INT62725

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Title
Documents 6
Total Number 6
Disease Relevance 2.98
Pain Relevance 5.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIN2D) plasma membrane (GRIN2D)
GRIN2D (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 15 100.00 Very High Very High Very High
Pain 14 100.00 Very High Very High Very High
nMDA receptor 13 100.00 Very High Very High Very High
nociceptor 2 100.00 Very High Very High Very High
antagonist 4 99.96 Very High Very High Very High
Dextromethorphan 17 99.52 Very High Very High Very High
Opioid 9 99.52 Very High Very High Very High
ketamine 12 99.48 Very High Very High Very High
Pain management 1 99.48 Very High Very High Very High
addiction 3 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 14 99.80 Very High Very High Very High
Opiate Addiction 4 99.52 Very High Very High Very High
Hyperalgesia 5 98.48 Very High Very High Very High
Fibromyalgia 13 97.04 Very High Very High Very High
Nociception 4 96.44 Very High Very High Very High
Hypersensitivity 1 91.56 High High
Burns 4 88.16 High High
Injury 4 87.96 High High
Stroke 1 72.20 Quite High
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of systemic N-methyl-D-aspartate receptor antagonist (ketamine) on primary and secondary hyperalgesia in humans.
Regulation (Effect) of N-methyl-D-aspartate receptor associated with hyperalgesia, ketamine, antagonist and nmda receptor
1) Confidence 0.45 Published 1996 Journal Br J Anaesth Section Title Doc Link 8679358 Disease Relevance 0.77 Pain Relevance 0.91
Effect of systemic N-methyl-D-aspartate receptor antagonist (dextromethorphan) on primary and secondary hyperalgesia in humans.
Regulation (Effect) of N-methyl-D-aspartate receptor associated with hyperalgesia, antagonist, nmda receptor and dextromethorphan
2) Confidence 0.44 Published 1997 Journal Br J Anaesth Section Title Doc Link 9422898 Disease Relevance 0.62 Pain Relevance 1.03
Effects of the N-methyl-D-aspartate receptor antagonist dextromethorphan on temporal summation of pain are similar in fibromyalgia patients and normal control subjects.
Regulation (Effects) of N-methyl-D-aspartate receptor associated with pain, antagonist, nmda receptor, dextromethorphan and fibrositis
3) Confidence 0.38 Published 2005 Journal J Pain Section Title Doc Link 15890634 Disease Relevance 0.75 Pain Relevance 1.35
As a conclusion, our data indicate that the transcriptional level of the NR2D subunit of NMDA receptor is not regulated by chronic opioid addiction.
Neg (not) Regulation (regulated) of NR2D subunit associated with addiction, nmda receptor and opioid
4) Confidence 0.22 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20153313 Disease Relevance 0.33 Pain Relevance 1.25
Targeting the N-methyl-D-aspartate receptor for chronic pain management.
Regulation (Targeting) of N-methyl-D-aspartate receptor associated with pain, nmda receptor and pain management
5) Confidence 0.21 Published 2000 Journal J Pain Symptom Manage Section Title Doc Link 11068158 Disease Relevance 0.43 Pain Relevance 0.87
The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications.
Regulation (regulation) of N-methyl-D-aspartate receptor subunit associated with pain and nmda receptor
6) Confidence 0.18 Published 2003 Journal Pharmacol. Ther. Section Title Doc Link 12493535 Disease Relevance 0.07 Pain Relevance 0.27

General Comments

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