INT62580

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 31
Total Number 31
Disease Relevance 15.40
Pain Relevance 11.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 9
hepatocyte 1
Mouse 1
1A2 1
embryonic stem cells 1
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 138 99.82 Very High Very High Very High
Inflammation 71 99.68 Very High Very High Very High
halothane 6 98.68 Very High Very High Very High
alcohol 31 97.84 Very High Very High Very High
chemokine 5 97.36 Very High Very High Very High
cytokine 12 96.72 Very High Very High Very High
isoflurane 5 96.16 Very High Very High Very High
cva 3 95.36 Very High Very High Very High
Analgesic 9 86.16 High High
Bile 8 84.64 Quite High
Disease Link Frequency Relevance Heat
Porphyria 3 100.00 Very High Very High Very High
Targeted Disruption 57 99.88 Very High Very High Very High
INFLAMMATION 69 99.68 Very High Very High Very High
Fatty Liver 93 98.98 Very High Very High Very High
Overdose 3 98.52 Very High Very High Very High
Liver Disease 35 98.40 Very High Very High Very High
Toxicity 54 98.38 Very High Very High Very High
Injury 77 97.84 Very High Very High Very High
Nicotine Addiction 138 97.54 Very High Very High Very High
Obesity 31 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cyp2e1 gene was isolated, and a mouse line that lacks expression of CYP2E1 was generated by homologous recombination in embryonic stem cells.
Gene_expression (expression) of CYP2E1 in embryonic stem cells
1) Confidence 0.78 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8662637 Disease Relevance 0.33 Pain Relevance 0.21
These results show that the hepatoprotective effects of BA against AP overdose may be due to its ability to block the bioactivation of AP by inhibiting CYP2E1 expression.
Gene_expression (expression) of CYP2E1 associated with paracetamol and overdose
2) Confidence 0.78 Published 2003 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 14686800 Disease Relevance 0.31 Pain Relevance 0.95
Western blot and high-performance liquid chromatography/mass spectrometry analyses revealed human CYP2E1 protein expression and enzymatic activity in the liver of CYP2E1-humanized mice.
Gene_expression (expression) of CYP2E1 in liver
3) Confidence 0.78 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15576447 Disease Relevance 0.52 Pain Relevance 0.42
A transgenic mouse line expressing the human CYP2E1 gene was established.
Gene_expression (expressing) of CYP2E1 gene associated with targeted disruption
4) Confidence 0.78 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15576447 Disease Relevance 0.39 Pain Relevance 0.41
To test the combined roles of CYP1A2 and CYP2E1 in an intact animal model, a double-null mouse line lacking functional expression of CYP1A2 and CYP2E1 was produced by cross-breeding Cyp1a2-/- mice with Cyp2e1-/- mice.
Gene_expression (expression) of CYP2E1
5) Confidence 0.77 Published 1998 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9772215 Disease Relevance 0.48 Pain Relevance 0.40
Increases in Cyp2e1 and Cyp2b expression were also evident in male kidney.
Gene_expression (expression) of Cyp2e1 in kidney
6) Confidence 0.76 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17610925 Disease Relevance 0.66 Pain Relevance 0.07
Oral treatment of mice with BA resulted in a significant decrease in AP-induced CYP2E1 activity together with its inhibition of AP-induced CYP2EI expression.
Gene_expression (expression) of CYP2EI associated with paracetamol
7) Confidence 0.75 Published 2003 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 14686800 Disease Relevance 0.22 Pain Relevance 1.00
The liver expresses many cytochrome P450 isoforms, including ethanol-induced CYP2E1.
Gene_expression (expresses) of CYP2E1 in liver
8) Confidence 0.75 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11812920 Disease Relevance 1.22 Pain Relevance 0.23
CYP2E1 and 1A2 expressions were decreased significantly by CCl(4).
Gene_expression (expressions) of CYP2E1 in 1A2
9) Confidence 0.73 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 16445600 Disease Relevance 0.06 Pain Relevance 1.17
Data presented in this review demonstrated that the most comprehensive studies using Cyp2e1-/- mice, encompassing the entire paradigm of metabolism to toxicity, genotoxicity, and carcinogenicity were possible when a substrate was primarily metabolized via CYP2E1 (e.g. urethane and acrylamide).
Gene_expression (metabolized) of CYP2E1 associated with toxicity
10) Confidence 0.67 Published 2007 Journal Curr. Drug Metab. Section Abstract Doc Link 17979661 Disease Relevance 0.34 Pain Relevance 0.06
HNF-1alpha and clock genes may contribute to produce the 24-h rhythm of CYP2E1 mRNA levels.
Gene_expression (produce) of CYP2E1
11) Confidence 0.67 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881208 Disease Relevance 0.23 Pain Relevance 0.49
Creating "humanized" mice by introducing the human CYP2E1 gene into Cyp2e1-null mice can circumvent this disadvantage.
Gene_expression (introducing) of CYP2E1 gene
12) Confidence 0.67 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15576447 Disease Relevance 0.37 Pain Relevance 0.41
Furthermore, the expression of two cytochrome P450 enzymes, CYP1A2 and CYP2E1, was almost completely abolished in livers from hepatocyte-specific beta-catenin knockout mice.
Gene_expression (expression) of CYP2E1 in livers associated with targeted disruption
13) Confidence 0.65 Published 2006 Journal Hepatology Section Abstract Doc Link 16557553 Disease Relevance 0.58 Pain Relevance 0.09
was activated after TRI exposure in wild-type but not CYP2E1-null mice, which they attributed to a lack of CYP2E1-mediated production of TCA.
Gene_expression (production) of CYP2E1
14) Confidence 0.61 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.24 Pain Relevance 0.03
Rats fed on this diet for 3 weeks developed several of the key features of NAFLD, including steatosis, inflammation, and increased CYP2E1 protein levels, whereas hepatocyte ballooning and Mallory bodies were not observed.
Gene_expression (levels) of CYP2E1 protein in hepatocyte associated with fatty liver and inflammation
15) Confidence 0.60 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 1.21 Pain Relevance 0.05
Administration of Isoflurane (a single dose of 2 ml/kg, i.p) to wild-type (+/+), heterozygous (+/Fechm1Pas) and homozygous (Fechm1Pas/Fechm1Pas) mice, was evaluated by measuring the activity of delta-aminolevulinic acid synthetase (ALA-S) and Porphobilinogen-deaminase (PBG-D) in different tissues, as well as Heme oxygenase (HO), cytochrome P-450, CYP2E1 and glutathione levels in liver.
Gene_expression (synthetase) of CYP2E1 in liver associated with porphyria and isoflurane
16) Confidence 0.59 Published 2009 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 19268000 Disease Relevance 0.79 Pain Relevance 0.27
Mouse lines lacking the P450s CYP1A1, CYP1A2, CYP1B1 and CYP2E1, microsomal epoxide hydrolase (mEH), NADPH:quinone oxidoreductase and the glutathione S-transferase P1 have no deleterious phenotypes, indicating that these enzymes are not required for mammalian development and physiological homeostasis.
Neg (lacking) Gene_expression (lacking) of CYP2E1 in Mouse
17) Confidence 0.58 Published 2001 Journal Toxicol. Lett. Section Abstract Doc Link 11323178 Disease Relevance 0.30 Pain Relevance 0.07
Results showed that the catalytic activity and polypeptide levels of CYP1A2, CYP2E1, and CYP3A were unchanged in the treatment groups compared to vehicle and untreated controls.
Gene_expression (levels) of CYP2E1
18) Confidence 0.58 Published 2001 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11437634 Disease Relevance 0.29 Pain Relevance 0.76
Increased CYP2E1 protein levels are observed in animal models of fatty liver diseases and in morbid obese men with NAFLD and patients with NASH [101, 102].
Gene_expression (levels) of CYP2E1 in liver associated with fatty liver, liver disease, nash(non-alcoholic steatohepatitis) and obesity
19) Confidence 0.56 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.03 Pain Relevance 0.08
Expression of CYP1A1 (p < 0.01), CYP1B1 (p < 0.001), and CYP2S1 (p < 0.001) was higher in BAL cells from smokers compared with those of nonsmokers (Figure 1), whereas expression of CYP2B6/7 (p < 0.01) and CYP3A5 (p < 0.001) was lower; expression of CYP2A6/7, CYP2E1, CYP2C9, CYP2J2, and FMO5 was not altered.
Gene_expression (expression) of CYP2E1 associated with nicotine addiction
20) Confidence 0.56 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.76 Pain Relevance 0

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