INT62652

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Context Info
Confidence 0.47
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.79
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR7) signal transducer activity (HTR7)
Anatomy Link Frequency
brain 1
platelet 1
HTR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 27 100.00 Very High Very High Very High
antagonist 22 99.96 Very High Very High Very High
5HT 1 99.84 Very High Very High Very High
agonist 49 99.56 Very High Very High Very High
Potency 6 98.72 Very High Very High Very High
Analgesic 8 98.04 Very High Very High Very High
Pain 4 91.72 High High
depression 115 91.32 High High
Migraine 9 89.60 High High
Sumatriptan 5 88.24 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 106 99.62 Very High Very High Very High
Schizophrenia 2 98.96 Very High Very High Very High
Vomiting 2 92.68 High High
Ataxia 3 92.16 High High
Pain 4 91.72 High High
Depression 127 91.32 High High
Headache 2 89.60 High High
Machado-joseph Disease 2 86.56 High High
Coronary Artery Disease 25 85.60 High High
Thrombosis 4 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory potency of the drugs was significantly correlated with their affinity for 5-HTID receptors in human brain and for cloned human 5-HT1D alpha and 5-HT1D beta receptors, but not with their affinity for 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT5B and 5-HT7 receptors.
5-HT7 Neg (not) Binding (affinity) of in brain associated with potency
1) Confidence 0.47 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.49
Compounds interacting with 5-HT1F, 5-HT2C, 5-HT6 and 5-HT7 receptors are currently under investigation and may prove to have important therapeutic applications in the future.
5-HT7 Binding (interacting) of
2) Confidence 0.47 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11888547 Disease Relevance 0.60 Pain Relevance 0.26
When serotonin binds to 5-hydroxytryptamine-2 (5HT-2) receptors on platelets, it causes the release of procoagulant factors stored in the platelets and enhances platelet aggregation, leading to clot formation.
5-hydroxytryptamine Binding (binds) of in platelet associated with 5ht and serotonin
3) Confidence 0.47 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874336 Disease Relevance 1.19 Pain Relevance 0.62
Further, all four ergolines possessed affinity for the human 5-HT7 receptor, and LY215840 had the highest 5-HT7 receptor affinity (Ki = 14.7 nM).
5-HT7 Binding (affinity) of
4) Confidence 0.36 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8667223 Disease Relevance 0 Pain Relevance 0.24
Tandospirone citrate (tandospirone) is an anti-anxiety drug that acts by combining with serotonin receptor (5-hydroxytryptamine-1 A [5-HT1A]).
5-hydroxytryptamine Binding (combining) of associated with anxiety disorder and serotonin
5) Confidence 0.36 Published 2002 Journal Psychiatry Clin. Neurosci. Section Abstract Doc Link 11952922 Disease Relevance 0.82 Pain Relevance 0.17
Decreased agonist, but not antagonist, binding to the naturally occurring Thr92Lys variant of the h5-HT7(a) receptor.
5-HT7 Binding (binding) of associated with antagonist and agonist
6) Confidence 0.36 Published 2005 Journal Neurochem. Int. Section Title Doc Link 15896881 Disease Relevance 0 Pain Relevance 0.27
The 5-HT7 receptor: a target for novel therapeutic avenues?
5-HT7 Binding (receptor) of
7) Confidence 0.36 Published 1998 Journal IDrugs Section Title Doc Link 18465553 Disease Relevance 0.08 Pain Relevance 0.08
Association between 5-hydroxytryptamine 2A receptor gene polymorphism and postoperative analgesic requirements after major abdominal surgery.
5-hydroxytryptamine Binding (Association) of associated with analgesic
8) Confidence 0.36 Published 2010 Journal Neurosci. Lett. Section Title Doc Link 20478362 Disease Relevance 0.09 Pain Relevance 0.86
So far, there have been no reports on GIP interactions with any 5–HT4 or 5–HT7 receptor splice variants in human tissue.
HT7 receptor Neg (no) Binding (interactions) of
9) Confidence 0.09 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0 Pain Relevance 0.07

General Comments

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