INT62710

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2011
Negated 3
Speculated 1
Reported most in Abstract
Documents 160
Total Number 161
Disease Relevance 88.27
Pain Relevance 26.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (HGF) extracellular space (HGF) extracellular region (HGF)
cell morphogenesis (HGF)
Anatomy Link Frequency
HGF 62
hepatocyte 26
fibroblasts 8
joints 3
cardiomyocytes 2
HGF (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 732 100.00 Very High Very High Very High
Inflammation 508 100.00 Very High Very High Very High
cytokine 469 100.00 Very High Very High Very High
Pain 266 100.00 Very High Very High Very High
chemokine 159 100.00 Very High Very High Very High
Angina 59 100.00 Very High Very High Very High
cINOD 124 99.92 Very High Very High Very High
COX2 34 99.92 Very High Very High Very High
Arthritis 97 99.62 Very High Very High Very High
Inflammatory response 32 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 736 100.00 Very High Very High Very High
INFLAMMATION 619 100.00 Very High Very High Very High
Pain 270 100.00 Very High Very High Very High
Cv General 3 Under Development 74 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 25 100.00 Very High Very High Very High
Hiv-narrow Range Search Term 1792 99.98 Very High Very High Very High
Stomach Cancer 92 99.96 Very High Very High Very High
Chronic Hepatitis 63 99.84 Very High Very High Very High
Chordoma 30 99.80 Very High Very High Very High
Pressure And Volume Under Development 47 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The density of endoneurial capillaries, disclosing marked reduction in diabetic rats, was also reversed significantly by repeated gene transfer of HGF; however, no considerable differences were observed morphometrically in either myelinated or unmyelinated axons.
Gene_expression (transfer) of HGF in HGF associated with diabetes mellitus and unmyelinated
1) Confidence 0.78 Published 2005 Journal Diabetes Section Abstract Doc Link 15734864 Disease Relevance 0.73 Pain Relevance 0.30
All these changes were significantly reversed by repeated gene transfer of HGF.
Gene_expression (transfer) of HGF in HGF
2) Confidence 0.78 Published 2005 Journal Diabetes Section Abstract Doc Link 15734864 Disease Relevance 0.80 Pain Relevance 0.32
These results suggest that nonviral HVJ liposome-mediated gene transfer of human HGF has potential for the safe effective treatment of diabetic sensorimotor neuropathy.
Gene_expression (transfer) of HGF in HGF associated with diabetes mellitus and neuropathic pain
3) Confidence 0.78 Published 2005 Journal Diabetes Section Abstract Doc Link 15734864 Disease Relevance 0.81 Pain Relevance 0.26
Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats.
Gene_expression (transfer) of hepatocyte growth factor in hepatocyte associated with diabetic neuropathy
4) Confidence 0.78 Published 2005 Journal Diabetes Section Title Doc Link 15734864 Disease Relevance 0.81 Pain Relevance 0.29
Also other drugs (ACE-inhibitors) may take part in regulation of HGF synthesis.
Gene_expression (synthesis) of HGF in HGF
5) Confidence 0.78 Published 2004 Journal Pol. Merkur. Lekarski Section Abstract Doc Link 15559622 Disease Relevance 0.44 Pain Relevance 0.15
We hypothesized that dexamethasone (DEX) may inhibit PG production and HGF expression, thus inhibiting HGF-induced gastric epithelial restitution.
Gene_expression (expression) of HGF in HGF associated with dexamethasone
6) Confidence 0.77 Published 2003 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 12925150 Disease Relevance 0.18 Pain Relevance 0.18
HGF expression is induced by PGs in gastric fibroblasts.
Gene_expression (expression) of HGF in fibroblasts
7) Confidence 0.77 Published 2003 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 12925150 Disease Relevance 0.19 Pain Relevance 0.18
Further, NSAIDs may delay the healing of gastric mucosal ulcer, in part through suppression of HGF expression via inhibition of endogenous PG production.
Gene_expression (expression) of HGF in HGF associated with ulcers and cinod
8) Confidence 0.77 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.31 Pain Relevance 0.34
IND significantly reduced both basal and IL-1 beta-induced PGE2 release and HGF production.
Gene_expression (production) of HGF in HGF
9) Confidence 0.77 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.23 Pain Relevance 0.36
In this study, we investigated the effects of cytokines, growth factors, and IND on production of PG and HGF, and induction of COX using cultured human gastric fibroblasts.
Gene_expression (production) of HGF in HGF associated with cytokine
10) Confidence 0.77 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.26 Pain Relevance 0.37
Exogenous PGs significantly increased HGF production in a dose-dependent manner.
Gene_expression (production) of HGF in HGF
11) Confidence 0.77 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.25 Pain Relevance 0.36
Among various potential stimulants tested, interleukin-1 beta (IL-1 beta) dramatically increased PGE2 production and significantly stimulated HGF production.
Gene_expression (production) of HGF in HGF
12) Confidence 0.77 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.24 Pain Relevance 0.36
Nonsteroidal anti-inflammatory drugs may delay the repair of gastric mucosa by suppressing prostaglandin-mediated increase of hepatocyte growth factor production.
Gene_expression (production) of hepatocyte growth factor in hepatocyte associated with inflammation and cinod
13) Confidence 0.77 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9571196 Disease Relevance 0.28 Pain Relevance 0.48
NSAIDs, if added early during fibroblast aggregation, inhibited HGF/SF production effectively but had no effect at later stages of cell aggregation.
Gene_expression (production) of HGF in HGF associated with cinod
14) Confidence 0.75 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16267016 Disease Relevance 0.66 Pain Relevance 0.25
Nonsteroidal anti-inflammatory drugs may prevent colon cancer through suppression of hepatocyte growth factor expression.
Gene_expression (expression) of hepatocyte growth factor in hepatocyte associated with inflammation, colon cancer and cinod
15) Confidence 0.75 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10082276 Disease Relevance 0.53 Pain Relevance 0.38
Nonsteroidal anti-inflammatory drugs may suppress colon carcinogenesis, in part, through the suppression of hepatocyte growth factor expression by inhibiting endogenous prostaglandin production.
Gene_expression (expression) of hepatocyte growth factor in hepatocyte associated with inflammation and cinod
16) Confidence 0.75 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082276 Disease Relevance 0.32 Pain Relevance 0.17
These results suggest that prostaglandin is a factor for the production of hepatocyte growth factor by human colonic fibroblasts.
Gene_expression (production) of hepatocyte growth factor in fibroblasts
17) Confidence 0.75 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082276 Disease Relevance 0.37 Pain Relevance 0.23
Growth factors such as hepatocyte growth factor, which are produced by fibroblasts, have been shown to be important in carcinogenesis and the progression of various human cancers.
Gene_expression (produced) of hepatocyte growth factor in hepatocyte associated with cancer
18) Confidence 0.75 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082276 Disease Relevance 0.42 Pain Relevance 0.26
In the present study, we tested the hypothesis that nonsteroidal anti-inflammatory drugs inhibit hepatocyte growth factor expression through an endogenous prostaglandin-mediated pathway in cultured human colonic fibroblasts.
Gene_expression (expression) of hepatocyte growth factor in fibroblasts associated with inflammation and cinod
19) Confidence 0.75 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082276 Disease Relevance 0.49 Pain Relevance 0.26
Cholera toxin and 8-bromo cAMP also stimulated hepatocyte growth factor production.
Gene_expression (production) of hepatocyte growth factor in hepatocyte associated with vibrio infection
20) Confidence 0.75 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082276 Disease Relevance 0.46 Pain Relevance 0.21

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