INT62669

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 6.89
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)
Anatomy Link Frequency
articular 1
joints 1
cartilage 1
bile 1
COL1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 1 99.52 Very High Very High Very High
dexamethasone 2 96.36 Very High Very High Very High
backache 1 96.28 Very High Very High Very High
endometriosis 13 93.72 High High
Osteoarthritis 370 90.56 High High
metalloproteinase 33 87.24 High High
cINOD 12 83.28 Quite High
rheumatoid arthritis 46 81.80 Quite High
Pain 61 80.32 Quite High
palliative 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Hypercalcemia 35 100.00 Very High Very High Very High
Metastasis 106 99.56 Very High Very High Very High
Breast Cancer 41 98.96 Very High Very High Very High
Head Trauma 7 98.40 Very High Very High Very High
Injury 20 97.32 Very High Very High Very High
Reprotox - General 1 7 97.08 Very High Very High Very High
Low Back Pain 2 96.28 Very High Very High Very High
Endometriosis (extended) 19 93.72 High High
Bone Fracture 4 92.88 High High
Cancer 15 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cross-linked carboxyterminal telopeptide of type I collagen and pyridinoline, which are parameters of bone resorption, was markedly elevated with low bone mineral density.
Positive_regulation (elevated) of type I collagen associated with hypercalcemia
1) Confidence 0.49 Published 2001 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 11483939 Disease Relevance 0.27 Pain Relevance 0.10
Carboxy-terminal telopeptide fragments of type I collagen
Positive_regulation (fragments) of type I collagen
2) Confidence 0.18 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.24 Pain Relevance 0.04
Breast cancer patients with bone metastases are characterised by increased levels of nonisomerised type I collagen fragments

Background

Positive_regulation (increased) of type I collagen associated with breast cancer and metastasis
3) Confidence 0.14 Published 2003 Journal Breast Cancer Res Section Title Doc Link PMC165019 Disease Relevance 0.87 Pain Relevance 0
Breast cancer patients with bone metastases are characterised by increased levels of nonisomerised type I collagen fragments

Background

Positive_regulation (levels) of type I collagen associated with breast cancer and metastasis
4) Confidence 0.14 Published 2003 Journal Breast Cancer Res Section Title Doc Link PMC165019 Disease Relevance 0.87 Pain Relevance 0
Moreover, such cultures generally progressed towards a mixed cartilage phenotype with the upregulation of type I collagen and type X collagen [35].
Positive_regulation (upregulation) of type I collagen in cartilage
5) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.06 Pain Relevance 0
Bone formation was investigated by measuring serum carboxyterminal propeptide of type I procollagen (PICP), Bone Gla Protein (BGP, osteocalcin), bone isoenzyme of alkaline phosphatase (BALP); bone resorption by measuring serum carboxyterminal telopeptide of type I collagen (ICTP), fasting urinary hydroxyproline/creatinine (OHPro/Cr) and calcium/creatinine (Ca/Cr).
Positive_regulation (measuring) of type I collagen associated with hypercalcemia
6) Confidence 0.08 Published 1995 Journal Anticancer Res. Section Abstract Doc Link 8669881 Disease Relevance 0.68 Pain Relevance 0
The results demonstrated: (a) that expression levels of the catabolic genes MMP-3 and MMP-13 were suppressed and (b) mRNA expression levels of anabolic genes of collagen II, SOX9 and aggrecan were increased.
Positive_regulation (increased) of collagen II
7) Confidence 0.07 Published 2009 Journal Phytochemistry Section Abstract Doc Link 19118849 Disease Relevance 0.26 Pain Relevance 0.32
A number of these compounds has already been tested in clinical trials, and data have shown that MMP inhibitors may produce musculoskeletal side effects characterized by joint stiffness, joint fibroplasias and accumulation of type I collagen in the affected joints [80].
Positive_regulation (accumulation) of type I collagen in joints
8) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.44 Pain Relevance 0.13
As type I collagen is the most abundant protein of the osteoid, we finally investigated whether gal-3 affects expression of the type I collagen ?
Positive_regulation (abundant) of type I collagen
9) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.19 Pain Relevance 0.09
In vitro, ascorbate and ascorbic acid increased protein and proteoglycan synthesis by articular chondrocytes [64,66,67] and increased the mRNA levels of type I and II collagen [64,68] and aggrecan and ?
Positive_regulation (increased) of type I and II collagen in articular
10) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779427 Disease Relevance 0.42 Pain Relevance 0.21
Thus, we assessed changes in the level of the carboxyterminal telopeptide of type-I collagen (ICTP), a bone resorption marker, before and after pamidronate administration in HRPC patients with increasing prostate-specific antigen (PSA) levels.
Positive_regulation (level) of type-I collagen associated with hypercalcemia and reprotox - general 1
11) Confidence 0.02 Published 2007 Journal Urol. Int. Section Abstract Doc Link 17495494 Disease Relevance 0.85 Pain Relevance 0.20
Selected dysregulated genes were randomly chosen and validated with RT-PCR and/or Northern/dot-blot analyses, and confirmed up-regulation of collagen alpha2 type I, 2.6-fold; bile salt export pump, 2.0-fold; and down-regulation of N-acetylglucosamine-6-O-sulfotransferase (important in synthesis of L-selectin ligands), 1.7-fold; glycodelin, 51.5-fold; integrin alpha2, 1.8-fold; and B61 (Ephrin A1), 4.5-fold.
Positive_regulation (up-regulation) of collagen alpha2 type I in bile associated with bile
12) Confidence 0.01 Published 2003 Journal Endocrinology Section Abstract Doc Link 12810542 Disease Relevance 0.72 Pain Relevance 0.23
Procollagen I (PICP) was significantly increased even in the 1st week, reaching its peak during the 2nd week after injury.
Positive_regulation (increased) of Procollagen I associated with injury
13) Confidence 0.01 Published 1996 Journal Unfallchirurg Section Abstract Doc Link 8850075 Disease Relevance 1.04 Pain Relevance 0.08

General Comments

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