INT62595

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1D) signal transducer activity (HTR1D)
HTR1D (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 11 100.00 Very High Very High Very High
adenocard 2 100.00 Very High Very High Very High
agonist 9 99.24 Very High Very High Very High
Sumatriptan 7 97.90 Very High Very High Very High
antagonist 8 81.92 Quite High
Central nervous system 1 67.28 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sumatriptan, GR127935 and metergoline (each 0.01-1 microM) behaved as agonists, producing a concentration-dependent inhibition of forskolin-stimulated adenosine 3',5'-cyclic monophosphate (cAMP) production at both 5-HT1D alpha and 5-HT1D beta receptor subtypes (mean pIC50 values of 8.4 and 8.3 for sumatriptan, 7.9 and 8.0 for GR127935, and 7.9 and 8.3 for metergoline, respectively).
Negative_regulation (inhibition) of Gene_expression (production) of 5-HT1D associated with sumatriptan, adenocard and agonist
1) Confidence 0.41 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8666030 Disease Relevance 0 Pain Relevance 0.60
Sumatriptan, GR127935 and metergoline (each 0.01-1 microM) behaved as agonists, producing a concentration-dependent inhibition of forskolin-stimulated adenosine 3',5'-cyclic monophosphate (cAMP) production at both 5-HT1D alpha and 5-HT1D beta receptor subtypes (mean pIC50 values of 8.4 and 8.3 for sumatriptan, 7.9 and 8.0 for GR127935, and 7.9 and 8.3 for metergoline, respectively).
Negative_regulation (inhibition) of Gene_expression (production) of 5-HT1D associated with sumatriptan, adenocard and agonist
2) Confidence 0.41 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8666030 Disease Relevance 0 Pain Relevance 0.60
The expression of the mRNA 5-HT1D serotonin receptor was also detected in blastocysts cultured in vitro.
Negative_regulation (detected) of Gene_expression (expression) of 5-HT1D associated with serotonin
3) Confidence 0.41 Published 2003 Journal Physiol Res Section Abstract Doc Link 12678665 Disease Relevance 0 Pain Relevance 0.62

General Comments

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