INT62611

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.82
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 1.12
Pain Relevance 5.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
Nerve 3
DRG 2
neuronal 1
sensory neurons 1
skin 1
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 275 100.00 Very High Very High Very High
qutenza 17 100.00 Very High Very High Very High
lidocaine 4 97.68 Very High Very High Very High
dorsal root ganglion 4 95.84 Very High Very High Very High
Neuropathic pain 10 93.52 High High
local anesthetic 14 90.64 High High
TRP channel 1 89.44 High High
Sciatic nerve 45 87.84 High High
Pain management 1 84.76 Quite High
IPN 2 81.96 Quite High
Disease Link Frequency Relevance Heat
Injury 51 96.88 Very High Very High Very High
Ganglion Cysts 4 95.36 Very High Very High Very High
Neuropathic Pain 18 93.52 High High
Nociception 34 90.32 High High
Pain 41 84.32 Quite High
Inflammatory Pain 2 81.96 Quite High
Hyperalgesia 23 75.00 Quite High
Apoptosis 4 63.04 Quite High
Cough 2 50.00 Quite Low
Airway Obstruction 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, both NGF and phosphorylation of trkA increased significantly in DRGs, with a marginal appearance of phosphorylated trkA in axons.
Phosphorylation (phosphorylation) of NGF
1) Confidence 0.82 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 14664808 Disease Relevance 0.30 Pain Relevance 0.13
Bioactivity assay of NGF on laminin in vitro
Phosphorylation (assay) of NGF associated with nerve growth factor
2) Confidence 0.81 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0 Pain Relevance 0.61
NGF phosphorylated only one whereas epidermal growth factor phosphorylated both isoforms of ShcC in DRG cultures.
Phosphorylation (phosphorylated) of NGF in DRG associated with nerve growth factor
3) Confidence 0.79 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9753087 Disease Relevance 0 Pain Relevance 0.38
Different isoforms of ShcA were phosphorylated in response to NGF in DRG and PC12 cells.
Phosphorylation (phosphorylated) of NGF in DRG associated with nerve growth factor
4) Confidence 0.79 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9753087 Disease Relevance 0 Pain Relevance 0.38
ERK and STAT3 phosphorylation in sensory neurons during capsaicin-induced impairment and nerve growth factor treatment.
Phosphorylation (phosphorylation) of nerve growth factor in sensory neurons associated with nerve growth factor and qutenza
5) Confidence 0.71 Published 2005 Journal Pharmacology Section Title Doc Link 16141720 Disease Relevance 0.10 Pain Relevance 0.73
A large-molecular-weight form of NGF, approximately 75 kd, was found in normal skin.
Phosphorylation (form) of NGF in skin
6) Confidence 0.63 Published 2007 Journal Anesthesiology Section Body Doc Link 17585224 Disease Relevance 0 Pain Relevance 0
NGF showed a maximal Erk1/2 phosphorylation after 15 min maintaining a sustained high phosphorylation status thereafter (Figure 2H).
Phosphorylation (phosphorylation) of NGF
7) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0 Pain Relevance 0
Interestingly, NGF induced a more long-lasting phosphorylation, with translocation of the active forms into the nucleus and activation of the expression of specific neuronal genes.
Phosphorylation (phosphorylation) of NGF in neuronal associated with nerve growth factor
8) Confidence 0.52 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.12 Pain Relevance 0.17
K252a, an inhibitor of trk phosphorylation and nerve growth factor signal transduction in PC12 cells, blocked nerve growth factor-induced responses in cultured adult rat dorsal root ganglion sensory neurones.
Phosphorylation (phosphorylation) of nerve growth factor in nerve associated with ganglion cysts, dorsal root ganglion and nerve growth factor
9) Confidence 0.48 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8667012 Disease Relevance 0.25 Pain Relevance 0.70
Exposure to NGF also increased p38 MAPK phosphorylation, but pretreatment with the p38 MAPK inhibitor, SB203580, did not affect either the NGF-enhanced cough or airway obstruction despite preventing the NGF-induced elevation in p38 MAPK phosphorylation.
Phosphorylation (phosphorylation) of NGF-induced
10) Confidence 0.42 Published 2009 Journal Thorax Section Body Doc Link 19497920 Disease Relevance 0 Pain Relevance 0
Nerve growth factor (NGF) contributes to the sympathetic sprouting, and NGF signaling starts with NGF-stimulated autophosphorylation of TrkA, which is a high affinity receptor of NGF.
Phosphorylation (autophosphorylation) of NGF in Nerve associated with nerve growth factor
11) Confidence 0.24 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16428543 Disease Relevance 0.09 Pain Relevance 1.11
Nerve growth factor (NGF) contributes to the sympathetic sprouting, and NGF signaling starts with NGF-stimulated autophosphorylation of TrkA, which is a high affinity receptor of NGF.
Phosphorylation (autophosphorylation) of NGF in Nerve associated with nerve growth factor
12) Confidence 0.24 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16428543 Disease Relevance 0.09 Pain Relevance 1.09
To select a peptide inhibiting TrkA activity, we examined the effect of cell-penetrating peptides on tyrosine kinase activity of recombinant TrkA in vitro and studied their effects on NGF-stimulated neurite outgrowth and protein phosphorylation in PC12 cells.
Phosphorylation (phosphorylation) of NGF in neurite associated with nerve growth factor
13) Confidence 0.07 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18187921 Disease Relevance 0.17 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox