INT62774

Context Info Confidence 0.67 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 2.00 Pain Relevance 0.59

Anatomy Link Frequency artery 1 reticulum 1 RSS (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 1 97.24 addiction 1 92.36 Antinociceptive 4 84.52 Pain 46 78.12 agonist 1 73.20 analgesia 10 62.96 Neurotransmitter 1 47.84 nociceptor 1 25.00 Analgesic 8 20.32 cva 10 19.36

Disease Link Frequency Relevance Heat Myocardial Infarction 7 98.24 Angina 1 97.24 Breast Cancer 1 95.00 Sleep Disorders 100 94.60 Anaphylaxis 1 93.60 Nociception 1 92.96 Rhinitis 44 85.52 Thrombosis 1 82.40 Muscular Spasm 1 81.80 Congenital Anomalies 8 79.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Plasma levels of TXB2, LTB4, and SRS-A in systemic artery blood were significantly elevated during the acute stage (within twenty-four hours after the onset of chest pain) of AMI (TXB2, 0.36 ng/mL; LTB4, 0.75 ng/mL; and SRS-A [LTC4+LTD4+LTE4], 0.96 ng/mL compared with those of normal controls (TXB2, 0.18 ng/mL; LTB4, 0.44 ng/mL; and SRS-A (LTC4+LTD4+LTE4], 0.31 ng/mL).

Positive_regulation (elevated) of SRS in artery associated with angina and myocardial infarction

1) Confidence 0.67 Published 1996 Journal Angiology Section Abstract Doc Link 8686958 Disease Relevance 1.02 Pain Relevance 0.10

Stimulation of low emotional value RSs (low rate (LR)-rabbits) exerted a weaker inhibitory influence in 3-5-month old rabbits in comparison with 20-40- and 41-60-day old rabbits both in behavioral and electrophysiological testings.

Positive_regulation (Stimulation) of RSs

2) Confidence 0.34 Published 1999 Journal Brain Res. Section Abstract Doc Link 10407089 Disease Relevance 0.09 Pain Relevance 0.26

Change in the RSDI at the individual level correlated moderately well with changes in the RSS-4, SF-12 PCS, CES-D, and PCRQ.

Positive_regulation (changes) of RSS-4

3) Confidence 0.22 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1308842 Disease Relevance 0.09 Pain Relevance 0

The proportion, however, of RSS 2 to 3 (oriented and cooperative) increased from 10% to 19% and RSS 1 (agitated) decreased from 2% to 0.5% (P = .035).

Positive_regulation (increased) of RSS

4) Confidence 0.05 Published 2010 Journal Crit Care Section Body Doc Link PMC2887194 Disease Relevance 0.33 Pain Relevance 0

This would explain the significantly elevated RSS of CCM2 immunofluorescence detected in the sorbitol-treated blastocysts when compared with glycerol-treated and control blastocysts.

Positive_regulation (elevated) of RSS

5) Confidence 0.02 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0

Following 15 minutes of treatment in 460 mOsm medium, blastocysts cultured in KSOMaa + 0.2 M sorbitol (n = 26) displayed a significant increase in RSS of CCM2 immunofluorescence when compared to blastocysts cultured in normal KSOMaa medium (n = 26) (1.74 ± 0.09 vs. 1.00 ± 0.10, respectively) or KSOMaa containing 1.4% glycerol (n = 27) (1.74 ± 0.09 vs. 0.926 ± 0.077, respectively) (Figure 5F) (P ?

Positive_regulation (increase) of RSS

6) Confidence 0.02 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0

While it has been thought that a change in extracellular calcium concentration is necessary to activate CaSRs, the localization of CaSR on the membrane of the endoplasmic reticulum and the Golgi apparatus [7] suggests that CaSR may be involved in the regulation of intracellular calcium distribution independently of the extracellular calcium.

Positive_regulation (activate) of CaSRs in reticulum

7) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2907400 Disease Relevance 0.48 Pain Relevance 0.23

General Comments

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