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Context Info
Confidence 0.18
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.04
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc2r) plasma membrane (Mc2r) signal transducer activity (Mc2r)
Anatomy Link Frequency
anterior pituitary 2
plasma 1
melanocyte 1
T cells 1
Mc2r (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 13 98.90 Very High Very High Very High
adenocard 2 98.88 Very High Very High Very High
local anesthetic 6 95.96 Very High Very High Very High
Regional anesthesia 1 92.64 High High
anesthesia 1 90.08 High High
corticosteroid 3 75.00 Quite High
Pain 3 72.40 Quite High
Inflammation 11 66.04 Quite High
Arthritis 1 52.16 Quite High
Neuropeptide 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 46 92.52 High High
Sleep Disorders 1 91.56 High High
Targeted Disruption 7 91.44 High High
Stress 5 88.96 High High
Hypersensitivity 16 84.08 Quite High
Pain 2 72.40 Quite High
INFLAMMATION 12 66.04 Quite High
Uveitis 1 53.12 Quite High
Arthritis 1 52.16 Quite High
Multiple Sclerosis 1 49.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of Met-enkephalin (MENK) on several immune functions, corticosterone (CS) and adrenocorticotropin (ACTH) levels in the plasma was studied in adrenalectomized (ADX) and sham-adrenalectomized (SADX) mice.
Gene_expression (levels) of adrenocorticotropin in plasma associated with enkephalin
1) Confidence 0.18 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1325954 Disease Relevance 0 Pain Relevance 0.46
Corticotropin-releasing hormone (CRH) mainly regulates the synthesis and secretion of adrenocorticotropin (ACTH) in the anterior pituitary (AP).
Gene_expression (synthesis) of adrenocorticotropin in anterior pituitary
2) Confidence 0.15 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15331153 Disease Relevance 0.14 Pain Relevance 0.07
We hypothesized that local anesthetics may directly affect proopiomelanocortin gene expression and can modulate production of adrenocorticotropic hormone and beta-endorphin.
Gene_expression (production) of adrenocorticotropic hormone
3) Confidence 0.05 Published 2007 Journal Reg Anesth Pain Med Section Abstract Doc Link 17196494 Disease Relevance 0.09 Pain Relevance 0.30
The relevance of NO in neuroendocrine signalling has been investigated by analysis of cellular expression of pro-opiomelanocortin (POMC) and the POMC-derived peptides beta-endorphin, alpha-melanocyte stimulating hormone and adrenocorticotropin.
Gene_expression (expression) of adrenocorticotropin in melanocyte
4) Confidence 0.05 Published 2001 Journal Acta Histochem. Section Abstract Doc Link 11700945 Disease Relevance 0.23 Pain Relevance 0
BACKGROUND AND OBJECTIVES: Corticotropin-releasing hormone (CRH) induces gene expression of proopiomelanocortin, a precursor protein of adrenocorticotropic hormone and beta-endorphin, by elevating intracellular cyclic adenosine 3',5'-monophosphate (cyclic AMP) level in anterior pituitary cells and immune cells.
Gene_expression (expression) of adrenocorticotropic hormone in anterior pituitary associated with adenocard
5) Confidence 0.04 Published 2007 Journal Reg Anesth Pain Med Section Abstract Doc Link 17196494 Disease Relevance 0.08 Pain Relevance 0.27
Whereas MC-2R, MC-3R, MC-4R and MC-5R are not expressed by T cells, MC-1R was found in naive murine CD8+ T cells and was up-regulated upon stimulation with ?
Neg (not) Gene_expression (expressed) of MC-2R in T cells
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.40 Pain Relevance 0.08
It is not known whether benzodiazepines affect expression of proopiomelanocortin, precursor protein of adrenocorticotropic hormone and related peptides.
Gene_expression (expression) of adrenocorticotropic hormone
7) Confidence 0.03 Published 2003 Journal Anesthesiology Section Abstract Doc Link 12717139 Disease Relevance 0.09 Pain Relevance 0.18

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