regulation (modify) of Gene_expression (expression) of B1R in HEK associated with b1 receptor
1) Confidence 0.46 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15277582 Disease Relevance 0 Pain Relevance 0.61
The B1 receptor expression is up-regulated following tissue injury and inflammation (hyperemia, exudation, hyperalgesia, etc.).
Positive_regulation (up-regulated) of Gene_expression (expression) of B1 receptor associated with hyperalgesia, inflammation, b1 receptor, injury and increased venous pressure under development
2) Confidence 0.44 Published 1996 Journal Genomics Section Abstract Doc Link 8660997 Disease Relevance 0.39 Pain Relevance 0.42
In 1.75-day-old cultures, the marked increase in the proportion of cells with positive bradykinin binding is due to a de novo expression of the B1 receptor subtype and an up-regulation of the B2 receptor subtype.
Positive_regulation (increase) of Gene_expression (expression) of B1 receptor associated with b1 receptor, b2 receptor and bradykinin
3) Confidence 0.18 Published 1996 Journal Neuroscience Section Abstract Doc Link 8938754 Disease Relevance 0.26 Pain Relevance 0.96

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox