INT62568

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Context Info
Confidence 0.68
First Reported 1996
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 8.61
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp) extracellular region (Crp)
Anatomy Link Frequency
upper 2
Crp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory marker 2 100.00 Very High Very High Very High
Angina 23 99.96 Very High Very High Very High
methotrexate 12 99.32 Very High Very High Very High
Inflammation 7 93.00 High High
cINOD 2 92.96 High High
cytokine 2 89.04 High High
palliative 2 88.56 High High
cva 35 86.88 High High
Arthritis 2 76.28 Quite High
analgesia 1 72.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 9 100.00 Very High Very High Very High
Cytomegalovirus Infection 2 100.00 Very High Very High Very High
Ulcers 2 100.00 Very High Very High Very High
Chlamydia Infection 2 100.00 Very High Very High Very High
Cv General 3 Under Development 58 99.96 Very High Very High Very High
Cancer 4 99.70 Very High Very High Very High
Apnoea 83 98.96 Very High Very High Very High
Jaundice 1 98.96 Very High Very High Very High
Pulmonary Disease 85 98.64 Very High Very High Very High
Acute Coronary Syndrome 3 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The grade of instability of coronary lesions as predicted by the increases in C-reactive protein induced by PTCA and/or stenting was closely correlated with Braunwald's classification of unstable angina.
Positive_regulation (increases) of Positive_regulation (induced) of C-reactive protein associated with angina
1) Confidence 0.68 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11152846 Disease Relevance 0.36 Pain Relevance 0.36
The grade of instability of coronary lesions as predicted by the increases in C-reactive protein induced by PTCA and/or stenting was closely correlated with Braunwald's classification of unstable angina.
Positive_regulation (induced) of Positive_regulation (increases) of C-reactive protein associated with angina
2) Confidence 0.46 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11152846 Disease Relevance 0.36 Pain Relevance 0.36
While the imputation may have diluted the effect of the prioritisation strategies including highly sensitive C reactive protein, the relative risks estimates for C reactive protein are likely to be inflated because of publication bias and inadequate adjustment for the routinely recorded factors known to relate to both highly sensitive C reactive protein and outcome (including smoking, diabetes, obesity, and lipid concentrations).17 Even when using the upper 95% confidence limit for the C reactive protein effect, a prioritisation strategy with a risk score using information from highly sensitive C reactive protein and estimated glomerular filtration rate had an incremental cost effectiveness ratio exceeding £40?
Spec (likely) Positive_regulation (likely) of Positive_regulation (estimates) of reactive protein in upper associated with nicotine addiction, diabetes mellitus and obesity
3) Confidence 0.34 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2808469 Disease Relevance 0.28 Pain Relevance 0
Baseline characteristics were similar to the first cohort (Table 1) except for a slightly higher prevalence of elevated C-reactive protein (>3 mg/L) in the validation cohort.
Neg (except) Positive_regulation (prevalence) of Neg (except) Positive_regulation (elevated) of C-reactive protein
4) Confidence 0.31 Published 2003 Journal BMC Cardiovasc Disord Section Body Doc Link PMC194644 Disease Relevance 0.17 Pain Relevance 0.04
It is concluded that in patients with unstable angina, elevated levels of serum fibrinogen and C-reactive protein at admission indicate an adverse in-hospital outcome and a more complex coronary morphology.
Positive_regulation (levels) of Positive_regulation (elevated) of C-reactive protein associated with angina
5) Confidence 0.25 Published 2000 Journal Indian Heart J Section Abstract Doc Link 10820931 Disease Relevance 0.62 Pain Relevance 0.46
We evaluated the serum levels of IgG antibodies to Helicobacter pylori, Chlamydia pneumoniae and cytomegalovirus and the level of the inflammatory markers C-reactive protein and fibrinogen in 57 patients with acute coronary syndrome, 65 with unstable angina, 60 with stable angina and 44 healthy controls, and whether these markers were associated with cardiac instability 6 months after admission. acute There was a significant increased risk of late coronary events (cardiac death or readmission with coronary events) associated with seropositivity to C. pneumoniae (adjusted odds ratio 2.12; 95% confidence interval: 1.16-4.08).
Spec (whether) Positive_regulation (evaluated) of Spec (whether) Positive_regulation (level) of C-reactive protein associated with acute coronary syndrome, angina, inflammatory marker, ulcers, cytomegalovirus infection, chlamydia infection and death
6) Confidence 0.23 Published 2008 Journal East. Mediterr. Health J. Section Abstract Doc Link 19161100 Disease Relevance 0.93 Pain Relevance 0.28
We evaluated the serum levels of IgG antibodies to Helicobacter pylori, Chlamydia pneumoniae and cytomegalovirus and the level of the inflammatory markers C-reactive protein and fibrinogen in 57 patients with acute coronary syndrome, 65 with unstable angina, 60 with stable angina and 44 healthy controls, and whether these markers were associated with cardiac instability 6 months after admission. acute There was a significant increased risk of late coronary events (cardiac death or readmission with coronary events) associated with seropositivity to C. pneumoniae (adjusted odds ratio 2.12; 95% confidence interval: 1.16-4.08).
Spec (whether) Positive_regulation (level) of Spec (whether) Positive_regulation (markers) of C-reactive protein associated with acute coronary syndrome, angina, inflammatory marker, ulcers, cytomegalovirus infection, chlamydia infection and death
7) Confidence 0.23 Published 2008 Journal East. Mediterr. Health J. Section Abstract Doc Link 19161100 Disease Relevance 0.93 Pain Relevance 0.28
Elevated levels of ferritin and C-reactive protein in the sera rapidly normalised.
Positive_regulation (levels) of Positive_regulation (Elevated) of C-reactive protein
8) Confidence 0.12 Published 1998 Journal Clin. Rheumatol. Section Abstract Doc Link 9694066 Disease Relevance 0.74 Pain Relevance 0.40
Elevated levels of ferritin and C-reactive protein in the sera rapidly normalised.
Positive_regulation (Elevated) of Positive_regulation (levels) of C-reactive protein
9) Confidence 0.12 Published 1998 Journal Clin. Rheumatol. Section Abstract Doc Link 9694066 Disease Relevance 0.74 Pain Relevance 0.40
Comparison of the results of the two cholecystectomy techniques showed that laparoscopic cholecystectomy induced a significantly less intensive acute-phase response (area under the curve) of interleukin 6 (17 +/- 17 versus 47 +/- 26 pg/ml x hr x 10(2); p < 0.003), C-reactive protein (16 +/- 12 versus 35 +/-16 mg/dl x hr x 10; p < 0.004), and prealbumin (16 +/- 2.7 versus 13.8 +/- 2.3 mg/dl x hr x 10(2); p < 0.05).
Positive_regulation (induced) of Positive_regulation (response) of C-reactive protein
10) Confidence 0.05 Published 1996 Journal World J Surg Section Abstract Doc Link 8661626 Disease Relevance 0.29 Pain Relevance 0.07
Multivariate analysis indicated that ten factors had a significant independent effect on survival: chemotherapy, surgery, tumor localization, elevated C-reactive protein, elevated CeA, CA 19-9 (>30 x nl), jaundice at diagnosis, weight loss >10%, distant metastases, and Karnofsky performance status.
Positive_regulation (elevated) of Positive_regulation (elevated) of C-reactive protein associated with weight loss, cancer, jaundice and metastasis
11) Confidence 0.05 Published 2009 Journal J Chemother Section Abstract Doc Link 20071292 Disease Relevance 0.92 Pain Relevance 0.17
Patients with severe COPD and unknown OSA status are 2.18 and 2.74 times more likely to have elevated and highly elevated, respectively, circulating C-reactive protein levels than control subjects (Sin et al 2003).
Positive_regulation (elevated) of Spec (likely) Positive_regulation (elevated) of C-reactive protein associated with apnoea and pulmonary disease
12) Confidence 0.02 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629968 Disease Relevance 2.25 Pain Relevance 0.14

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