INT62678

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 6.95
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (JAG1) structural molecule activity (JAG1) plasma membrane (JAG1)
Anatomy Link Frequency
neurite 1
JAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 41 99.84 Very High Very High Very High
Acupuncture 103 98.84 Very High Very High Very High
Clonidine 4 98.66 Very High Very High Very High
Gabapentin 3 98.58 Very High Very High Very High
Neuronal excitability 1 96.64 Very High Very High Very High
alcohol 37 94.76 High High
Dopamine 82 93.12 High High
gABA 24 89.12 High High
anesthesia 1 86.36 High High
Nucleus accumbens 46 83.24 Quite High
Disease Link Frequency Relevance Heat
Alagille Syndrome 98 100.00 Very High Very High Very High
Pressure And Volume Under Development 5 99.68 Very High Very High Very High
Injury 6 97.64 Very High Very High Very High
Pneumonia 1 96.88 Very High Very High Very High
Sepsis 1 96.44 Very High Very High Very High
Body Weight 20 95.56 Very High Very High Very High
Coagulation Disorder 1 95.36 Very High Very High Very High
Neuropathy 4 94.92 High High
Death 1 94.44 High High
Congenital Anomalies 82 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FIV-infected cultures exhibited viral Ags (p24 and envelope) in macrophages accompanied by neuronal injury, indicated by neurite retraction, neuronal loss and decreased soma size, compared with mock-infected (control) cultures.
Negative_regulation (exhibited) of Ags in neurite associated with alagille syndrome and injury
1) Confidence 0.41 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.42 Pain Relevance 0.12
Insertion of the Pentax-AWS was unaffected by the swelling and tracheal intubation was successful within 10 sec.
Neg (unaffected) Negative_regulation (unaffected) of Pentax-AWS associated with pressure and volume under development and alagille syndrome
2) Confidence 0.37 Published 2010 Journal Masui Section Abstract Doc Link 20420136 Disease Relevance 0.70 Pain Relevance 0.13
The duration of ICU stay, prevention of AWS, incidence of tracheobronchitis and major intercurrent complications such as pneumonia, sepsis, cardiac disorders, bleeding disorders and death were documented.
Negative_regulation (prevention) of AWS associated with coagulation disorder, alagille syndrome, pneumonia, death and sepsis
3) Confidence 0.37 Published 1995 Journal Br J Anaesth Section Abstract Doc Link 8672322 Disease Relevance 1.26 Pain Relevance 0.47
Ideally, AWS should be prevented by adequate prophylaxis.
Negative_regulation (prevented) of AWS associated with alagille syndrome
4) Confidence 0.37 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10195555 Disease Relevance 0.62 Pain Relevance 0.20
AWS was prevented in all 11 patients.
Negative_regulation (prevented) of AWS
5) Confidence 0.28 Published 1998 Journal Intensive Care Med Section Body Doc Link 9660261 Disease Relevance 0 Pain Relevance 0
Besides the use of clomethiazole, clonidine, and benzodiazepines, there is another possible way to prevent AWS by deliberate administration of ethanol.
Spec (possible) Negative_regulation (prevent) of AWS associated with alagille syndrome and clonidine
6) Confidence 0.20 Published 1998 Journal Intensive Care Med Section Abstract Doc Link 9660261 Disease Relevance 0.28 Pain Relevance 0.31
Because Japanese individuals are generally shorter than Caucasians, standard cut-off values for reductions in height or AHD are not generally applicable to Japanese populations.
Negative_regulation (reductions) of AHD associated with alagille syndrome
7) Confidence 0.20 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2613887 Disease Relevance 0.48 Pain Relevance 0
In the simplest model comprising AHD and WOD only (Model 1), the regression coefficients were 1.329 and 1.614, respectively, and the AIC was calculated to be 96.28.
Negative_regulation (comprising) of AHD associated with alagille syndrome
8) Confidence 0.20 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2613887 Disease Relevance 1.09 Pain Relevance 0
Indeed, available studies have demonstrated that clomethiazole, gabapentin and gamma hydroxybutyrate (GHB) present a similar efficacy to BDZs in suppressing AWS.
Negative_regulation (suppressing) of AWS associated with alagille syndrome and gabapentin
9) Confidence 0.13 Published 2010 Journal Curr. Pharm. Des. Section Abstract Doc Link 20482512 Disease Relevance 0.64 Pain Relevance 1.02
Treatment of acupuncture at Zusanli or Sanyinjiao points during withdrawal period inhibited AWS and also prevented the expected increase in FLI of rats exposed to chronic ethanol.
Negative_regulation (inhibited) of AWS associated with alagille syndrome, acupuncture and withdrawal
10) Confidence 0.02 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529396 Disease Relevance 0.45 Pain Relevance 1.26

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