INT62653

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Context Info
Confidence 0.54
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.23
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C19) oxidoreductase activity (CYP2C19) endoplasmic reticulum (CYP2C19)
enzyme binding (CYP2C19)
Anatomy Link Frequency
liver 1
CYP2C19 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 31 97.00 Very High Very High Very High
methadone 91 96.68 Very High Very High Very High
Bioavailability 11 84.16 Quite High
Serotonin 44 83.36 Quite High
withdrawal 37 81.04 Quite High
tramadol 4 80.96 Quite High
tricyclic antidepressant 24 79.88 Quite High
Desipramine 3 79.68 Quite High
noradrenaline 26 75.28 Quite High
antidepressant 39 75.00 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 15 97.64 Very High Very High Very High
Schizophrenia 37 93.76 High High
Hemorrhage 2 93.56 High High
Serotonin Syndrome 5 73.60 Quite High
Arrhythmia Under Development 7 71.36 Quite High
Substance Withdrawal Syndrome 15 65.16 Quite High
INFLAMMATION 2 63.76 Quite High
Psychosis 12 63.04 Quite High
Pressure And Volume Under Development 3 58.08 Quite High
Dizziness 5 55.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although CYP2C9, CYP2C19 and CYP2E1 are also induced, no specific inducers of CYP2D6 have yet been identified clearly.
Positive_regulation (induced) of CYP2C19
1) Confidence 0.54 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2584094 Disease Relevance 0.10 Pain Relevance 0.10
In these studies, the inhibition profiles of a set of 24 inhibitors were paneled against the CYP2C19 substrate probes (S)-mephenytoin, (R)-omeprazole, (S)-omeprazole, and (S)-fluoxetine, on the basis of their inclusion in recent U.S.
Positive_regulation (paneled) of CYP2C19 associated with fluoxetine
2) Confidence 0.50 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 18048485 Disease Relevance 0 Pain Relevance 0.22
However, the proton pump inhibitors are deactivated, and a significant improvement of therapy with proton pump inhibitors may be obtained by genotyping for CYP2C19 [31].


Positive_regulation (genotyping) of CYP2C19
3) Confidence 0.47 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.16 Pain Relevance 0.07
Melatonin was found to be almost exclusively metabolized by CYP1A2 to 6-hydroxymelatonin and N-acetylserotonin with a minimal contribution of CYP2C19.
Positive_regulation (contribution) of CYP2C19
4) Confidence 0.46 Published 2001 Journal J Clin Psychopharmacol Section Abstract Doc Link 11270913 Disease Relevance 0 Pain Relevance 0.27
The risk of pharmacokinetic drug-drug interactions may be low.175,219 Moreover, induction or inhibition of CYP2D6 or CYP2C19 has no significant effect on milnacipran.175
Positive_regulation (induction) of CYP2C19
5) Confidence 0.39 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.30 Pain Relevance 0.47
The mechanism may be its induction of CYP2C19 and intestinal p-glycoprotein [33•].
Positive_regulation (induction) of CYP2C19
6) Confidence 0.32 Published 2010 Journal Curr HIV/AIDS Rep Section Body Doc Link PMC2892618 Disease Relevance 0.20 Pain Relevance 1.23
As expected from in vivo panel studies, CYP2C19 in yeast was also very active in the N-demethylation (formation rate, 145 nmol/nmol of CYP per hr).
Positive_regulation (active) of CYP2C19
7) Confidence 0.22 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8667235 Disease Relevance 0 Pain Relevance 0.05
This suggests it is unlikely to interact with drugs that inhibit or induce these enzymes.33 Also, smoking should not affect its pharmacokinetics, like most antipsychotics except the CYP1A2 substrates clozapine and olanzapine whose clearance is affected by cigarette smoking and drugs that induce or inhibit CYP1A2.21 In vitro studies in human liver microsomes showed that iloperidone do not induce CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP3A4 and CYP3A5.33

Efficacy

Neg (not) Positive_regulation (induce) of CYP2C19 in liver associated with nicotine addiction
8) Confidence 0.18 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846148 Disease Relevance 0.48 Pain Relevance 0

General Comments

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