INT62681

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 93
Total Number 95
Disease Relevance 66.97
Pain Relevance 15.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
plasma 6
body 5
fat 3
adipose tissue 3
chondrocyte 1
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 16 99.72 Very High Very High Very High
c fibre 58 99.70 Very High Very High Very High
Inflammation 360 99.56 Very High Very High Very High
qutenza 66 99.52 Very High Very High Very High
Pain 178 99.20 Very High Very High Very High
Kinase C 14 99.08 Very High Very High Very High
nociceptor 66 98.76 Very High Very High Very High
Chronic pancreatitis 14 98.72 Very High Very High Very High
isoflurane 7 98.38 Very High Very High Very High
Osteoarthritis 780 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 3903 100.00 Very High Very High Very High
Overnutrition 220 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 124 100.00 Very High Very High Very High
Natriuresis 68 100.00 Very High Very High Very High
Diabetes Mellitus 637 99.84 Very High Very High Very High
Apnoea 342 99.80 Very High Very High Very High
Cancer 136 99.80 Very High Very High Very High
Weight Loss 727 99.58 Very High Very High Very High
INFLAMMATION 430 99.56 Very High Very High Very High
Body Weight 287 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the first 2 h of surgery, the decrease in leptin parallels the increase in cortisol.
Negative_regulation (decrease) of leptin
1) Confidence 0.59 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10404818 Disease Relevance 0.40 Pain Relevance 0.16
Early in surgery the decrease in leptin parallels the increase in cortisol.
Negative_regulation (decrease) of leptin
2) Confidence 0.59 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10404818 Disease Relevance 0.24 Pain Relevance 0.13
In phase II, high dose fentanyl limited both the cortisol increase and the leptin decrease; thus, the ratio of cortisol increase to leptin decrease was similar for the cardiac patients and the hysterectomy patients.
Negative_regulation (decrease) of leptin
3) Confidence 0.59 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10404818 Disease Relevance 0.29 Pain Relevance 0.14
In phase II, high dose fentanyl limited both the cortisol increase and the leptin decrease; thus, the ratio of cortisol increase to leptin decrease was similar for the cardiac patients and the hysterectomy patients.
Negative_regulation (decrease) of leptin
4) Confidence 0.59 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10404818 Disease Relevance 0.34 Pain Relevance 0.15
Leptin levels decrease after short and long-term Auto-CPAP therapy were not statistically significant.


Negative_regulation (decrease) of Leptin
5) Confidence 0.59 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 1.39 Pain Relevance 0.08
On the one hand, there were significant reductions of amplitude, and on the other hand, a complete loss of LEP was found.
Negative_regulation (loss) of LEP
6) Confidence 0.58 Published 2003 Journal Orthopade Section Abstract Doc Link 14579016 Disease Relevance 0.40 Pain Relevance 0.40
Current studies have elucidated that some antihypertensives might be more relevant than others in terms of reducing leptin levels in obesity.
Negative_regulation (reducing) of leptin associated with obesity
7) Confidence 0.58 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 1.22 Pain Relevance 0.03
Fasters showed a more pronounced decrease of leptin (58% vs. 20%; P < 0.001) and a 17% increase of cortisol levels (P < 0.001).
Negative_regulation (decrease) of leptin
8) Confidence 0.58 Published 2006 Journal Nutr Neurosci Section Abstract Doc Link 17263085 Disease Relevance 0.32 Pain Relevance 0.07
This is the mechanism for reducing the level of leptin in the bloodstream and the corresponding reduction in the percentage of body fat.
Negative_regulation (reducing) of leptin in fat
9) Confidence 0.56 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.88 Pain Relevance 0.17
Leptin deficiency is responsible for immunosuppression and reduced
Negative_regulation (deficiency) of Leptin
10) Confidence 0.56 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 1.15 Pain Relevance 0.16
deficient in leptin, have reduced number of circulating CD4 T cell
Negative_regulation (deficient) of leptin in T cell
11) Confidence 0.56 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 1.05 Pain Relevance 0.11
Further, Sartorio et al. [46] used a combination of energy-restricted diets with a 5 d·wk-1 aerobic and anaerobic exercise program and reported an acute, significant reduction in leptin levels which closely mimicked changes in body mass.
Negative_regulation (reduction) of leptin in body
12) Confidence 0.55 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2693519 Disease Relevance 0.22 Pain Relevance 0
Volek and colleagues [3] suggested that significant decreases in leptin occur as part of an 8-week weight loss program, which similarly occurred in the present study.
Negative_regulation (decreases) of leptin associated with overnutrition
13) Confidence 0.55 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2693519 Disease Relevance 0.18 Pain Relevance 0
The attenuation of leptin sensitivity may result either from a downregulation of the leptin receptor or from impairments of the signal transduction process.
Negative_regulation (downregulation) of leptin
14) Confidence 0.55 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.90 Pain Relevance 0.04
As a defect in leptin action on body weight homeostasis has been reported for obese individuals despite high serum leptin concentrations, the current study was undertaken to determine whether chondrocytes from obese OA patients that are exposed to elevated leptin levels, exhibit an altered response to leptin.
Negative_regulation (defect) of leptin in body associated with body weight, obesity and osteoarthritis
15) Confidence 0.55 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.35 Pain Relevance 0.15
In rheumatoid arthritis (RA) patients it was reported that fasting leads to an improvement of clinical and biological measures of disease activity, which was associated with a marked decrease in serum leptin.
Negative_regulation (decrease) of serum leptin associated with rheumatoid arthritis and disease
16) Confidence 0.51 Published 2007 Journal Rheumatol. Int. Section Abstract Doc Link 17443329 Disease Relevance 1.28 Pain Relevance 0.47
Decreased serum leptin concentration in patients with chronic pancreatitis.
Negative_regulation (Decreased) of serum leptin associated with chronic pancreatitis
17) Confidence 0.51 Published 2007 Journal Pancreas Section Title Doc Link 17446840 Disease Relevance 0.29 Pain Relevance 0.24
CONCLUSION: The results presented in this article indicate that chronic pancreatitis in humans is associated with the decrease in serum leptin concentration.
Negative_regulation (decrease) of serum leptin
18) Confidence 0.51 Published 2007 Journal Pancreas Section Body Doc Link 17446840 Disease Relevance 0.07 Pain Relevance 0
Likewise, both enalapril and clonidine reduced heart sympathetic activity and blood pressure in another clinical trial, but failed to decrease serum leptin levels in normotensive obese and non-obese subjects after 7 days of treatment (Amador et al 2004).
Neg (failed) Negative_regulation (decrease) of serum leptin in sympathetic associated with obesity and clonidine
19) Confidence 0.50 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 1.27 Pain Relevance 0.21
The test P2-LEP was strongly inhibited at the 250-ms interstimulus interval ( P<0.01) and progressively recovered by the 2-s interval.
Negative_regulation (inhibited) of P2-LEP
20) Confidence 0.50 Published 2004 Journal Exp Brain Res Section Abstract Doc Link 15064893 Disease Relevance 0.16 Pain Relevance 0.08

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