INT62784

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Context Info
Confidence 0.65
First Reported 1996
Last Reported 2011
Negated 8
Speculated 1
Reported most in Body
Documents 46
Total Number 52
Disease Relevance 15.95
Pain Relevance 3.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NT5E) plasma membrane (NT5E) DNA metabolic process (NT5E)
cytoplasm (NT5E)
Anatomy Link Frequency
stem cell 5
adipocytes 3
osteoblasts 2
hematopoietic cell 2
chondroblasts 2
NT5E (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 31 99.76 Very High Very High Very High
Myofascial pain syndrome 4 99.30 Very High Very High Very High
rheumatoid arthritis 67 97.88 Very High Very High Very High
Catechol-O-methyltransferase 232 97.28 Very High Very High Very High
adenocard 18 96.88 Very High Very High Very High
imagery 11 95.32 Very High Very High Very High
Dopamine 87 91.84 High High
agonist 26 91.12 High High
Kappa opioid receptor 6 90.20 High High
antidepressant 4 90.08 High High
Disease Link Frequency Relevance Heat
Cancer 220 99.90 Very High Very High Very High
INFLAMMATION 380 99.44 Very High Very High Very High
Disease 469 99.40 Very High Very High Very High
Temporomandibular Joint Disorders 4 99.30 Very High Very High Very High
Obesity 100 99.24 Very High Very High Very High
Aging 11 99.20 Very High Very High Very High
Rheumatoid Arthritis 69 97.88 Very High Very High Very High
Pancreatitis 76 97.56 Very High Very High Very High
Adhesions 61 96.40 Very High Very High Very High
Recurrence 111 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hydrolysis of these compounds yielded the secondary amino alcohols l-7a-c, u-7a-c, ent-l-7a-c and ent-u-7a-c and upon reductive methylation of l-7b-c, u-7b-c, ent-l-7b-c and ent-u-7b-c with CH2O and NaCNBH3 the tertiary amino alcohols l-7d-e, u-7d-e, ent-l-7d-e and ent-u-7d-e were obtained.
Gene_expression (obtained) of ent
1) Confidence 0.65 Published 1996 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 8687279 Disease Relevance 0 Pain Relevance 0.04
Hydrolysis of these compounds yielded the secondary amino alcohols l-7a-c, u-7a-c, ent-l-7a-c and ent-u-7a-c and upon reductive methylation of l-7b-c, u-7b-c, ent-l-7b-c and ent-u-7b-c with CH2O and NaCNBH3 the tertiary amino alcohols l-7d-e, u-7d-e, ent-l-7d-e and ent-u-7d-e were obtained.
Gene_expression (yielded) of ent
2) Confidence 0.65 Published 1996 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 8687279 Disease Relevance 0 Pain Relevance 0.04
Upon reduction of 5a-c and ent-5a-c the amido alcohols l-6a-c, u-6a-c, ent-l-6a-c and ent-u-6a-c were obtained.
Gene_expression (obtained) of ent
3) Confidence 0.65 Published 1996 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 8687279 Disease Relevance 0 Pain Relevance 0.04
Hydrolysis of these compounds yielded the secondary amino alcohols l-7a-c, u-7a-c, ent-l-7a-c and ent-u-7a-c and upon reductive methylation of l-7b-c, u-7b-c, ent-l-7b-c and ent-u-7b-c with CH2O and NaCNBH3 the tertiary amino alcohols l-7d-e, u-7d-e, ent-l-7d-e and ent-u-7d-e were obtained.
Gene_expression (yielded) of ent
4) Confidence 0.65 Published 1996 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 8687279 Disease Relevance 0 Pain Relevance 0.04
Hydrolysis of these compounds yielded the secondary amino alcohols l-7a-c, u-7a-c, ent-l-7a-c and ent-u-7a-c and upon reductive methylation of l-7b-c, u-7b-c, ent-l-7b-c and ent-u-7b-c with CH2O and NaCNBH3 the tertiary amino alcohols l-7d-e, u-7d-e, ent-l-7d-e and ent-u-7d-e were obtained.
Gene_expression (obtained) of ent
5) Confidence 0.65 Published 1996 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 8687279 Disease Relevance 0 Pain Relevance 0.04
Upon reduction of 5a-c and ent-5a-c the amido alcohols l-6a-c, u-6a-c, ent-l-6a-c and ent-u-6a-c were obtained.
Gene_expression (obtained) of ent
6) Confidence 0.65 Published 1996 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 8687279 Disease Relevance 0 Pain Relevance 0.05
Dentists need to be alert to the possibility of primary ENT disorders in patients who present with TMD symptoms, as should ENT physicians be familiar with the clinical presentation of TMD, especially in those patients who present with ENT symptoms but no sign of ENT disease.
Gene_expression (present) of ENT associated with myofascial pain syndrome and disease
7) Confidence 0.65 Published 1999 Journal Aust Endod J Section Abstract Doc Link 11411075 Disease Relevance 0.54 Pain Relevance 0.37
Using the nucleoside-transporter-deficient PK15NTD cells that stably express equilibrative nucleoside transport (ENT) 1 and ENT2, it was found that the inhibitory effect of sulindac sulfide on ENT1 was greater than that on ENT2.
Gene_expression (express) of ENT
8) Confidence 0.58 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19379728 Disease Relevance 0.14 Pain Relevance 0.94
MSC have been defined as the cells having plastic-adherence when maintained under standard culture conditions, must have the ability of osteogenic, adipogenic and chondrogenic differentiation, must express CD73, CD90, and CD105, and must lack expression of hematopoietic lineage markers c-kit, CD14, CD34, CD 45, CD 11b, CD 29, CD79?
Gene_expression (express) of CD73
9) Confidence 0.37 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.36 Pain Relevance 0
The examined stem cell markers, CD44, CD73, CD166, CD105, CD90 and STRO1 showed stable expression level during the whole expansion period proving the results obtained by FACS analyses.
Gene_expression (expression) of CD73 in stem cell
10) Confidence 0.35 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.07 Pain Relevance 0
The optimal surgical treatment is en bloc resection with ipsilateral thyroid lobectomy and removal of any enlarged or abnormal lymph nodes.
Gene_expression (resection) of en bloc in lymph nodes
11) Confidence 0.33 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1187928 Disease Relevance 1.31 Pain Relevance 0.03
Therefore en bloc resection of the mass along with the total thyroid gland and the connective tissue apparently involved in the tumour was performed.
Gene_expression (resection) of en bloc in thyroid gland associated with cancer
12) Confidence 0.33 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1187928 Disease Relevance 0.49 Pain Relevance 0
Adipose tissue-derived stem cells are understood to express surface markers of CD9, CD10, CD13, CD29, CD44, CD49d, CD49e, CD54, CD55, CD59, CD73, CD90, CD105, CD146, CD166, and STRO-1, and lack hematopoietic lineage markers CD11b, CD14, CD19, CD34, and CD45 [20,34,50-53].
Neg (lack) Gene_expression (express) of CD73 in stem cells associated with obesity
13) Confidence 0.26 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.22 Pain Relevance 0.06
MSCs strongly expressed surface proteins CD73, CD105, CD29, CD44, HLAABC, and weak-to-moderate expression of SSEA-4.
Gene_expression (expressed) of CD73
14) Confidence 0.22 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2847339 Disease Relevance 0.05 Pain Relevance 0
The harvested cells were also analyzed for the expression of CD73, CD105, CD45, SSEA4, HLADR, HLAABC, CD14, CD31, CD44, CD29, and vWF markers, by flow cytometry.


Spec (analyzed) Gene_expression (expression) of CD73
15) Confidence 0.22 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2847339 Disease Relevance 0 Pain Relevance 0
The microarray gene expression analysis of these cells indicates that the cells are negative for the hematopoietic markers CD34, CD49c, CD49d, CD62e, CD62p, CD106, CD117, CD133, CD235a, HLA-DRB4, HLA-DRB4 and HAS1, and positive for the mesenchymal markers CD13, CD29, CD44, CD49a/b, CD49e, CD73, CD105 and vimentin [18], supporting their USSCs/MSC origin.
Neg (negative) Gene_expression (negative) of CD73
16) Confidence 0.21 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0 Pain Relevance 0
Classically, MSC are defined as being able to adhere to plastic, expressing CD29, CD73, CD44, CD90, CD105 antigens, and not expressing the hematopoietic cell markers CD34, CD45, and MHC class II antigen [35], although none of these markers appears to be exclusively expressed on MSC [36].
Neg (not) Gene_expression (expressing) of CD73 in hematopoietic cell
17) Confidence 0.21 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0 Pain Relevance 0
Classically, MSC are defined as being able to adhere to plastic, expressing CD29, CD73, CD44, CD90, CD105 antigens, and not expressing the hematopoietic cell markers CD34, CD45, and MHC class II antigen [35], although none of these markers appears to be exclusively expressed on MSC [36].
Neg (not) Gene_expression (expressing) of CD73 in hematopoietic cell
18) Confidence 0.21 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0 Pain Relevance 0
Both the MSCs studied expressed stem cell markers CD73 and SSEA4 and their expression was not altered on treatment with IFN?
Gene_expression (expressed) of CD73 in stem cell
19) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.29 Pain Relevance 0.18
Within the stromal compartment (CD45-negative cells), large populations expressing CD73 (median 81.3%, n = 8) and CD105 (median 86%, n = 3) and smaller populations expressing HLA-DR (median 36.5%, n = 6) and CD146 (median 5.6%, n = 8), also in part CD34-positive, were seen (Figure 2e).
Gene_expression (expressing) of CD73
20) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.06 Pain Relevance 0

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