INT62629

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Context Info
Confidence 0.76
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 11.86
Pain Relevance 16.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) plasma membrane (CNR1) response to stress (CNR1)
signal transducer activity (CNR1)
Anatomy Link Frequency
enteric nervous system 3
hippocampus 2
neuronal 2
dorsal root ganglia 2
plasma 1
CNR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 426 100.00 Very High Very High Very High
Endocannabinoid 334 100.00 Very High Very High Very High
Cannabinoid receptor 199 100.00 Very High Very High Very High
Dopamine 198 100.00 Very High Very High Very High
antagonist 158 100.00 Very High Very High Very High
agonist 147 100.00 Very High Very High Very High
Glutamate 36 100.00 Very High Very High Very High
Neurotransmitter 41 99.84 Very High Very High Very High
analgesia 16 99.64 Very High Very High Very High
anesthesia 1 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 20 99.82 Very High Very High Very High
Injury 19 99.82 Very High Very High Very High
Prostate Cancer 42 99.32 Very High Very High Very High
Urological Neuroanatomy 1 99.14 Very High Very High Very High
Nociception 14 98.64 Very High Very High Very High
Death 30 97.80 Very High Very High Very High
Frailty 228 97.56 Very High Very High Very High
Ganglion Cysts 23 97.52 Very High Very High Very High
Rheumatoid Arthritis 200 97.28 Very High Very High Very High
Pain 200 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, CB1-cannabinoid receptors (CB1-R) were immunohistochemically localized within the enteric nervous system of the pig, an omnivorous species whose digestive tract is functionally similar to humans.
Localization (localized) of CB1-cannabinoid in enteric nervous system associated with cannabinoid receptor
1) Confidence 0.76 Published 2000 Journal Cell Tissue Res. Section Abstract Doc Link 11079717 Disease Relevance 0.09 Pain Relevance 0.18
In this study, CB1-cannabinoid receptors (CB1-R) were immunohistochemically localized within the enteric nervous system of the pig, an omnivorous species whose digestive tract is functionally similar to humans.
Localization (localized) of CB1-R in enteric nervous system associated with cannabinoid receptor
2) Confidence 0.76 Published 2000 Journal Cell Tissue Res. Section Abstract Doc Link 11079717 Disease Relevance 0.09 Pain Relevance 0.18
More specifically, endocannabinoids activate the pre-synaptic CB1 receptor, inhibiting release of both excitatory and inhibitory neurotransmitters in the CNS and peripheral nervous system (ie, glutamate and gamma aminobutyric acid [GABA], respectively) (Schlicker and Kathmann 2001; Howlett et al 2002).
Localization (release) of CB1 receptor in peripheral nervous system associated with endocannabinoid, gaba, glutamate, neurotransmitter, peripheral nervous system and central nervous system
3) Confidence 0.73 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503671 Disease Relevance 0.43 Pain Relevance 0.96
Corneal epithelial injury induces release of endogenous metabolites that are cannabinoid receptor 1 (CB1) and transient receptor potential vanilloid 1 (TRPV1) agonists.
Localization (release) of CB1 associated with cannabinoid receptor, injury and agonist
4) Confidence 0.73 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.19 Pain Relevance 0.45
Corneal epithelial injury induces release of endogenous metabolites that are cannabinoid receptor 1 (CB1) and transient receptor potential vanilloid 1 (TRPV1) agonists.
Localization (release) of cannabinoid receptor 1 associated with cannabinoid receptor, injury and agonist
5) Confidence 0.73 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.19 Pain Relevance 0.45
Confocal microscopy analysis reveals that the intracellular CB1 receptors are localized to vesicles, which implies that the receptors are "trafficking" or undergoing a continuous cycle of internalization and membrane relocalization.
Localization (localized) of CB1 in vesicles
6) Confidence 0.73 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17251327 Disease Relevance 0.41 Pain Relevance 0.24
However, studies of the endogenously expressed CB1 receptors using specific antibodies have shown that the there is usually a distinct intracellular, vesicular localization of the CB1 receptor.
Localization (localization) of CB1
7) Confidence 0.73 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17251327 Disease Relevance 0.46 Pain Relevance 0.27
Localization of CB1-cannabinoid receptor immunoreactivity in the porcine enteric nervous system.
Localization (Localization) of CB1-cannabinoid in enteric nervous system associated with cannabinoid receptor and cannabinoid
8) Confidence 0.71 Published 2000 Journal Cell Tissue Res. Section Title Doc Link 11079717 Disease Relevance 0.09 Pain Relevance 0.24
In turn, the activated post-synaptic neuron releases endocannabinoids such as anandamide (Freund et al 2003; Navari 2003; Piomelli 2003) These endogenous CB1 ligands then diffuse back and bind to the pre-synaptic CB1 receptor (Piomelli 2003).
Localization (releases) of CB1 in neuron associated with endocannabinoid
9) Confidence 0.69 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503671 Disease Relevance 0.34 Pain Relevance 0.92
Cannabinoid CB1 receptors and vanilloid VR1 receptors are co-localized to some extent in sensory neurons of the spinal cord and dorsal root ganglia.
Localization (co-localized) of CB1 in dorsal root ganglia associated with cannabinoid and spinal cord
10) Confidence 0.69 Published 2003 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 12737320 Disease Relevance 0 Pain Relevance 0.35
Rabbit anti human-CB1 and anti human-CB2 antibodies (Cayman Chemical, Ann Arbor, MI, USA) were used at a dilution of 1?
Localization (human) of CB1
11) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.61 Pain Relevance 0.58
Cell homogenates were subjected to 10% SDS-PAGE (50 µg/lane) under reducing conditions, then gels were electroblotted onto 0.45-µm nitrocellulose filters (Bio-Rad, Hercules, CA) and were immunoreacted with anti-CB1R (1?
Localization (electroblotted) of CB1R
12) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0 Pain Relevance 0.04
Our data not only demonstrate by means of several techniques that CB2R is by far more abundant than CB1R in primary human T-cells, but also that both receptors are recruited on the cell surface upon activation.
Localization (abundant) of CB1R in T-cells
13) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0.07 Pain Relevance 0.07
Last, the presence of a cannabinoid receptor in selected evolutionary diverse organisms indicates that this signaling system has been conserved for more than 500 million years.
Localization (presence) of cannabinoid receptor associated with cannabinoid receptor
14) Confidence 0.61 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8702604 Disease Relevance 0 Pain Relevance 0.31
Immunoreactivity for CB1, NAPE-PLD, and FAAH was localized in the postacrosomal region and in the midpiece, whereas for TRPV1, it was restricted to the postacrosomal region.
Localization (localized) of CB1 associated with cannabinoid receptor
15) Confidence 0.61 Published 2009 Journal Endocrinology Section Abstract Doc Link 19608651 Disease Relevance 0.05 Pain Relevance 0.37
Here, we report the presence of both the CB1 and CB2 receptors in the synovia of patients with end-stage OA and RA, suggesting that this system may play a role in these pathological conditions.
Localization (presence) of CB1 associated with rheumatoid arthritis and osteoarthritis
16) Confidence 0.60 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 1.50 Pain Relevance 1.00
CB1- and CB2-receptors were localized in the human pancreas using immunohistochemistry.
Localization (localized) of CB1 in pancreas
17) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.69 Pain Relevance 0.60
The well-described presynaptic localization of CB1 receptor contrasts with the presence of this receptor into submucosal ganglion cell bodies, as was described in the human and mouse colon.[20], [21], [37] Our results revealed similar CB2 expression in the mucosal epithelial cells from normal patient samples in a previous human colonic study that, using different CB2 antibodies, supports our immunohistochemical data.[20] Of note, we observed strong CB2 expression in the Paneth cells at the bottom of the crypts.
Localization (localization) of CB1 receptor in colon associated with ganglion cysts
18) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.19 Pain Relevance 0.05
CB1 could be modulating colonic neuronal input and secretion while CB2 may participate in colonic immunomodulation.
Localization (secretion) of CB1 in neuronal
19) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.26 Pain Relevance 0.13
Correlation of CB1IR and pEGFR-IR in prostate cancer samples
Localization (Correlation) of CB1IR associated with prostate cancer
20) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009725 Disease Relevance 1.20 Pain Relevance 0

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