INT62808

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1996
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.30
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SLC2A4) small molecule metabolic process (SLC2A4) plasma membrane (SLC2A4)
carbohydrate metabolic process (SLC2A4) transmembrane transport (SLC2A4) cytoplasm (SLC2A4)
Anatomy Link Frequency
adipocytes 2
muscle 1
vesicles 1
SLC2A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 20 89.72 High High
anesthesia 5 87.48 High High
Inflammation 9 59.96 Quite High
cytokine 10 38.68 Quite Low
behavioral therapy 3 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 394 99.84 Very High Very High Very High
Death 4 98.06 Very High Very High Very High
Hyperinsulinism 5 97.64 Very High Very High Very High
Targeted Disruption 27 97.08 Very High Very High Very High
Impaired Glucose Tolerance 34 89.72 High High
Metabolic Syndrome 52 86.56 High High
Insulin Resistance 10 79.60 Quite High
Hypertension 7 78.44 Quite High
Body Weight 5 77.24 Quite High
Cardiovascular Disease 5 68.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucose ingestion increased the plasma membrane content of GLUT4 per gram muscle (3,524 +/- 729 vs. 4,473 +/- 952 arbitrary units for basal and 60 min, respectively; P < 0.005).
Positive_regulation (increased) of GLUT4 in muscle
1) Confidence 0.50 Published 1996 Journal Diabetes Section Abstract Doc Link 8690151 Disease Relevance 0 Pain Relevance 0.09
Transporter-mediated glucose transport into plasma membrane vesicles was also significantly increased (130 +/- 11 vs. 224 +/- 38 pmol.mg-1.s-1; P < 0.017), whereas the calculated ratio of glucose transport to GLUT4, an indication of transporter functional activity, was not significantly increased 60 min after glucose ingestion (2.3 +/- 0.4 vs. 3.0 +/- 0.5 pmol.GLUT4 arbitrary units-1.s-1; P < 0.17).
Neg (not) Positive_regulation (increased) of GLUT4 in vesicles
2) Confidence 0.50 Published 1996 Journal Diabetes Section Abstract Doc Link 8690151 Disease Relevance 0 Pain Relevance 0.07
At the cellular level several genes, including cell death-inducing DFFA-like effector a (CIDEA), uncoupling protein-1 (UCP-1), and glucose transporter 4 (GLUT4) are upregulated in adipocytes from RIPKO as compared to WT-mice.
Positive_regulation (upregulated) of GLUT4 in adipocytes associated with obesity and death
3) Confidence 0.48 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.99 Pain Relevance 0.04
Furthermore, we observed that primarily mRNA levels of the glucose transporter GLUT4 but not GLUT1 were increased by RIP140 silencing in human fat cells, which is in line with data from knock out mice [5].
Positive_regulation (increased) of GLUT4 in fat cells associated with targeted disruption and obesity
4) Confidence 0.32 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.97 Pain Relevance 0
RIP140 silencing significantly increased mRNA levels of GLUT4 and UCP-1 compared to control cells (P < 0.01 for both) (Figure 4C).
Positive_regulation (increased) of GLUT4
5) Confidence 0.32 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.58 Pain Relevance 0
When IRS-1 is activated, it stimulates GLUT 4, with consequent regulation of glucose and lipid intracellular metabolism.
Positive_regulation (stimulates) of GLUT 4
6) Confidence 0.10 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.63 Pain Relevance 0.03
In addition to (or possibly as a result of) the increased activity of the insulin signaling cascade, an increase in GLUT-4 protein concentration has also been observed with RT in humans [96] and rodents [112–114].
Positive_regulation (increase) of GLUT-4 protein
7) Confidence 0.09 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.12 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox