INT62683

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 7.93
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HRAS) signal transduction (HRAS) Golgi apparatus (HRAS)
plasma membrane (HRAS) nucleus (HRAS) GTPase activity (HRAS)
Anatomy Link Frequency
cartilage 2
macrophages 1
articular cartilage 1
articular 1
joint 1
HRAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 201 99.64 Very High Very High Very High
corticosteroid 53 99.28 Very High Very High Very High
Inflammation 49 98.40 Very High Very High Very High
rheumatoid arthritis 8 97.24 Very High Very High Very High
cytokine 25 97.08 Very High Very High Very High
Inflammatory response 2 96.44 Very High Very High Very High
nud 1 95.08 Very High Very High Very High
antagonist 13 94.04 High High
cINOD 38 92.00 High High
Bile 1 89.24 High High
Disease Link Frequency Relevance Heat
Cancer 51 100.00 Very High Very High Very High
Osteoarthritis 180 99.64 Very High Very High Very High
Arthritis 19 99.00 Very High Very High Very High
Disease 29 98.80 Very High Very High Very High
INFLAMMATION 63 98.40 Very High Very High Very High
Rheumatoid Arthritis 8 97.24 Very High Very High Very High
Pancreatic Cancer 18 97.00 Very High Very High Very High
Colon Cancer 2 96.04 Very High Very High Very High
Adhesions 8 95.60 Very High Very High Very High
Dyspepsia 1 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, the relation between radiosensitization and the inhibition of oncogene products, such as, H-ras and c-erbB-1, has been the focus of attention (12, 13).
Negative_regulation (inhibition) of H-ras
1) Confidence 0.57 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526414 Disease Relevance 0.36 Pain Relevance 0
For example, numerous mutagenic events can occur throughout colorectal carcinogenesis, including loss of heterozygosity in tumor suppressor genes such as APC, MCC, DCC, and p53, as well as in oncogenes such as K-ras.
Negative_regulation (loss) of K-ras associated with cancer
2) Confidence 0.41 Published 1995 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 8672984 Disease Relevance 0.43 Pain Relevance 0.13
Does detection of K-ras mutations in pancreatic juice influence clinical decision making?
Negative_regulation (detection) of K-ras
3) Confidence 0.41 Published 2001 Journal Eur J Gastroenterol Hepatol Section Title Doc Link 11711767 Disease Relevance 0.49 Pain Relevance 0.17
A pancreatic carcinoma was discovered at an invasive stage in two patients, respectively at 7 and 17 months after disclosure of a K-ras mutation, versus none in patients without the mutation (p < 0.02).
Negative_regulation (disclosure) of K-ras
4) Confidence 0.41 Published 2001 Journal Am. J. Gastroenterol. Section Body Doc Link 11280537 Disease Relevance 0.12 Pain Relevance 0
Examination of pure pancreatic juice was positive for K-ras point mutation at codon 12 and negative for cytology.
Negative_regulation (positive) of K-ras
5) Confidence 0.41 Published 1998 Journal Am. J. Gastroenterol. Section Abstract Doc Link 9707068 Disease Relevance 0.43 Pain Relevance 0.05
CONCLUSIONS: These findings indicate that the pancreatic parenchyma in patients with chronic pancreatitis most frequently does not possess a K-ras mutation.


Neg (not) Negative_regulation (possess) of K-ras in parenchyma
6) Confidence 0.41 Published 1997 Journal Am. J. Surg. Section Body Doc Link 9324130 Disease Relevance 0.06 Pain Relevance 0
Detection of K-ras point mutations at codon 12 in pure pancreatic juice for the diagnosis of pancreatic cancer by PCR-RFLP analysis.
Negative_regulation (Detection) of K-ras associated with pancreatic cancer
7) Confidence 0.41 Published 1996 Journal Pancreas Section Title Doc Link 8927616 Disease Relevance 0.79 Pain Relevance 0.23
The H2RAs are currently the most widely used agents in prophylactic acid suppression; however, proton pump inhibitors (PPIs) have recently replaced H2RAs in the treatment of many acid-related conditions.
Negative_regulation (replaced) of H2RAs
8) Confidence 0.12 Published 2005 Journal Crit Care Section Abstract Doc Link PMC1065099 Disease Relevance 0.32 Pain Relevance 0.05
We conclude that HA in elderly patients undergoing major abdominal surgery can easily be replaced by a modern HES preparation.
Negative_regulation (replaced) of HA
9) Confidence 0.10 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16790652 Disease Relevance 0.23 Pain Relevance 0.16
This study was aimed to investigate the inhibitory mechanism of HA on lipopolysaccharide (LPS)-stimulated PGE(2) production in U937 human macrophages.
Spec (investigate) Negative_regulation (mechanism) of HA in macrophages
10) Confidence 0.09 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.60 Pain Relevance 0.37
The link between the superior acid-suppressive efficacy of the PPIs and a reduced risk of SRMD versus H2RAs has been demonstrated in only a limited number of clinical trials, and this evidence base needs to be extended.
Negative_regulation (reduced) of H2RAs in superior
11) Confidence 0.07 Published 2005 Journal Crit Care Section Body Doc Link PMC1065099 Disease Relevance 0.36 Pain Relevance 0.06
The effectiveness of HA in comparison to CS is also not very clear.
Negative_regulation (effectiveness) of HA associated with corticosteroid
12) Confidence 0.02 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998460 Disease Relevance 0.67 Pain Relevance 0.52
The authors concluded that given the lack of a superior effectiveness of HMW HA over LMW HA and the increased risk of local adverse events associated with the first, it is better to use intra-articular LMW HA in patients with OA of the knee in clinical research or practice.
Negative_regulation (effectiveness) of HA in knee associated with osteoarthritis
13) Confidence 0.02 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998460 Disease Relevance 0.59 Pain Relevance 0.20
The normal adult knee contains approximately 2 mL of synovial fluid, with a HA concentration of 2.5 to 4.0 mg/mL.13 In the arthritic joint, the concentration and molecular weight of HA are decreased by 33% to 50% because of dilution from inflammatory effusion, abnormal synoviocytes, and molecular fragmentation.14,15 These alterations lead to dramatically poorer viscous and elastic properties and, thus, distorted joint mechanics.
Negative_regulation (decreased) of HA in joint associated with inflammation and arthritis
14) Confidence 0.01 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004631 Disease Relevance 0.36 Pain Relevance 0.05
In both experimental and human osteoarthritis, the progressive reduction in the HA content of articular cartilage is believed to contribute to the apparent irreversibility of the disease process [49-51].
Negative_regulation (reduction) of HA in articular cartilage associated with disease and osteoarthritis
15) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.74 Pain Relevance 0.18
On the other hand, the enzyme activity may account for the progressive depletion of HA seen in osteoarthritis cartilage, a depletion that is believed to play an important role in the apparent irreversibility of this disease process.



Negative_regulation (depletion) of HA in cartilage associated with disease and osteoarthritis
16) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175024 Disease Relevance 0.19 Pain Relevance 0.10
Because the loss of HA from cartilage explants occurs in spite of an up-regulation in HA biosynthesis [52,53], a likely explanation is that HA strands are being degraded at an accelerated rate by a hyaluronidase active at near neutral pH.
Negative_regulation (loss) of HA in cartilage
17) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.59 Pain Relevance 0.16
In OA, both the concentration and molecular weight of intra-articular endogenous HA are decreased (6).
Negative_regulation (decreased) of HA in articular associated with osteoarthritis
18) Confidence 0.01 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2858840 Disease Relevance 0.60 Pain Relevance 0.22
However, as well as proto-oncoprotein levels, such as Fra-1, Fra-2, c-Jun, JunB, but not JunD, AA-induced increase of proENK mRNA was significantly reduced by the pretreatment with 10 microM of PD98059 (1.3-fold) or 10 microM of SB203580 (1.8-fold).
Negative_regulation (reduced) of proto-oncoprotein
19) Confidence 0.01 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10762717 Disease Relevance 0 Pain Relevance 0
The economic analysis suggests that there may be a case for prescribing H2RAs in all patients requiring NSAIDs.
Negative_regulation (prescribing) of H2RAs
20) Confidence 0.00 Published 2006 Journal Health Technol Assess Section Body Doc Link 17018227 Disease Relevance 0 Pain Relevance 0

General Comments

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