INT628

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Context Info
Confidence 0.58
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.44
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GAST) extracellular region (GAST)
Anatomy Link Frequency
plasma 2
pituitary 1
lung 1
GAST (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 2 100.00 Very High Very High Very High
nud 9 99.64 Very High Very High Very High
isoflurane 2 98.48 Very High Very High Very High
imagery 1 97.92 Very High Very High Very High
Somatostatin 14 97.52 Very High Very High Very High
substance P 4 96.80 Very High Very High Very High
Potency 1 96.64 Very High Very High Very High
Calcitonin gene-related peptide 4 96.24 Very High Very High Very High
peptic ulcer disease 4 95.44 Very High Very High Very High
Catecholamine 1 95.00 High High
Disease Link Frequency Relevance Heat
Lung Cancer 6 99.70 Very High Very High Very High
Dyspepsia 9 99.64 Very High Very High Very High
Gastroesophageal Reflux Disease 50 99.30 Very High Very High Very High
Syndrome 7 99.16 Very High Very High Very High
Cancer 4 97.60 Very High Very High Very High
Gastrinoma 2 95.96 Very High Very High Very High
Disease 12 95.44 Very High Very High Very High
Ulcers 11 95.12 Very High Very High Very High
Heart Neoplasms 1 94.28 High High
Duodenal Ulcer 2 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resection of the lung tumor resulted in a decrease in gastrin levels to normal values.
Negative_regulation (decrease) of gastrin in lung associated with lung cancer
1) Confidence 0.58 Published 2001 Journal Gastroenterology Section Abstract Doc Link 11266390 Disease Relevance 1.91 Pain Relevance 0.21
BACKGROUND: In the present investigation we compared the consumption of desflurane (DES) and isoflurane (ISO) using a standardized minimal-flow protocol with a forced reduction of the fresh gas flow (FGF).
Negative_regulation (reduction) of gas associated with isoflurane
2) Confidence 0.57 Published 2006 Journal Anaesthesist Section Abstract Doc Link 16830125 Disease Relevance 0 Pain Relevance 0.16
In 3 patients with Zollinger-Ellison syndrome, treated in the same way, elevated serum gastrin was reduced by about 50% and acid secretion by more than 90%.
Negative_regulation (reduced) of gastrin associated with syndrome
3) Confidence 0.48 Published 1976 Journal Z Gastroenterol Verh Section Abstract Doc Link 64056 Disease Relevance 0.51 Pain Relevance 0.17
The inhibition of meal-stimulated gastric acid secretion was not a consequence of the reduction of serum gastrin.
Negative_regulation (reduction) of gastrin
4) Confidence 0.42 Published 1987 Journal Prostaglandins Section Abstract Doc Link 3122277 Disease Relevance 0.16 Pain Relevance 0.08
Reducing waste is another approach, and volatile anesthetics are an appropriate target in that simple reduction of fresh gas-flow (FGF) rates is effective.
Negative_regulation (reduction) of gas
5) Confidence 0.41 Published 1999 Journal J Clin Monit Comput Section Abstract Doc Link 12568134 Disease Relevance 0 Pain Relevance 0.09
Ecabet significantly decreased plasma gastrin-IS levels compared with placebo.
Negative_regulation (decreased) of gastrin in plasma
6) Confidence 0.34 Published 2005 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 15969937 Disease Relevance 0 Pain Relevance 0.60
Table 1 illustrates that pretreated Patients with GERD showed heartburn, epigastric pain, and significant decrease in LES pressure, residual pressure, relaxation percentage, pH, serum gastrin and mean melatonin level and a significant increase in relaxation duration and basal acid output (BAO) relative to control group.
Negative_regulation (decrease) of gastrin associated with gastroesophageal reflux disease and nud
7) Confidence 0.32 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.97 Pain Relevance 0.09
CRF significantly (P less than 0.01) inhibited gastric acid secretion, but not plasma gastrin concentrations stimulated by an 8% liquid peptone meal.
Negative_regulation (inhibited) of gastrin in plasma
8) Confidence 0.20 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3544874 Disease Relevance 0.22 Pain Relevance 0.21
Octreotide has effects similar to those of somatostatin but with greater potency and longer duration of action; these effects include inhibition of pituitary release of growth hormone and thyrotropin, inhibition of glucagon or insulin release, and inhibition of the secretion of various gastrointestinal tract hormones (e.g. serotonin, pepsin, gastrin, secretin, motilin, vasoactive intestinal peptide and pancreatic peptides) [9,10].
Negative_regulation (inhibition) of gastrin in pituitary associated with somatostatin, serotonin and potency
9) Confidence 0.07 Published 2005 Journal Crit Care Section Body Doc Link PMC1414034 Disease Relevance 0.67 Pain Relevance 0.26
The CCKB receptor is a good example of this phenomenon, as truncation of its N-terminus reduces its affinity for both gastrin and CCK-8 (Miyake, 1995).
Negative_regulation (reduces) of gastrin
10) Confidence 0.06 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2839267 Disease Relevance 0 Pain Relevance 0.21

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