INT62684

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 66
Total Number 68
Disease Relevance 66.09
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
colon 2
vulva 1
fibroblasts 1
Mouse 1
thyroid 1
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 105 100.00 Very High Very High Very High
narcan 2 99.76 Very High Very High Very High
qutenza 15 99.38 Very High Very High Very High
Morphine 8 99.18 Very High Very High Very High
Inflammation 168 98.96 Very High Very High Very High
palliative 20 98.44 Very High Very High Very High
medulla 2 95.44 Very High Very High Very High
metalloproteinase 35 93.20 High High
aspirin 44 92.44 High High
withdrawal 5 90.20 High High
Disease Link Frequency Relevance Heat
Cancer 2628 100.00 Very High Very High Very High
Apoptosis 918 100.00 Very High Very High Very High
Aneuploidy 60 99.94 Very High Very High Very High
Malignant Neoplastic Disease 186 99.92 Very High Very High Very High
Colon Cancer 328 99.84 Very High Very High Very High
Breast Cancer 353 99.72 Very High Very High Very High
Tetraploidy 36 99.64 Very High Very High Very High
Pancreatic Cancer 204 99.60 Very High Very High Very High
Congenital Anomalies 196 99.38 Very High Very High Very High
Genital Human Papilloma Virus 107 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, we did not observe any correlation between melanocyte colonization and p53 overexpression, which is indicative of inactivating p53 mutations.
Negative_regulation (inactivating) of p53 in melanocyte
1) Confidence 0.58 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.89 Pain Relevance 0
For example, numerous mutagenic events can occur throughout colorectal carcinogenesis, including loss of heterozygosity in tumor suppressor genes such as APC, MCC, DCC, and p53, as well as in oncogenes such as K-ras.
Negative_regulation (loss) of p53 associated with cancer
2) Confidence 0.57 Published 1995 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 8672984 Disease Relevance 0.42 Pain Relevance 0.13
SB203580, a p38 mitogen-activated protein kinase inhibitor, and RNA inhibition of p53 inhibited the sulindac-induced apoptosis.
Negative_regulation (inhibition) of p53 associated with apoptosis
3) Confidence 0.47 Published 2007 Journal Apoptosis Section Abstract Doc Link 17136320 Disease Relevance 1.23 Pain Relevance 0.06
LOH could also be selected as the “second hit” for inactivating TP53 and CDKN2A.
Negative_regulation (inactivating) of TP53
4) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808095 Disease Relevance 0.91 Pain Relevance 0
We simultaneously measured DNA content abnormalities (tetraploidy and aneuploidy), inactivation of TP53 (mutation and LOH), and inactivation of CDKN2A (mutation, methylation, and LOH), all of which have been shown to be mechanistically related to neoplastic progression in BE [28,29,34,80–82].
Negative_regulation (inactivation) of TP53 associated with aneuploidy, tetraploidy and congenital anomalies
5) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808095 Disease Relevance 1.25 Pain Relevance 0
Induction of apoptosis is one of the mechanisms underlying the effects of chloroquine on suppressing glioma cell growth and viability. siRNA-mediated downregulation of p53 in wild-type but not mutant p53 glioblastoma cells substantially impaired chloroquine-induced apoptosis.
Negative_regulation (downregulation) of p53 associated with glioblastoma, apoptosis and glioma
6) Confidence 0.41 Published 2010 Journal Neuro-oncology Section Abstract Doc Link 20308316 Disease Relevance 1.20 Pain Relevance 0.08
Initially ONYX-015 was considered to efficiently replicate only in cells lacking functional p53 and to induce significant regression of human tumors developed in mice due to the tumor-specific viral replication (Bischoff et al 1996; Rogulski et al 2000).
Negative_regulation (lacking) of p53 associated with cancer
7) Confidence 0.41 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.83 Pain Relevance 0
About a half of human malignancies show loss of p53 functions, resulting in increased resistance to DNA-damaging agents (Shiraishi et al 2004).
Negative_regulation (loss) of p53
8) Confidence 0.41 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.44 Pain Relevance 0
Interestingly, capsaicin-sensitive leukemic cells were possessed of wild-type p53, resulting in the phosphorylation of p53 at the Ser-15 residue by the treatment of capsaicin.
Negative_regulation (possessed) of p53 associated with qutenza
9) Confidence 0.40 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14871840 Disease Relevance 0.65 Pain Relevance 1.11
Biallelic inactivation of the TP53 locus is found rarely in MPNST, which has led to the suggestion that hemizygous TP53 mutations may suffice for neurofibromas to progress and become MPNSTs.
Negative_regulation (inactivation) of TP53 associated with nerve sheath neoplasms and neurofibroma
10) Confidence 0.40 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2881068 Disease Relevance 1.98 Pain Relevance 0
Deletions and other mutations that result in loss of function of the TP53 tumor suppressor gene are some of the more common abnormalities found in MPNSTs.
Negative_regulation (loss) of TP53 associated with congenital anomalies and cancer
11) Confidence 0.40 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2881068 Disease Relevance 2.05 Pain Relevance 0
Combined immunohistochemical evaluation of HIF-1alpha, p53 and p21 protein expression at the pretreatment biopsy is a very useful and powerful indicator of sensitivity to CRT in human esophageal cancer.
Negative_regulation (evaluation) of p53 associated with esophageal cancer
12) Confidence 0.40 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170665 Disease Relevance 0.69 Pain Relevance 0.10
Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer.
Negative_regulation (evaluation) of p53 associated with esophageal cancer
13) Confidence 0.40 Published 2004 Journal Int. J. Cancer Section Title Doc Link 15170665 Disease Relevance 0.82 Pain Relevance 0
P53 is known to regulate Bax expression, with inactivation of p53 leading to reduced Bax protein levels [69,70].
Negative_regulation (inactivation) of p53
14) Confidence 0.40 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 1.31 Pain Relevance 0
The mutational inactivation of TP53 has been reported in progressive glioblastomas (5).
Negative_regulation (inactivation) of TP53 associated with glioblastoma
15) Confidence 0.38 Published 2010 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2991767 Disease Relevance 1.37 Pain Relevance 0.03
However, loss of function of p53 resulting from LOH may not correlate with protein overexpression.
Negative_regulation (loss) of p53
16) Confidence 0.37 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.68 Pain Relevance 0
A spectrum of chromosome aberrations was observed in transformed cells, with 40% showing loss of 17p (e.g. loss of one copy of p53).
Negative_regulation (loss) of p53 associated with chromosome aberrations
17) Confidence 0.36 Published 2010 Journal Radiat. Res. Section Abstract Doc Link 20681796 Disease Relevance 0.73 Pain Relevance 0.14
A number of miRNAs were discovered to be deregulated due to the loss of the p53 tumor suppressor in colon cancer cell lines.
Negative_regulation (loss) of p53 in colon associated with cancer and colon cancer
18) Confidence 0.35 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.71 Pain Relevance 0
In this study, we further investigated the clinical relevance of some of the miRNAs overexpressed due to the loss of p53 in colorectal cancer.
Negative_regulation (loss) of p53 associated with colon cancer
19) Confidence 0.35 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 1.16 Pain Relevance 0
Overexpression of these miRNAs may be due to the loss of p53 tumor suppressor function in tumors.


Negative_regulation (loss) of p53 associated with cancer
20) Confidence 0.35 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.91 Pain Relevance 0.05

General Comments

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