INT62815

Context Info Confidence 0.41 First Reported 1996 Last Reported 1996 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.56 Pain Relevance 0.24

cell proliferation (Gnl3) nucleoplasm (Gnl3) nucleolus (Gnl3) nucleus (Gnl3)

Anatomy Link Frequency neurons 1 Gnl3 (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 3 99.84 noradrenaline 1 93.84 antagonist 1 92.60 anesthesia 1 25.00

Disease Link Frequency Relevance Heat Stupor 2 83.48 Head Trauma 4 77.84 Coma 2 68.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Taken together with the finding that NS-3 did not bind to dopamine, adrenaline or muscarine receptors, it is suggested that NS-3 may restore the disturbance of consciousness by activating the brain dopamine, noradrenaline and acetylcholine neurons without stimulating these receptors directly.

NS-3 Neg (not) Binding (bind) of in neurons associated with dopamine and noradrenaline

1) Confidence 0.41 Published 1996 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 8690305 Disease Relevance 0.56 Pain Relevance 0.24

General Comments

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