INT62689

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.66
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PPOX) small molecule metabolic process (PPOX) oxidoreductase activity (PPOX)
PPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 6 83.92 Quite High
alcohol 3 59.00 Quite High
Central nervous system 3 54.68 Quite High
addiction 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Variegate Porphyria 153 99.60 Very High Very High Very High
Acute Intermittent Porphyria 3 97.32 Very High Very High Very High
Porphyria 33 90.04 High High
Quadriplegia 3 88.36 High High
Hypertension 6 85.96 High High
Heart Rate Under Development 6 85.40 High High
Constipation 6 84.88 Quite High
Vomiting 6 84.32 Quite High
Abdominal Pain 6 83.92 Quite High
Sunburn 9 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The R59W mutation was present in 43 of 45 patients with VP from 26 of 27 South African families investigated, but not in 34 unaffected relatives or 9 unrelated British patients with PPO deficiency.
Negative_regulation (deficiency) of PPO associated with variegate porphyria
1) Confidence 0.58 Published 1996 Journal Nat. Genet. Section Abstract Doc Link 8673113 Disease Relevance 0.36 Pain Relevance 0
While earlier workers thought the distal haem biosynthetic enzyme ferrochelatase may be involved in the genesis of VP, it was shown in the early 1980's, and is now accepted, that VP is associated with decreased protoporphyrinogen oxidase activity (PPO) (E.C.1.3.3.4).
Negative_regulation (decreased) of PPO associated with variegate porphyria
2) Confidence 0.58 Published 1996 Journal Nat. Genet. Section Abstract Doc Link 8673113 Disease Relevance 1.20 Pain Relevance 0.08
While earlier workers thought the distal haem biosynthetic enzyme ferrochelatase may be involved in the genesis of VP, it was shown in the early 1980's, and is now accepted, that VP is associated with decreased protoporphyrinogen oxidase activity (PPO) (E.C.1.3.3.4).
Negative_regulation (decreased) of protoporphyrinogen oxidase associated with variegate porphyria
3) Confidence 0.58 Published 1996 Journal Nat. Genet. Section Abstract Doc Link 8673113 Disease Relevance 1.19 Pain Relevance 0.08
Activity measurements indicate that these mutations reduced about 50% PPOX activity and also that they co-segregate with this reduced activity value.
Negative_regulation (reduced) of PPOX
4) Confidence 0.39 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2467414 Disease Relevance 0 Pain Relevance 0
VP is an autosomal dominant disorder with incomplete penetrance, with heterozygous individuals exhibiting an approximately 50% reduced PPOX activity [1,2].
Negative_regulation (reduced) of PPOX associated with variegate porphyria
5) Confidence 0.39 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2467414 Disease Relevance 1.30 Pain Relevance 0.11
A partial deficiency in Protoporphyrinogen oxidase (PPOX) produces the mixed disorder Variegate Porphyria (VP), the second acute porphyria more frequent in Argentina.
Negative_regulation (deficiency) of PPOX associated with variegate porphyria and acute intermittent porphyria
6) Confidence 0.29 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2467414 Disease Relevance 0.62 Pain Relevance 0
In contrast to laccase and bilirubin oxidase, PPO could efficiently operate at pH 7 and was not inhibited by products present in physiological fluids.
Negative_regulation (inhibited) of PPO
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864295 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox