INT6278

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Context Info
Confidence 0.59
First Reported 1982
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 11.07
Pain Relevance 14.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
arcuate nucleus 8
hypothalamus 6
corticotroph 4
macrophages 2
plasma 2
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 24 100.00 Very High Very High Very High
imagery 10 100.00 Very High Very High Very High
Morphine 8 100.00 Very High Very High Very High
depression 6 100.00 Very High Very High Very High
Clonidine 3 100.00 Very High Very High Very High
Enkephalin 51 99.98 Very High Very High Very High
dexamethasone 14 99.98 Very High Very High Very High
antinociception 3 99.96 Very High Very High Very High
Dismenorea 3 99.96 Very High Very High Very High
Nicotine 25 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 7 100.00 Very High Very High Very High
Cancer 59 99.98 Very High Very High Very High
Eating Disorder 15 99.98 Very High Very High Very High
Reprotox - General 1 7 99.96 Very High Very High Very High
Skin Cancer 3 99.84 Very High Very High Very High
Neuropathic Pain 14 99.74 Very High Very High Very High
Aids-related Complex 11 99.68 Very High Very High Very High
Nicotine Addiction 3 99.62 Very High Very High Very High
Nelson Syndrome 6 99.54 Very High Very High Very High
Sprains And Strains 64 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results show a significant decrease in the POMC gene expression by the S(-)-enantiomer of SAL.
Negative_regulation (decrease) of Gene_expression (expression) of POMC gene
1) Confidence 0.59 Published 1995 Journal Alcohol Section Abstract Doc Link 8519440 Disease Relevance 0.18 Pain Relevance 0.32
Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression.
Negative_regulation (decreased) of Gene_expression (expression) of beta-endorphin
2) Confidence 0.58 Published 1999 Journal Brain Res. Section Title Doc Link 10448196 Disease Relevance 0.15 Pain Relevance 0.35
Quantitative analysis revealed that cellular expression of POMC mRNA was drastically reduced in the pituitary of knock-out mice in comparison to controls.
Negative_regulation (reduced) of Gene_expression (expression) of POMC mRNA in pituitary associated with targeted disruption
3) Confidence 0.58 Published 2001 Journal Acta Histochem. Section Abstract Doc Link 11700945 Disease Relevance 0.42 Pain Relevance 0.05
Together these results suggest that an elevation of corticosterone is necessary for reduction in melanocortin tone during fasting and with diabetes and is sufficient to induce hypothalamic AGRP mRNA but not to reduce POMC expression.
Neg (not) Negative_regulation (reduce) of Gene_expression (expression) of POMC associated with diabetes mellitus
4) Confidence 0.57 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.19 Pain Relevance 0
Induction of neuropathy resulted in decrease of lumbar pro-opiomelanocortin (POMC) gene expression in wild-type mice, but increase of POMC expression in CCK(2) (-/-) mice.
Negative_regulation (decrease) of Gene_expression (expression) of POMC associated with neuropathic pain and cholecystokinin
5) Confidence 0.57 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15355324 Disease Relevance 0.87 Pain Relevance 1.74
In addition, formalin-induced POMC mRNA expression was significantly reduced by 10 min, pretreatment with i.c.v.
Negative_regulation (reduced) of Gene_expression (expression) of POMC mRNA
6) Confidence 0.56 Published 2008 Journal Neuroscience Section Abstract Doc Link 18329177 Disease Relevance 0.07 Pain Relevance 0.24
In contrast, dexamethasone reduced basal and hCG-stimulated beta-endorphin production (by 50%).
Negative_regulation (reduced) of Gene_expression (production) of beta-endorphin associated with dexamethasone
7) Confidence 0.55 Published 1988 Journal J. Steroid Biochem. Section Abstract Doc Link 2838695 Disease Relevance 0 Pain Relevance 0.09
This is associated with activation on neurones in the NTS, as well as increased AgRP and decreased POMC mRNA expression in the hypothalamus [92].
Negative_regulation (decreased) of Gene_expression (expression) of POMC mRNA in hypothalamus associated with medulla
8) Confidence 0.54 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.18 Pain Relevance 0.95
NPY is thought to be one of the strongest stimuli to feeding [51] perhaps partly acting by inhibiting arcuate nucleus pomc mRNA expression via the Y2 receptor [52].
Negative_regulation (inhibiting) of Gene_expression (expression) of pomc mRNA in arcuate nucleus
9) Confidence 0.47 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.16 Pain Relevance 0.07
Food restriction reduces hypothalamic pomc mRNA expression [49], whereas hypothalamic pomc mRNA expression is increased in overfed rats [50].
Negative_regulation (reduces) of Gene_expression (expression) of pomc mRNA associated with eating disorder
10) Confidence 0.47 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.10 Pain Relevance 0.08
Mouse models that are considered include a transgenic strain with expression of enhanced green fluorescent protein in POMC neurons, facilitating analyses of the cell intrinsic membrane and synaptic properties, and two gene knockout strains exhibiting either a selective absence of beta-endorphin production or a complete loss of all POMC peptides from the pituitary gland and nervous system.
Negative_regulation (absence) of in neurons Gene_expression (production) of beta-endorphin in Mouse associated with targeted disruption and sprains and strains
11) Confidence 0.42 Published 2004 Journal J. Endocrinol. Invest. Section Abstract Doc Link 15481808 Disease Relevance 0.47 Pain Relevance 0.07
Negative correlation of cigarette smoking and dysmenorrhea: reduced prostaglandin synthesis due to beta-endorphin, nicotine, or acrolein antagonism.
Negative_regulation (reduced) of Gene_expression (synthesis) of beta-endorphin associated with nicotine addiction, nicotine and dismenorea
12) Confidence 0.41 Published 1989 Journal Med. Hypotheses Section Title Doc Link 2523509 Disease Relevance 0.30 Pain Relevance 0.39
A stimulating effect of intracerebroventricular administration on locomotor activity was also induced by shorter homologues of dermorphin and [D-Ala2, Leu5]enkephalinamide, while beta-endorphin produced a depression.
Negative_regulation (depression) of Gene_expression (produced) of beta-endorphin associated with depression, eae and intracerebroventricular
13) Confidence 0.41 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7128688 Disease Relevance 0.18 Pain Relevance 0.73
Furthermore, LPS-induced IL-1 production by macrophages (in the absence of added beta-endorphin) was also partially inhibited following treatment with naloxone, suggesting that opioids derived from activated macrophages may also modulate IL-1 generation and secretion.
Negative_regulation (inhibited) of Gene_expression (production) of beta-endorphin in macrophages associated with narcan and opioid
14) Confidence 0.41 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.32
Penk gene expression was not modulated by acute MDMA, but a decrease of Pomc gene expression was observed, which was not antagonized by NTI.
Negative_regulation (decrease) of Gene_expression (expression) of Pomc gene associated with enkephalin
15) Confidence 0.40 Published 2009 Journal Addict Biol Section Abstract Doc Link 19523041 Disease Relevance 0 Pain Relevance 0.92
-endorphin, into the PVN reduces POMC gene expression in the arcuate nucleus, implying a negative feedback system involving melanocortins only [142].
Negative_regulation (reduces) of Gene_expression (expression) of POMC gene in arcuate nucleus
16) Confidence 0.40 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.19 Pain Relevance 0.07
Reduced sodium appetite and increased oxytocin gene expression in mutant mice lacking beta-endorphin.
Negative_regulation (Reduced) of Gene_expression (expression) of beta-endorphin
17) Confidence 0.39 Published 2003 Journal Neuroscience Section Title Doc Link 14580937 Disease Relevance 0.22 Pain Relevance 0.27
POMC/CART and NPY/AgRP neuronal pathways from the arcuate nucleus
Negative_regulation (/) of Gene_expression (neuronal) of POMC in arcuate nucleus
18) Confidence 0.39 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.13 Pain Relevance 0.11
Also, approximately one-third of POMC/CART neurones express glutamic acid decarboxylase (GAD) mRNA [47].
Negative_regulation (neurones) of Gene_expression (express) of POMC associated with generalized anxiety disorder
19) Confidence 0.39 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.54 Pain Relevance 0.41
In the ob/ob mouse, agrp gene expression is increased 5–10 fold compared with wild type [74,75], whereas the absence of leptin only reduces pomc gene expression by approximately two-fold [76].
Negative_regulation (reduces) of Gene_expression (expression) of pomc gene associated with obesity
20) Confidence 0.39 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.26 Pain Relevance 0.15

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