INT62691

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Context Info
Confidence 0.40
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 3.50
Pain Relevance 6.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
neuronal 1
neurons 1
striatum 1
Neuro-2a 1
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 77 100.00 Very High Very High Very High
substance P 14 100.00 Very High Very High Very High
Neuropeptide 9 100.00 Very High Very High Very High
Glutamate receptor 3 100.00 Very High Very High Very High
cocaine 12 99.56 Very High Very High Very High
Hippocampus 1 99.56 Very High Very High Very High
cerebral cortex 2 98.92 Very High Very High Very High
Dopamine 26 98.72 Very High Very High Very High
alcohol 5 98.46 Very High Very High Very High
Glutamate 5 91.76 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 4 99.24 Very High Very High Very High
Targeted Disruption 34 98.80 Very High Very High Very High
Disease 8 97.00 Very High Very High Very High
Aids-related Complex 1 94.00 High High
Injury 3 90.80 High High
Middle Cerebral Artery Infarction 7 90.12 High High
Drug Dependence 1 80.00 Quite High
Cv Unclassified Under Development 1 76.88 Quite High
Anxiety Disorder 6 75.00 Quite High
Stroke 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged alcohol drinking can perturb aspects of this system, including a loss of control of Met-enkephalin levels at the transcriptional and translational levels, and impaired release of Met-enkephalin from tissue sources.
Transcription (transcriptional) of Met-enkephalin associated with enkephalin and alcohol
1) Confidence 0.40 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.14 Pain Relevance 0.67
We examined the relationships among concentrations of Met-enkephalin, preproenkephalin (PPE) mRNA, and PTS-1 activity in mice exposed to ethanol.
Transcription (concentrations) of Met-enkephalin associated with enkephalin
2) Confidence 0.35 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9160250 Disease Relevance 0 Pain Relevance 0.95
Mouse neuroblastoma Neuro-2a cells were examined for the expression of pro-enkephalin mRNA, protein, and Met-enkephalin ([Met]-Enk) peptide.
Spec (examined) Transcription (expression) of pro-enkephalin in Neuro-2a associated with neuroblastoma and enkephalin
3) Confidence 0.29 Published 1995 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8674823 Disease Relevance 0.17 Pain Relevance 0.51
Reverse transcriptase/polymerase chain reaction (RT/PCR) and in situ hybridization demonstrated the presence of pro-enkephalin mRNA in these cells.
Transcription (presence) of pro-enkephalin associated with enkephalin
4) Confidence 0.25 Published 1995 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8674823 Disease Relevance 0.17 Pain Relevance 0.60
Both transgenic and knock-in mice, however, showed a marked decrease in the level of expression of enkephalin mRNA in striatal neurons without significant decreases in mRNAs encoding substance P, GAD65, or GAD67.
Transcription (expression) of enkephalin in neurons associated with targeted disruption, enkephalin and substance p
5) Confidence 0.16 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10739639 Disease Relevance 0.81 Pain Relevance 0.60
The data indicate that decreased expression of enkephalin mRNA may be an early sign of neuronal dysfunction due to the Huntington's disease mutation.
Transcription (expression) of enkephalin in neuronal associated with enkephalin and disease
6) Confidence 0.16 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10739639 Disease Relevance 0.85 Pain Relevance 0.56
The expression of enkephalin mRNA in the striatum is increased in the mutant mice, but not that of dynorphin and substance P.
Transcription (expression) of enkephalin in striatum
7) Confidence 0.11 Published 1996 Journal Genes Cells Section Body Doc Link 9140068 Disease Relevance 0 Pain Relevance 0
In contrast, mutant mice showed altered response in mRNA levels of N-methyl-D-aspartate, GLUR5 and GLUR6 glutamate receptor subunits as well as of enkephalin following cocaine administration.
Transcription (levels) of enkephalin associated with glutamate receptor, enkephalin and cocaine
8) Confidence 0.09 Published 2006 Journal Neuroscience Section Abstract Doc Link 16326019 Disease Relevance 0.39 Pain Relevance 0.72
Striatal expression of substance P and enkephalin mRNAs was reduced by about 50% and 30%, respectively, whereas the expression of GAD67 and GAD65 mRNAs was slightly increased and unaltered, respectively.
Transcription (expression) of enkephalin associated with enkephalin and substance p
9) Confidence 0.07 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11432985 Disease Relevance 0.09 Pain Relevance 0.64
The present study assessed alterations in mesolimbic enkephalin (ENK) mRNA levels after predator [2,5-dihydro-2,4,5-trimethylethiazoline (TMT)] and non-predator (butyric acid) odor encounter and/or light-dark (LD) testing in CD-1 mice immediately, 24, 48 and 168 h after the initial odor encounter and/or LD testing.
Transcription (levels) of enkephalin associated with enkephalin
10) Confidence 0.05 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525282 Disease Relevance 0.07 Pain Relevance 0.54
Prominent among these were transcripts encoding the PACAP-regulated gene Ier3, and the neuropeptides enkephalin, substance P (tachykinin 1), and neurotensin.
Transcription (transcripts) of enkephalin associated with neuropeptide, enkephalin and substance p
11) Confidence 0.05 Published 2006 Journal Regul. Pept. Section Abstract Doc Link 17027094 Disease Relevance 0.81 Pain Relevance 0.30
Moreover, the loss of DA innervation caused by 6-hydroxydopamine (6-OHDA) increased the expression of mRNAs encoding the D2R and enkephalin selectively in striatopallidal MSNs, whereas mRNAs encoding the D1R and substance P were only decreased in striatonigral MSNs (Gerfen et al., 1990).
Transcription (expression) of enkephalin associated with dopamine, enkephalin and substance p
12) Confidence 0.03 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.58

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