INT626

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1976
Last Reported 2011
Negated 4
Speculated 2
Reported most in Abstract
Documents 289
Total Number 292
Disease Relevance 125.39
Pain Relevance 221.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
nerve 22
sensory nerves 13
sensory neurons 11
trigeminal ganglion 10
head 9
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 4265 100.00 Very High Very High Very High
qutenza 1770 100.00 Very High Very High Very High
Pain 1077 100.00 Very High Very High Very High
Neuropeptide 632 100.00 Very High Very High Very High
substance P 626 100.00 Very High Very High Very High
Triptan 566 100.00 Very High Very High Very High
Inflammation 467 100.00 Very High Very High Very High
Neurotransmitter 150 100.00 Very High Very High Very High
Analgesic 146 100.00 Very High Very High Very High
cytokine 108 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 1097 100.00 Very High Very High Very High
INFLAMMATION 428 100.00 Very High Very High Very High
Carcinoid 18 99.98 Very High Very High Very High
Ganglion Cysts 309 99.96 Very High Very High Very High
Cluster Headache 76 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 320 99.92 Very High Very High Very High
Headache 1413 99.88 Very High Very High Very High
Neurogenic Inflammation 105 99.84 Very High Very High Very High
Hypercalcemia 21 99.84 Very High Very High Very High
Meningitis 3 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene-related peptide (CGRP) and substance P in the stomach.
Localization (release) of CGRP in nerves associated with qutenza, substance p and calcitonin gene-related peptide
1) Confidence 0.81 Published 2004 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 15099451 Disease Relevance 0.09 Pain Relevance 0.63
Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene-related peptide (CGRP) and substance P in the stomach.
Localization (release) of calcitonin gene-related peptide in nerves associated with qutenza, substance p and calcitonin gene-related peptide
2) Confidence 0.81 Published 2004 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 15099451 Disease Relevance 0.09 Pain Relevance 0.63
Light microscopic localization of calcitonin gene-related peptide in the normal feline trigeminal system and following retrogasserian rhizotomy.
Localization (localization) of calcitonin associated with calcitonin gene-related peptide
3) Confidence 0.81 Published 1996 Journal J. Comp. Neurol. Section Title Doc Link 8742300 Disease Relevance 0.25 Pain Relevance 0.48
There is a clear association between head pain and the release of calcitonin gene-related peptide (CGRP).
Localization (release) of CGRP in head associated with headache and calcitonin gene-related peptide
4) Confidence 0.81 Published 2007 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 17845144 Disease Relevance 0.77 Pain Relevance 1.22
By contrast no release of calcitonin gene-related peptide (CGRP)-LI was produced upon the first or second application of capsaicin.
Localization (release) of CGRP associated with qutenza and calcitonin gene-related peptide
5) Confidence 0.81 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2786168 Disease Relevance 0 Pain Relevance 0.50
By contrast no release of calcitonin gene-related peptide (CGRP)-LI was produced upon the first or second application of capsaicin.
Localization (release) of calcitonin gene-related peptide associated with qutenza and calcitonin gene-related peptide
6) Confidence 0.81 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2786168 Disease Relevance 0 Pain Relevance 0.50
Extrinsic denervation decreased basal CGRP release and abolished CGRP release and peristaltic responses normally elicited by muscle stretch but not CGRP release or peristaltic responses elicited by mucosal stimulation.
Localization (release) of CGRP in muscle associated with calcitonin gene-related peptide
7) Confidence 0.81 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7912896 Disease Relevance 0.05 Pain Relevance 0.53
Calcitonin gene-related peptide (CGRP) and substance P co-exist in capsaicin-sensitive primary sensory neurons and are released from the myocardium after activation of sensory nerve fibres as well as by ischemia in animals.
Localization (released) of Calcitonin gene-related peptide in myocardium associated with qutenza, ischemia, substance p and calcitonin gene-related peptide
8) Confidence 0.81 Published 1999 Journal Scand. Cardiovasc. J. Section Abstract Doc Link 10540919 Disease Relevance 0.58 Pain Relevance 0.63
Both muscle stretch and mucosal stroking applied to the central compartment elicited CGRP release into the central, but not peripheral, compartments.
Localization (release) of CGRP in muscle associated with calcitonin gene-related peptide
9) Confidence 0.81 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7912896 Disease Relevance 0.08 Pain Relevance 0.45
Extrinsic denervation decreased basal CGRP release and abolished CGRP release and peristaltic responses normally elicited by muscle stretch but not CGRP release or peristaltic responses elicited by mucosal stimulation.
Localization (release) of CGRP in muscle associated with calcitonin gene-related peptide
10) Confidence 0.81 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7912896 Disease Relevance 0 Pain Relevance 0.50
Calcitonin gene-related peptide (CGRP) and substance P co-exist in capsaicin-sensitive primary sensory neurons and are released from the myocardium after activation of sensory nerve fibres as well as by ischemia in animals.
Localization (released) of CGRP in myocardium associated with qutenza, ischemia, substance p and calcitonin gene-related peptide
11) Confidence 0.81 Published 1999 Journal Scand. Cardiovasc. J. Section Abstract Doc Link 10540919 Disease Relevance 0.58 Pain Relevance 0.63
In primary headaches, there is a clear association between head pain and the release of the neuropeptide calcitonin gene-related peptide (CGRP).
Localization (release) of CGRP in head associated with neuropeptide, headache and calcitonin gene-related peptide
12) Confidence 0.81 Published 2001 Journal CNS Drugs Section Abstract Doc Link 11602001 Disease Relevance 0.55 Pain Relevance 1.14
BACKGROUND: Capsaicin has been shown to exert direct vasodilating effects through increased calcitonin gene-related peptide (CGRP) release.
Localization (release) of CGRP associated with qutenza and calcitonin gene-related peptide
13) Confidence 0.81 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15475832 Disease Relevance 0.07 Pain Relevance 0.26
BACKGROUND: Capsaicin has been shown to exert direct vasodilating effects through increased calcitonin gene-related peptide (CGRP) release.
Localization (release) of calcitonin gene-related peptide associated with qutenza and calcitonin gene-related peptide
14) Confidence 0.81 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15475832 Disease Relevance 0.07 Pain Relevance 0.26
In primary headaches, there is a clear association between the headache and the release of calcitonin gene-related peptide (CGRP) but not with other neuronal messengers.
Localization (release) of CGRP in neuronal associated with headache and calcitonin gene-related peptide
15) Confidence 0.81 Published 2007 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 17691979 Disease Relevance 0.87 Pain Relevance 1.20
In primary headaches, there is a clear association between the headache and the release of calcitonin gene-related peptide (CGRP), but not other neuronal messengers.
Localization (release) of CGRP in neuronal associated with headache and calcitonin gene-related peptide
16) Confidence 0.81 Published 2003 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 12783573 Disease Relevance 0.88 Pain Relevance 1.21
Capsaicin releases calcitonin gene-related peptide from the human iris and ciliary body in vitro.
Localization (releases) of calcitonin gene-related peptide in ciliary body associated with qutenza and calcitonin gene-related peptide
17) Confidence 0.81 Published 1992 Journal Regul. Pept. Section Title Doc Link 1280843 Disease Relevance 0.10 Pain Relevance 0.75
Cutaneous sensory stimulation leading to facial flushing and release of calcitonin gene-related peptide.
Localization (release) of calcitonin associated with increased venous pressure under development and calcitonin gene-related peptide
18) Confidence 0.81 Published 1992 Journal Cephalalgia Section Title Doc Link 1559259 Disease Relevance 0.77 Pain Relevance 0.75
During a migraine attack, there is a release of CGRP in conjunction with the head pain, and triptan administration abolishes both the CGRP release and the pain at the same time.
Localization (release) of CGRP in head associated with pain, migraine, triptan, headache and calcitonin gene-related peptide
19) Confidence 0.81 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11245850 Disease Relevance 0.48 Pain Relevance 0.94
In order to elucidate the mechanism of endogenous CGRP release, we have used a multiple site 133Xe clearance technique to measure local blood flow changes in response to agents injected intradermally in the rabbit.
Localization (release) of CGRP in blood associated with calcitonin gene-related peptide
20) Confidence 0.81 Published 1993 Journal Agents Actions Section Abstract Doc Link 8317313 Disease Relevance 0.06 Pain Relevance 0.55

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox