INT6277

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2011
Negated 4
Speculated 2
Reported most in Abstract
Documents 76
Total Number 78
Disease Relevance 21.45
Pain Relevance 31.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
plasma 15
caudate-putamen 10
pituitary 10
tail 4
hypothalamus 4
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 184 100.00 Very High Very High Very High
medulla 180 100.00 Very High Very High Very High
Morphine 89 100.00 Very High Very High Very High
Opioid 70 100.00 Very High Very High Very High
Enkephalin 63 100.00 Very High Very High Very High
Nucleus accumbens 38 100.00 Very High Very High Very High
opioid receptor 24 100.00 Very High Very High Very High
analgesia 15 100.00 Very High Very High Very High
antinociception 11 100.00 Very High Very High Very High
Substantia nigra 11 99.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 549 99.98 Very High Very High Very High
Spontaneous Abortion 6 99.98 Very High Very High Very High
Hyperplasia 18 99.90 Very High Very High Very High
Cancer 268 99.84 Very High Very High Very High
Anorexia 84 99.84 Very High Very High Very High
Inflammatory Pain 6 99.84 Very High Very High Very High
Pain 31 99.82 Very High Very High Very High
Acth-secreting Pituitary Adenoma 7 99.76 Very High Very High Very High
Disease 30 99.72 Very High Very High Very High
Viral Infection 9 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Meanwhile, naloxone as well as muscimol and baclofen significantly attenuated the increases of the POMC gene expression induced by a single morphine administration.
Positive_regulation (induced) of Gene_expression (expression) of POMC gene associated with narcan and morphine
1) Confidence 0.70 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.96
Meanwhile, naloxone as well as muscimol and baclofen significantly attenuated the increases of the POMC gene expression induced by a single morphine administration.
Positive_regulation (increases) of Gene_expression (expression) of POMC gene associated with narcan and morphine
2) Confidence 0.70 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.96
In that, GABAergic neurotransmission appear to be involved in the regulation of the hypothalamic POMC gene expression induced by supraspinal morphine administration.
Positive_regulation (induced) of Gene_expression (expression) of POMC gene associated with gabaergic and morphine
3) Confidence 0.70 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.76
A single morphine administration significantly increased the hypothalamic POMC gene and beta-endorphin expression at 2h after application in dose-dependent fashion; however, repeated morphine administration had no effect on the hypothalamic POMC gene and beta-endorphin expression.
Positive_regulation (increased) of Gene_expression (expression) of beta-endorphin associated with morphine
4) Confidence 0.70 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.55
Using an enzyme immunoassay and immunohistochemistry for beta-endorphin, we showed that in vitro stimulation of T lymphocytes induced the synthesis and release of beta-endorphin and that transfer of T cells into SCID mice increased the expression of beta-endorphin in the enteric nervous system.
Positive_regulation (induced) of Gene_expression (synthesis) of beta-endorphin in enteric nervous system
5) Confidence 0.68 Published 2006 Journal Gastroenterology Section Body Doc Link 16697736 Disease Relevance 0.08 Pain Relevance 0
Using an enzyme immunoassay and immunohistochemistry for beta-endorphin, we showed that in vitro stimulation of T lymphocytes induced the synthesis and release of beta-endorphin and that transfer of T cells into SCID mice increased the expression of beta-endorphin in the enteric nervous system.
Positive_regulation (increased) of Gene_expression (expression) of beta-endorphin in enteric nervous system
6) Confidence 0.68 Published 2006 Journal Gastroenterology Section Body Doc Link 16697736 Disease Relevance 0.07 Pain Relevance 0
In vitro, T helper (Th) type 1 and type 2 cytokine stimulation of CD4+ T cells or isolation of T cells from in vivo Th-polarized mice did not increase T cell release of beta-endorphin or the induction of beta-endorphin expression in the myenteric plexus.
Positive_regulation (induction) of Gene_expression (expression) of beta-endorphin in T cells associated with cytokine
7) Confidence 0.68 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16959949 Disease Relevance 0.28 Pain Relevance 0.71
Induction of neuropathy resulted in decrease of lumbar pro-opiomelanocortin (POMC) gene expression in wild-type mice, but increase of POMC expression in CCK(2) (-/-) mice.
Positive_regulation (increase) of Gene_expression (expression) of POMC associated with neuropathic pain and cholecystokinin
8) Confidence 0.67 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15355324 Disease Relevance 0.86 Pain Relevance 1.71
In conclusion, POMC mRNA expression in the arcuate nucleus of the hypothalamus was increased by inflammatory pain stimuli, in which pERK1/2, pCaMK-IIalpha and NFkappaB may play an important role in the expression of the hypothalamic POMC gene and beta-endorphin expression.
Positive_regulation (increased) of Gene_expression (expression) of POMC mRNA in arcuate nucleus associated with ipn
9) Confidence 0.66 Published 2008 Journal Neuroscience Section Abstract Doc Link 18329177 Disease Relevance 0.17 Pain Relevance 0.20
In addition, formalin-induced POMC mRNA expression was significantly reduced by 10 min, pretreatment with i.c.v.
Positive_regulation (induced) of Gene_expression (expression) of POMC mRNA
10) Confidence 0.66 Published 2008 Journal Neuroscience Section Abstract Doc Link 18329177 Disease Relevance 0.07 Pain Relevance 0.24
Although the exact mechanism of high plasma ACTH level in this case was unknown, these findings suggest that any substance secreted from primary adrenal nodular hyperplasia adrenal nodular hyperplasia may stimulate pituitary ACTH production.
Spec (may) Positive_regulation (stimulate) of Gene_expression (production) of ACTH in plasma associated with hyperplasia
11) Confidence 0.61 Published 1994 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 7851619 Disease Relevance 0.67 Pain Relevance 0
Spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (TH) mRNA levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (PENK) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus.
Positive_regulation (increased) of Gene_expression (expression) of pro-opiomelanocortin in caudate-putamen associated with nucleus accumbens, ventral tegmentum, substantia nigra, cannabinoid and withdrawal
12) Confidence 0.57 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641731 Disease Relevance 0.23 Pain Relevance 0.82
Food restriction reduces hypothalamic pomc mRNA expression [49], whereas hypothalamic pomc mRNA expression is increased in overfed rats [50].
Positive_regulation (increased) of Gene_expression (expression) of pomc mRNA associated with eating disorder
13) Confidence 0.56 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.15 Pain Relevance 0.08
A single morphine administration significantly increased the hypothalamic POMC gene and beta-endorphin expression at 2h after application in dose-dependent fashion; however, repeated morphine administration had no effect on the hypothalamic POMC gene and beta-endorphin expression.
Positive_regulation (increased) of Gene_expression (expression) of POMC gene associated with morphine
14) Confidence 0.50 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.55
The data support the hypothesis that beta-endorphin, morphine and DPDPE produce antinociception by stimulating specific epsilon, mu- and delta-opioid receptors, respectively.
Positive_regulation (stimulating) of Gene_expression (produce) of beta-endorphin associated with antinociception, delta opioid receptors and morphine
15) Confidence 0.50 Published 1990 Journal Life Sci. Section Abstract Doc Link 2157119 Disease Relevance 0 Pain Relevance 1.59
Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression.
Positive_regulation (increased) of Gene_expression (expression) of beta-endorphin
16) Confidence 0.50 Published 1999 Journal Brain Res. Section Title Doc Link 10448196 Disease Relevance 0.15 Pain Relevance 0.35
We have reported previously that beta-endorphin and morphine administered supraspinally produce analgesia by activating different descending pain inhibitory systems in rats.
Positive_regulation (activating) of Gene_expression (produce) of beta-endorphin associated with pain, analgesia and morphine
17) Confidence 0.49 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2966856 Disease Relevance 0.10 Pain Relevance 0.90
We have previously demonstrated that beta-endorphin and morphine, when administered supraspinally, produce antinociception by activating different descending pain inhibitory systems in both rats and mice.
Positive_regulation (activating) of Gene_expression (produce) of beta-endorphin associated with pain, antinociception and morphine
18) Confidence 0.49 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7969510 Disease Relevance 0.33 Pain Relevance 0.98
Therefore, our results suggest that nonpolarized CD4+ T cells release beta-endorphin, which, through an interaction with MOR, stimulates an upregulation of beta-endorphin expression in the myenteric plexus.
Positive_regulation (upregulation) of Gene_expression (expression) of beta-endorphin in T cells associated with opioid receptor
19) Confidence 0.49 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16959949 Disease Relevance 0.22 Pain Relevance 0.61
The proopiomelanocortin (POMC) gene expression of AtT20 mouse pituitary cells is dependent on cell culture conditions.
Positive_regulation (dependent) of Gene_expression (expression) of POMC in pituitary
20) Confidence 0.49 Published 1994 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Title Doc Link 8003951 Disease Relevance 0 Pain Relevance 0.08

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