INT62610

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Context Info
Confidence 0.56
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.64
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) endosome (Ntrk1) aging (Ntrk1)
plasma membrane (Ntrk1) cytoplasm (Ntrk1)
Anatomy Link Frequency
nerve 2
spinal 1
spinal cord 1
Ntrk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 2 99.84 Very High Very High Very High
Nerve growth factor 9 99.80 Very High Very High Very High
Spinal cord 4 99.68 Very High Very High Very High
Pain 9 99.44 Very High Very High Very High
nociceptor 6 99.44 Very High Very High Very High
central pain 2 95.36 Very High Very High Very High
dorsal root ganglion 4 94.88 High High
Hsan 1 91.52 High High
qutenza 4 82.80 Quite High
Inflammation 7 81.12 Quite High
Disease Link Frequency Relevance Heat
Hypohidrosis 1 95.44 Very High Very High Very High
Pain 7 95.04 Very High Very High Very High
Ganglion Cysts 4 94.40 High High
Hereditary Sensory And Autonomic Neuropathies 4 91.52 High High
Diabetic Nephropathy 2 88.68 High High
INFLAMMATION 4 81.12 Quite High
Hyperalgesia 8 80.08 Quite High
Sleep Disorders 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
K252a, an inhibitor of trk phosphorylation and nerve growth factor signal transduction in PC12 cells, blocked nerve growth factor-induced responses in cultured adult rat dorsal root ganglion sensory neurones.
Phosphorylation (phosphorylation) of trk in nerve associated with ganglion cysts, dorsal root ganglion and nerve growth factor
1) Confidence 0.56 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8667012 Disease Relevance 0.24 Pain Relevance 0.69
Phosphorylation of a subunit of N-methyl-D-aspartate (NMDA) receptor by protein tyrosine kinase (PTK) Src or Trk is known to enhance its channel activity.
Phosphorylation (Phosphorylation) of Trk
2) Confidence 0.48 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12754057 Disease Relevance 0.53 Pain Relevance 0.51
Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn.
Phosphorylation (phosphorylation) of Trk in spinal associated with nociceptor and spinal dorsal horn
3) Confidence 0.09 Published 2002 Journal Mol. Cell. Neurosci. Section Title Doc Link 12504600 Disease Relevance 0.17 Pain Relevance 0.93
We found that noxious chemical, mechanical, or thermal stimuli, but not innocuous stimuli, caused Trk phosphorylation in the spinal cord.
Phosphorylation (phosphorylation) of Trk in spinal cord associated with spinal cord
4) Confidence 0.09 Published 2002 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12504600 Disease Relevance 0.17 Pain Relevance 0.42
Mutations in the neurotrophic tyrosine kinase receptor type 1 (NTRK1), a receptor in the neurotrophin signaling pathway phosphorylated in response to nerve growth factor, are associated with this disorder.
Phosphorylation (phosphorylated) of kinase receptor type 1 in nerve associated with nerve growth factor
5) Confidence 0.07 Published 2008 Journal Neurogenetics Section Abstract Doc Link 18322713 Disease Relevance 0.53 Pain Relevance 0.14

General Comments

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