INT62564

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Context Info
Confidence 0.76
First Reported 1996
Last Reported 2010
Negated 0
Speculated 9
Reported most in Abstract
Documents 40
Total Number 58
Disease Relevance 15.56
Pain Relevance 17.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Syp)
Anatomy Link Frequency
synapses 5
neuronal 4
cerebral hemisphere 3
hippocampus 3
dentate gyrus 2
Syp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Root ganglion neuron 12 99.98 Very High Very High Very High
Spinal cord 7 99.92 Very High Very High Very High
amygdala 2506 99.84 Very High Very High Very High
fluoxetine 17 99.58 Very High Very High Very High
antidepressant 24 99.30 Very High Very High Very High
Thalamus 185 99.24 Very High Very High Very High
ischemia 510 99.04 Very High Very High Very High
cerebral cortex 56 98.90 Very High Very High Very High
Dopamine 4 98.88 Very High Very High Very High
Eae 11 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 12 99.82 Very High Very High Very High
Anxiety Disorder 1292 99.44 Very High Very High Very High
Cv Unclassified Under Development 444 99.04 Very High Very High Very High
Neuropathic Pain 9 98.52 Very High Very High Very High
Targeted Disruption 28 98.24 Very High Very High Very High
Injury 46 97.96 Very High Very High Very High
Shock 355 97.24 Very High Very High Very High
Nervous System Injury 8 96.84 Very High Very High Very High
Adhesions 3 95.32 Very High Very High Very High
Pain 2 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a subpopulation of isolectin B4-positive small dorsal root ganglion neurons expressed both synaptoporin and synaptophysin, and their afferent fibers were mainly distributed in the ventral part of inner lamina II.
Gene_expression (expressed) of synaptophysin in lamina associated with ganglion cysts and root ganglion neuron
1) Confidence 0.76 Published 2006 Journal Neuroscience Section Abstract Doc Link 16777346 Disease Relevance 0.53 Pain Relevance 0.55
Synaptophysin was expressed in 57% of synaptoporin-containing small dorsal root ganglion neurons and in large dorsal root ganglion neurons.
Gene_expression (expressed) of Synaptophysin in neurons associated with ganglion cysts and root ganglion neuron
2) Confidence 0.76 Published 2006 Journal Neuroscience Section Abstract Doc Link 16777346 Disease Relevance 0.39 Pain Relevance 0.34
Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury.
Gene_expression (expression) of synaptophysin in primary sensory neurons associated with nervous system injury and peripheral nerve injury
3) Confidence 0.76 Published 2006 Journal Neuroscience Section Title Doc Link 16777346 Disease Relevance 0.41 Pain Relevance 0.32
Here we investigated whether synaptogenesis as measured by the expression of synaptophysin protein correlates with symptoms of neuropathic pain in rats with a chronic constriction injury (CCI) of the sciatic nerve.
Gene_expression (expression) of synaptophysin in sciatic nerve associated with eae, injury, neuropathic pain and sciatic nerve
4) Confidence 0.76 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12429371 Disease Relevance 0.99 Pain Relevance 1.07
Altered synaptophysin expression in the rat spinal cord after chronic constriction injury of sciatic nerve.
Gene_expression (expression) of synaptophysin in spinal cord associated with eae, injury, sciatic nerve and spinal cord
5) Confidence 0.76 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12429371 Disease Relevance 0.98 Pain Relevance 1.10
Both cell types formed neuritic networks and expressed the neuron-specific markers microtubule associated protein 2, synaptophysin, neurofilament and gamma-aminobutyric acid (GABA).
Gene_expression (expressed) of synaptophysin in neuron associated with gaba
6) Confidence 0.75 Published 2003 Journal J. Neurosci. Methods Section Abstract Doc Link 12948560 Disease Relevance 0 Pain Relevance 0.30
Their distribution was measured by expressing GFP-tagged synaptophysin, a presynaptic marker specific for vesicles in boutons (Leube et al. 1987; Silver and Stryker 1999).
Gene_expression (expressing) of synaptophysin in boutons
7) Confidence 0.75 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2936807 Disease Relevance 0 Pain Relevance 0.04
In order to investigate the effects of antidepressant compounds on SVP-mRNA levels, the expressions of synaptophysin, synaptotagmin, VAMP, and synapsin-I were analysed by in situ hybridization in rats which had been treated with desipramine, fluoxetine, tranylcypromine, or saline.
Spec (analysed) Gene_expression (expressions) of synaptophysin associated with desipramine, antidepressant and fluoxetine
8) Confidence 0.70 Published 2004 Journal Pharmacogenomics J. Section Abstract Doc Link 14708000 Disease Relevance 0.09 Pain Relevance 0.65
The results demonstrate that chronic treatment with fluoxetine and tranylcypromine leads to an increased expression of synaptophysin, but decreased expression of synaptotagmin and VAMP in the hippocampus and cerebral cortex.
Gene_expression (expression) of synaptophysin in cerebral cortex associated with hippocampus, cerebral cortex and fluoxetine
9) Confidence 0.70 Published 2004 Journal Pharmacogenomics J. Section Abstract Doc Link 14708000 Disease Relevance 0.08 Pain Relevance 0.70
Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon.
Gene_expression (expression) of synaptophysin in telencephalon associated with antidepressant
10) Confidence 0.62 Published 2007 Journal Eur Neuropsychopharmacol Section Title Doc Link 17307340 Disease Relevance 0.15 Pain Relevance 0.45
In order to know whether chronic fluoxetine treatment induces differential neuronal structural plasticity in rats, we have analyzed the expression of synaptophysin, a protein considered a marker of synaptic density, and the expression of the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), a molecule involved in neurite and synaptic remodeling.
Spec (analyzed) Gene_expression (expression) of synaptophysin in neuronal associated with adhesions and fluoxetine
11) Confidence 0.62 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17307340 Disease Relevance 0.19 Pain Relevance 0.48
Chronic fluoxetine treatment increases synaptophysin and PSA-NCAM expression in the medial prefrontal cortex and decreases them in the amygdala.
Gene_expression (expression) of synaptophysin in medial associated with amygdala and fluoxetine
12) Confidence 0.62 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17307340 Disease Relevance 0.18 Pain Relevance 0.47
We found that this general anesthesia causes permanent neuronal deletion in the most vulnerable brain regions-the cerebral cortex and the thalamus-while transiently modulating protein levels of synaptophysin, synaptobrevin, amphiphysin, SNAP-25, and CaM kinase II.
Gene_expression (levels) of synaptophysin in cerebral cortex associated with anesthesia, thalamus and cerebral cortex
13) Confidence 0.58 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077565 Disease Relevance 0.15 Pain Relevance 0.53
In support of this hypothesis, we have shown that intra-MGm/PIN infusion of a MEK inhibitor blocks synaptic plasticity in the LA [43] and, more recently, that intra-MGm/PIN infusion of an antisense oligodeoxynucleotide to EGR-1 impairs the training-induced expression of synapsin and synaptophysin at LA synapses [32].
Gene_expression (expression) of synaptophysin in synapses associated with amygdala
14) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.35 Pain Relevance 0.47
Western blotting on tissue taken from the LA was performed to assay training-induced expression of GluR1, synapsin, and synaptophysin in the LA at each of the different time points.
Gene_expression (expression) of synaptophysin associated with amygdala
15) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.71 Pain Relevance 0.18
Finally, a recent study has shown that fear conditioning leads to an increase in the expression of the presynaptically- localized protein synaptophysin at LA synapses [31].
Gene_expression (expression) of synaptophysin in synapses associated with anxiety disorder and amygdala
16) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.59 Pain Relevance 0.55
For example, glutamate-induced LTP in hippocampal cell cultures has been shown to promote an increase in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synapsin I and synaptophysin, as well as a corresponding increase in co-localization of GluR1 and synaptophysin/synapsin I-labeled puncta [24].
Gene_expression (expression) of synaptophysin associated with glutamate and long-term potentiation
17) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0 Pain Relevance 0.18
Post hoc analysis using Duncan's t-tests showed that the Paired group exhibited significantly higher expression of GluR1, synapsin, and synaptophysin relative to the Naïve (p<0.001), Tone Alone (p<0.001), or Immediate Shock groups (p<0.001).
Gene_expression (expression) of synaptophysin associated with shock
18) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.79 Pain Relevance 0.17
In the present study, we show that auditory Pavlovian fear conditioning is associated with significant and persistent increases in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synapsin and synaptophysin in the LA.
Gene_expression (expression) of synaptophysin associated with anxiety disorder and amygdala
19) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.37 Pain Relevance 0.33
Finally, we show that intra-LA infusions of the ROCK inhibitor Y-27632 or the CaMKII inhibitor KN-93 impair training-induced expression of GluR1, synapsin, and synaptophysin in the LA.
Gene_expression (expression) of synaptophysin associated with amygdala
20) Confidence 0.44 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2888610 Disease Relevance 0.23 Pain Relevance 0.49

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