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Context Info
Confidence 0.43
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.07

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signal transduction (Chrm1) plasma membrane (Chrm1) signal transducer activity (Chrm1)
Chrm1 (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 1 73.84 Quite High
Disease Link Frequency Relevance Heat
Convulsion 1 85.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At micromolar concentrations, compounds 1, 12, and 13 inhibited the binding of [3H]-pirenzepine and of [3H]-di-o-tolylguanidine respectively on M1 and sigma receptors; in the last case comp. 13 was more active (IC50 = 0.3 microM) than the epimeric 1.
Negative_regulation (inhibited) of M1 Binding (binding) of
1) Confidence 0.43 Published 1996 Journal Farmaco Section Abstract Doc Link 8688138 Disease Relevance 0.09 Pain Relevance 0.07

General Comments

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