INT62712

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 7.21
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (HGF) extracellular space (HGF) extracellular region (HGF)
cell morphogenesis (HGF)
Anatomy Link Frequency
HGF 7
hepatocyte 1
bone marrow 1
fibroblasts 1
HGF (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 99.56 Very High Very High Very High
Pain 57 98.64 Very High Very High Very High
backache 120 96.60 Very High Very High Very High
depression 20 94.76 High High
drug abuse 1 89.52 High High
Percutaneous transluminal coronary angioplasty 33 85.56 High High
Pain score 2 82.72 Quite High
Angina 6 81.00 Quite High
Inflammatory response 2 75.52 Quite High
melanocortin 1 receptor 1 72.52 Quite High
Disease Link Frequency Relevance Heat
Ulcers 11 100.00 Very High Very High Very High
Chronic Disease 12 99.84 Very High Very High Very High
Lung Cancer 136 99.32 Very High Very High Very High
Pain 61 98.64 Very High Very High Very High
Fatigue 90 98.44 Very High Very High Very High
Low Back Pain 122 96.60 Very High Very High Very High
Somatoform Disorder 1 96.52 Very High Very High Very High
Anxiety Disorder 10 95.52 Very High Very High Very High
Depression 30 94.76 High High
Disease 37 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: DEX inhibits restitution via HGF depletion, and rebamipide reverses the inhibited restitution by HGF induction.


Negative_regulation (depletion) of HGF in HGF
1) Confidence 0.58 Published 2003 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 12925150 Disease Relevance 0 Pain Relevance 0
Accordingly, it inhibited PGE2 and HGF release. 2.
Negative_regulation (inhibited) of HGF in HGF
2) Confidence 0.42 Published 2003 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 12925150 Disease Relevance 0 Pain Relevance 0
DEX inhibited HGF mRNA and COX-2 mRNA.
Negative_regulation (inhibited) of HGF in HGF
3) Confidence 0.42 Published 2003 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 12925150 Disease Relevance 0 Pain Relevance 0
Serum HGF levels decreased to nearly normal by day 21 (0.22+/-0.01 ng/ml).
Negative_regulation (decreased) of HGF in HGF
4) Confidence 0.41 Published 2002 Journal Circ. J. Section Abstract Doc Link 11922273 Disease Relevance 0.67 Pain Relevance 0.27
A similar result was also obtained by the addition of blocking anti-alphaHGF antibody in the chemoattractant chamber.
Negative_regulation (blocking) of HGF
5) Confidence 0.41 Published 2003 Journal Oncol. Res. Section Abstract Doc Link 14760865 Disease Relevance 0.23 Pain Relevance 0.07
The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblasts.
Negative_regulation (inhibitor) of HGF in fibroblasts associated with ulcers and cinod
6) Confidence 0.35 Published 2000 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 10807402 Disease Relevance 0.48 Pain Relevance 0.10
These agents also inhibited H. pylori-induced HGF release.
Negative_regulation (inhibited) of HGF in HGF
7) Confidence 0.34 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10807402 Disease Relevance 0.19 Pain Relevance 0
CONCLUSIONS: Gastric mucosal HGF levels were elevated in H. pylori gastritis and reduced by its eradication.
Negative_regulation (reduced) of HGF in HGF
8) Confidence 0.30 Published 1996 Journal Am. J. Gastroenterol. Section Body Doc Link 8678004 Disease Relevance 0.20 Pain Relevance 0
Based on a significant decrease of VEGF and hepatocyte growth factor levels, and a significant increase in TSP-1 thrombospondin-1 concentrations in the bone marrow plasma of patients who achieved complete or very good partial response versus those who had partial or no response, they concluded that a reduction in the rate of angiogenesis had occurred.
Negative_regulation (decrease) of hepatocyte growth factor in bone marrow
9) Confidence 0.18 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 0.96 Pain Relevance 0.03
Indomethacin significantly reduced interleukin-1beta-induced prostaglandin E2 release and hepatocyte growth factor production.
Negative_regulation (reduced) of hepatocyte growth factor in hepatocyte
10) Confidence 0.18 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082276 Disease Relevance 0.43 Pain Relevance 0.22
All of the SF-36 dimensions were remarkably impaired by chronic diseases.
Negative_regulation (impaired) of SF-36 associated with chronic disease
11) Confidence 0.13 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2527564 Disease Relevance 0.62 Pain Relevance 0
As shown, as self-rated health declines, there is a monotonic decrease in mean SF6D_SF36 utility scores in both sexes in both time periods (1995 and 2000).Fig. 3a Mean SF6D_SF36 scores by health status in 1995. b Mean SF6D_SF36 scores by health status in 2000.
Negative_regulation (decrease) of SF6D_SF36
12) Confidence 0.11 Published 2010 Journal Qual Life Res Section Body Doc Link PMC2963736 Disease Relevance 0 Pain Relevance 0
The results of the MPQ-SF are presented in table 3.
Negative_regulation (presented) of MPQ-SF
13) Confidence 0.08 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2967511 Disease Relevance 0.78 Pain Relevance 0.78
To reduce the number of missing scores in the SF-6D, we imputed missing items in the SF-36 from the SF-36 domain scores.
Negative_regulation (reduce) of SF-6D
14) Confidence 0.04 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1475841 Disease Relevance 0 Pain Relevance 0
After imputation of the missing SF-36 items from SF-36 domain scores, the percentage of missing scores in the SF-6D due to missing items was reduced by half, both at baseline and post-intervention (Table 1).
Negative_regulation (reduced) of SF-6D
15) Confidence 0.04 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1475841 Disease Relevance 0 Pain Relevance 0
Recently, some studies were done that compared the EQ-5D and the SF-6D, as in our study [21,24-29].
Negative_regulation (compared) of SF-6D
16) Confidence 0.04 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1475841 Disease Relevance 0.16 Pain Relevance 0
We used that technique to reduce the number of missing scores in the SF-6D; imputing a value for missing items in a SF-36 domain using the mean value for that domain.
Negative_regulation (reduce) of SF-6D
17) Confidence 0.04 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1475841 Disease Relevance 0 Pain Relevance 0
Subjects also completed the SF-36 [11], the MFI [13] and the Symptom Inventory [14] before arriving at the hospital, at which time the study manager, who resolved missing responses, reviewed them.
Negative_regulation (completed) of SF-36
18) Confidence 0.04 Published 2005 Journal BMC Med Section Body Doc Link PMC1334212 Disease Relevance 1.24 Pain Relevance 0.20
Vogelzang et al. recently reviewed new agents that under evaluation for the treatment of MM, including EGFR, PDGFR, VEGF and HGF inhibitors, inhibitors of mTOR, a downstream molecule of the PI3K/AKT pathway, and inhibitors of the proteasome/ubiquitin pathway (Vogelzang, 2005).
Negative_regulation (inhibitors) of HGF in HGF associated with lung cancer
19) Confidence 0.03 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.24 Pain Relevance 0

General Comments

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