INT62579

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.95
Pain Relevance 5.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 4
1A2 2
embryonic stem cells 2
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 73 100.00 Very High Very High Very High
halothane 1 78.00 Quite High
Analgesic 2 76.28 Quite High
antagonist 2 75.00 Quite High
cva 1 74.08 Quite High
Disease Link Frequency Relevance Heat
Overdose 2 98.74 Very High Very High Very High
Targeted Disruption 11 98.04 Very High Very High Very High
Cancer 1 97.24 Very High Very High Very High
Congenital Anomalies 2 86.16 High High
Hepatotoxicity 9 85.68 High High
Injury 8 84.64 Quite High
Necrosis 6 81.08 Quite High
Toxicity 3 75.00 Quite High
Hemorrhage 1 74.08 Quite High
Liver Cancer 1 66.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show that the hepatoprotective effects of BA against AP overdose may be due to its ability to block the bioactivation of AP by inhibiting CYP2E1 expression.
Negative_regulation (inhibiting) of Gene_expression (expression) of CYP2E1 associated with paracetamol and overdose
1) Confidence 0.59 Published 2003 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 14686800 Disease Relevance 0.31 Pain Relevance 0.96
Oral treatment of mice with BA resulted in a significant decrease in AP-induced CYP2E1 activity together with its inhibition of AP-induced CYP2EI expression.
Negative_regulation (inhibition) of Gene_expression (expression) of CYP2EI associated with paracetamol
2) Confidence 0.57 Published 2003 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 14686800 Disease Relevance 0.23 Pain Relevance 1.01
The cyp2e1 gene was isolated, and a mouse line that lacks expression of CYP2E1 was generated by homologous recombination in embryonic stem cells.
Negative_regulation (lacks) of Gene_expression (expression) of CYP2E1 in embryonic stem cells
3) Confidence 0.43 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8662637 Disease Relevance 0.33 Pain Relevance 0.21
Western blot and high-performance liquid chromatography/mass spectrometry analyses revealed human CYP2E1 protein expression and enzymatic activity in the liver of CYP2E1-humanized mice.
Negative_regulation (revealed) of Gene_expression (expression) of CYP2E1 in liver
4) Confidence 0.43 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15576447 Disease Relevance 0.53 Pain Relevance 0.42
To test the combined roles of CYP1A2 and CYP2E1 in an intact animal model, a double-null mouse line lacking functional expression of CYP1A2 and CYP2E1 was produced by cross-breeding Cyp1a2-/- mice with Cyp2e1-/- mice.
Negative_regulation (lacking) of Gene_expression (expression) of CYP2E1
5) Confidence 0.42 Published 1998 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9772215 Disease Relevance 0.48 Pain Relevance 0.40
CYP2E1 and 1A2 expressions were decreased significantly by CCl(4).
Negative_regulation (decreased) of Gene_expression (expressions) of CYP2E1 in 1A2
6) Confidence 0.40 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 16445600 Disease Relevance 0.06 Pain Relevance 1.17
By contrast, the intranuclear amount of p65 of NF-kappaB, which can suppress the gene expression of CYP1A2, CYP2E1, and CYP3A11, was higher in untreated IL-1ra KO than WT mice.
Negative_regulation (suppress) of Gene_expression (expression) of CYP2E1
7) Confidence 0.38 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.43 Pain Relevance 1.21
Furthermore, the expression of two cytochrome P450 enzymes, CYP1A2 and CYP2E1, was almost completely abolished in livers from hepatocyte-specific beta-catenin knockout mice.
Negative_regulation (abolished) of Gene_expression (expression) of CYP2E1 in livers associated with targeted disruption
8) Confidence 0.36 Published 2006 Journal Hepatology Section Abstract Doc Link 16557553 Disease Relevance 0.58 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox