INT62787

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm1) plasma membrane (Chrm1) signal transducer activity (Chrm1)
Chrm1 (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 1 73.84 Quite High
Disease Link Frequency Relevance Heat
Convulsion 1 85.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At micromolar concentrations, compounds 1, 12, and 13 inhibited the binding of [3H]-pirenzepine and of [3H]-di-o-tolylguanidine respectively on M1 and sigma receptors; in the last case comp. 13 was more active (IC50 = 0.3 microM) than the epimeric 1.
Negative_regulation (inhibited) of M1 Binding (binding) of
1) Confidence 0.43 Published 1996 Journal Farmaco Section Abstract Doc Link 8688138 Disease Relevance 0.09 Pain Relevance 0.07

General Comments

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