INT62576

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 34
Total Number 36
Disease Relevance 16.97
Pain Relevance 10.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
brain 2
dorsal 1
nucleus 1
amygdala 1
central nervous system 1
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 43 99.98 Very High Very High Very High
antidepressant 659 99.62 Very High Very High Very High
withdrawal 16 99.24 Very High Very High Very High
Hippocampus 401 99.16 Very High Very High Very High
Morphine 32 98.80 Very High Very High Very High
depression 260 98.64 Very High Very High Very High
opiate 3 97.68 Very High Very High Very High
Kinase C 19 97.44 Very High Very High Very High
addiction 98 97.40 Very High Very High Very High
sSRI 68 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1195 99.84 Very High Very High Very High
Targeted Disruption 571 99.52 Very High Very High Very High
Epilepsy 6 99.24 Very High Very High Very High
Depression 331 98.64 Very High Very High Very High
Weight Loss 1 98.56 Very High Very High Very High
Weight Gain 17 97.76 Very High Very High Very High
Opiate Addiction 2 97.68 Very High Very High Very High
Morphine Dependence 3 95.72 Very High Very High Very High
Hyperlipidemia 6 95.36 Very High Very High Very High
Disease 292 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CREB is a transcription factor regulated through phosphorylation on Ser133, which is known to play a key role in the mechanism of morphine dependence.
Transcription (transcription) of CREB associated with addiction and morphine
1) Confidence 0.69 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19289113 Disease Relevance 0.27 Pain Relevance 1.09
The effects of signalling pathways involving adenylate cyclase and cAMP, Ca2+ and different kinases on CREB/CREB-regulated gene transcription are well established[30].
Transcription (transcription) of CREB
2) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.72 Pain Relevance 0.19
The effects of signalling pathways involving adenylate cyclase and cAMP, Ca2+ and different kinases on CREB/CREB-regulated gene transcription are well established[30].
Transcription (transcription) of CREB
3) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.72 Pain Relevance 0.19
In the central nervous system CREB action was first described for the adrenergic system where generation of cAMP by ?
Transcription (described) of CREB in central nervous system associated with central nervous system
4) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.22 Pain Relevance 0.35
The transcription factor cAMP-responsive element binding protein (CREB) and its binding site (CRE) have been suggested to play a major role in both the development of depression and antidepressive therapy.


Transcription (transcription) of cAMP-responsive element binding protein associated with depression
5) Confidence 0.68 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1855984 Disease Relevance 0.83 Pain Relevance 0.22
The transcription factor cAMP-responsive element binding protein (CREB) and its binding site (CRE) have been suggested to play a major role in both the development of depression and antidepressive therapy.


Transcription (transcription) of CREB associated with depression
6) Confidence 0.68 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1855984 Disease Relevance 0.83 Pain Relevance 0.22
Furthermore, we determined effects of chronic social stress and of the antidepressant imipramine on CRE/CREB-directed gene transcription in vivo.
Transcription (transcription) of CREB associated with stress and antidepressant
7) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 1.06 Pain Relevance 0.16
A good reason for differential CREB or pCREB expression is that different central nuclei and cell populations offer various gene targets for these transcription factors, each likely exhibiting their own sensitivites to changes in the CREB transcription factor to induce gene transcription.
Transcription (transcription) of CREB
8) Confidence 0.67 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0 Pain Relevance 0.03
A key mechanism for regulating gene expression is through nuclear induction of the transcription factor CREB, implicated also in various affective states, learning and memory.
Transcription (transcription) of CREB
9) Confidence 0.67 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.06 Pain Relevance 0.15
These findings suggest that morphine reward can influence the expression of RACK1 in mouse hippocampus and prefrontal cortex through regulating CREB transcription.
Transcription (transcription) of CREB in cortex associated with hippocampus and morphine
10) Confidence 0.64 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.12 Pain Relevance 0.81
Among the proteins that regulate gene transcription the transcription factor CREB (cAMP responsive element binding protein) is one of the most widely expressed.
Transcription (transcription) of factor CREB
11) Confidence 0.59 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.33 Pain Relevance 0.34
Mechanistically, DREAM functions as a negative regulator of the key memory factor CREB in a Ca(2+)-dependent manner, and loss of DREAM facilitates CREB-dependent transcription during learning.
Transcription (transcription) of CREB-dependent
12) Confidence 0.56 Published 2009 Journal Curr. Biol. Section Abstract Doc Link 19110430 Disease Relevance 0.44 Pain Relevance 0.17
Thus, CREB-dependent gene transcription is a factor in the onset of behavioral manifestations of opiate dependence.
Transcription (transcription) of CREB-dependent gene associated with addiction and opiate
13) Confidence 0.53 Published 1996 Journal Science Section Abstract Doc Link 8662559 Disease Relevance 0.10 Pain Relevance 1.02
In response to glucagon, protein kinase A phosphorylates transcription factor CREB at Ser133 and increases its transcriptional activity (23), which activates the expression of PGC-1?
Transcription (transcription) of CREB
14) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.09 Pain Relevance 0.03
Using a transgenic LacZ reporter mouse to measure transcriptional activity of CREB, Thome and colleagues found a more pronounced activating effect by the SSRI fluoxetine compared to the pro-noradrenergic antidepressant desipramine[17].
Transcription (activity) of CREB associated with targeted disruption, desipramine, antidepressant, ssri and fluoxetine
15) Confidence 0.53 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.36 Pain Relevance 0.63
Thus, the chronic treatment with imipramine completely abolished the stimulating effect of chronic social stress on CRE/CREB-directed transcription and resulted in levels similar to control.


Transcription (transcription) of CREB associated with stress
16) Confidence 0.53 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.58 Pain Relevance 0.11
Furthermore, there is currently no information related to the actions of stress on CRE/CREB-directed gene transcription in vivo.
Transcription (transcription) of CREB associated with stress
17) Confidence 0.53 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.48 Pain Relevance 0.14
Furthermore, we examined the action of the antidepressant imipramine on CRE/CREB-directed transcription.
Transcription (transcription) of CREB associated with antidepressant
18) Confidence 0.53 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.77 Pain Relevance 0.34
In the present study the sensory contact model was applied to SomCRE-Luc mice in order to investigate the influence of chronic psychosocial stress on the CRE/CREB-directed transcription.
Transcription (transcription) of CREB associated with stress
19) Confidence 0.53 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.87 Pain Relevance 0.11
In this study we determined the effect of chronic psychosocial stress and of imipramine treatment on the transcriptional activity of CREB in vivo.
Transcription (activity) of CREB associated with stress
20) Confidence 0.53 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.71 Pain Relevance 0.03

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