INT62630

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 4
Speculated 7
Reported most in Abstract
Documents 86
Total Number 93
Disease Relevance 40.34
Pain Relevance 51.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) plasma membrane (CNR1) response to stress (CNR1)
signal transducer activity (CNR1)
Anatomy Link Frequency
hippocampus 3
Spinal 3
leucocytes 3
CNS 2
HCEC 2
CNR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 673 100.00 Very High Very High Very High
Cannabinoid receptor 381 100.00 Very High Very High Very High
Analgesic 52 100.00 Very High Very High Very High
Hippocampus 25 100.00 Very High Very High Very High
analgesia 24 100.00 Very High Very High Very High
neuralgia 6 100.00 Very High Very High Very High
Delta opioid receptors 1 100.00 Very High Very High Very High
Endocannabinoid 741 99.98 Very High Very High Very High
agonist 308 99.96 Very High Very High Very High
cannabis 167 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 758 100.00 Very High Very High Very High
Nicotine Addiction 28 99.98 Very High Very High Very High
Vomiting 519 99.92 Very High Very High Very High
Migraine Disorders 12 99.84 Very High Very High Very High
Neuropathic Pain 50 99.82 Very High Very High Very High
Pain 140 99.80 Very High Very High Very High
Colitis 60 99.72 Very High Very High Very High
Anxiety Disorder 28 99.68 Very High Very High Very High
Nociception 16 99.64 Very High Very High Very High
Hypersensitivity 4 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistently, in vivo studies have shown that cannabinoids reduce gastrointestinal transit in rodents through activation of CB1, but not CB2, receptors.
Positive_regulation (activation) of CB1 associated with cannabinoid
1) Confidence 0.70 Published 2008 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 18924447 Disease Relevance 0.51 Pain Relevance 0.57
Induction of the CB1 receptor also resulted in an increase of basal [(35)S]guanosine 5'-3-O-(thio)triphosphate (GTPgammaS) binding and thereby a greatly reduced capacity of DAMGO to further stimulate [(35)S]GTPgammaS binding.
Positive_regulation (Induction) of CB1
2) Confidence 0.69 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.77
The CB1 receptor in the guinea-pig hippocampus is located presynaptically, is activated by endogenous cannabinoids and may be negatively coupled to adenylyl cyclase.
Positive_regulation (activated) of CB1 receptor in hippocampus associated with cannabinoid and hippocampus
3) Confidence 0.68 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9402037 Disease Relevance 0 Pain Relevance 0.45
The effect of anandamide, which activates both the cannabinoid 1 (CB1) receptor and the vanilloid receptor 1 (VR1), was studied on calcitonin gene-related peptide (CGRP) release from cultured primary sensory neurons, the majority of which coexpress the CB1 receptor and VR1.
Positive_regulation (activates) of CB1 in primary sensory neurons associated with cannabinoid and calcitonin gene-related peptide
4) Confidence 0.67 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12823468 Disease Relevance 0 Pain Relevance 0.48
On the contrary, activation of CB1 receptors has appetite stimulant, antiemetic and analgesic properties, that deserve to be studied for putative therapeutical uses.
Positive_regulation (activation) of CB1 associated with appetite loss, analgesic and vomiting
5) Confidence 0.67 Published 2007 Journal Vertex Section Abstract Doc Link 17356719 Disease Relevance 0.49 Pain Relevance 0.27
The activation of the CB1 receptor leads to an induction of sleep, this effect is blocked via the selective antagonist.
Positive_regulation (activation) of CB1 associated with antagonist
6) Confidence 0.66 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18514375 Disease Relevance 0.10 Pain Relevance 0.60
We determined the functional contributions by CB1 and TRPV1 activation to eliciting responses underlying wound healing in human corneal epithelial cells (HCEC).
Spec (determined) Positive_regulation (activation) of CB1 in HCEC associated with cannabinoid receptor and wound healing
7) Confidence 0.63 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.19 Pain Relevance 0.54
Increased cannabinoid receptor 1-immunoreactive nerve fibers in overactive and painful bladder disorders and their correlation with symptoms.
Positive_regulation (Increased) of cannabinoid receptor in bladder associated with pain, cannabinoid receptor and bladder disease
8) Confidence 0.61 Published 2010 Journal Urology Section Title Doc Link 20346490 Disease Relevance 0.28 Pain Relevance 0.45
In addition, it has been shown that chronic marijuana smoking increases CB1R and CB2R mRNA in peripheral blood mononuclear cells [8].
Positive_regulation (increases) of CB1R in blood associated with nicotine addiction
9) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0.10 Pain Relevance 0.23
Activation of CB1 receptors is associated predominantly with a dampening down of neuronal excitability, whereas activation of CB2 receptors is associated with decreases in immune cell function, including attenuated cytokine release [9,17].
Positive_regulation (Activation) of CB1 in immune cell associated with neuronal excitability and cytokine
10) Confidence 0.55 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0.78 Pain Relevance 0.73
It is concluded that unlike capsaicin, anandamide inhibits more effectively Adelta-fibre than C-fibre-mediated excitatory transmission in the SG, possibly through the activation of the cannabinoid receptor.
Spec (possibly) Positive_regulation (activation) of cannabinoid receptor associated with substantia gelatinosa, c fibre, cannabinoid receptor, qutenza and adelta
11) Confidence 0.53 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11872246 Disease Relevance 0 Pain Relevance 1.11
In animal models endogenous cannabinoids have an inhibitory effect on trigeminovascular activation through the cannabinoid receptor 1 (CB1), although there is no evidence of the potential role of CB1 in human migraine.
Positive_regulation (activation) of cannabinoid receptor 1 associated with cannabinoid receptor, migraine and cannabinoid
12) Confidence 0.50 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19539700 Disease Relevance 0.69 Pain Relevance 0.73
In animal models endogenous cannabinoids have an inhibitory effect on trigeminovascular activation through the cannabinoid receptor 1 (CB1), although there is no evidence of the potential role of CB1 in human migraine.
Positive_regulation (activation) of CB1 associated with cannabinoid receptor, migraine and cannabinoid
13) Confidence 0.50 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19539700 Disease Relevance 0.69 Pain Relevance 0.74
These results suggest a significant effect of CNR1 on migraine headaches that might be related to the alteration of peripheral trigeminovascular activation.
Positive_regulation (effect) of CNR1 associated with migraine and headache
14) Confidence 0.50 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19539700 Disease Relevance 1.19 Pain Relevance 1.33
Variations in the cannabinoid receptor 1 gene predispose to migraine.
Positive_regulation (Variations) of cannabinoid receptor 1 associated with cannabinoid receptor and migraine
15) Confidence 0.50 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19539700 Disease Relevance 1.05 Pain Relevance 1.10
Selective activation of peripheral cannabinoid CB1 receptors has the potential to become a valuable therapy for chronic pain conditions as long as central nervous system effects are attenuated.
Positive_regulation (activation) of CB1 in central nervous system associated with lasting pain, cannabinoid and central nervous system
16) Confidence 0.50 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 17630726 Disease Relevance 0.10 Pain Relevance 0.49
These functionalities suggest a role for the cannabinoid receptor (CB) in mediating biological effects.
Positive_regulation (role) of cannabinoid receptor associated with cannabinoid receptor
17) Confidence 0.50 Published 2009 Journal J Med Food Section Abstract Doc Link 20041802 Disease Relevance 0.10 Pain Relevance 0.31
AJA binds weakly to CB1 only at concentrations many fold higher than its therapeutic range, and is, therefore, completely free of psychotropic effects in both normal subjects and pain patients suggesting the involvement of a target site other than CB1.
Spec (suggesting) Positive_regulation (suggesting) of CB1 associated with pain
18) Confidence 0.49 Published 2005 Journal Life Sci. Section Abstract Doc Link 16005906 Disease Relevance 0.28 Pain Relevance 0.43
CB1 receptor mediated analgesia from the Nucleus Reticularis Gigantocellularis pars alpha is activated in an animal model of neuropathic pain.
Positive_regulation (activated) of CB1 receptor in Nucleus associated with analgesic, neuropathic pain and analgesia
19) Confidence 0.49 Published 2001 Journal Brain Res. Section Title Doc Link 11457432 Disease Relevance 0.17 Pain Relevance 0.90
These data suggest that activation of cannabinoid CB1 receptor subtypes in GiA leads to behavioural analgesia.
Positive_regulation (activation) of CB1 receptor associated with cannabinoid and analgesia
20) Confidence 0.49 Published 2001 Journal Brain Res. Section Abstract Doc Link 11457432 Disease Relevance 0.16 Pain Relevance 0.86

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