INT6282

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 6.74
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
anterior 1
muscle 1
ear 1
[[Del(7)Tyr<c-1DThWb>-p]] (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 18 99.84 Very High Very High Very High
tolerance 28 98.92 Very High Very High Very High
dexamethasone 3 98.14 Very High Very High Very High
narcan 3 97.76 Very High Very High Very High
opioid receptor 3 96.16 Very High Very High Very High
cINOD 3 96.02 Very High Very High Very High
Inflammation 46 92.80 High High
opiate 3 75.00 Quite High
Acupuncture 3 75.00 Quite High
rheumatoid arthritis 3 70.56 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 100 100.00 Very High Very High Very High
Immunization 41 99.96 Very High Very High Very High
Ocular Injury 58 98.92 Very High Very High Very High
Injury 33 98.92 Very High Very High Very High
Granuloma 9 96.72 Very High Very High Very High
INFLAMMATION 46 92.80 High High
Pressure And Volume Under Development 9 91.44 High High
Arthritis 3 75.00 Quite High
Keloid Scars 1 74.28 Quite High
Macular Edema 2 70.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclosporin A (50-100 mg/kg/day, orally) suppressed DTH GRA most effectively when administered on days 3 and 4 (66% and 97%) of the five-day granuloma response (treatment was ineffective when given on days 1 and 2).
Negative_regulation (suppressed) of DTH GRA associated with granuloma
1) Confidence 0.57 Published 1990 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2292466 Disease Relevance 0.58 Pain Relevance 0.25
In 7- to 9-week-old male BALB/c, C57BL/6 and ddY mice, significant suppression of the DTH was observed when Acu had been applied once per day for three consecutive days before TNCB challenge.
Negative_regulation (suppression) of DTH associated with hypersensitivity and electroacupuncture
2) Confidence 0.51 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1325956 Disease Relevance 0.61 Pain Relevance 0.45
The "interferon alpha-inducers" Tilorone, U-54,461, and U-56,499 were also potent inhibitors of the DTH GRA response; U-54,462, a weak interferon alpha-inducer, was inactive.
Negative_regulation (inhibitors) of DTH GRA
3) Confidence 0.42 Published 1990 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2292466 Disease Relevance 0.59 Pain Relevance 0.25
This Acu-evoked DTH suppression was blocked dose-relatedly by pretreatment of systemic naloxone hydrochloride, indicating that opioid receptor-mediated mechanisms are involved in this immune response.
Negative_regulation (suppression) of DTH associated with hypersensitivity, narcan, opioid receptor and electroacupuncture
4) Confidence 0.37 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1325956 Disease Relevance 0.60 Pain Relevance 0.46
Application to another point (at a middle area of the femoral muscle) failed to suppress the DTH to TNCB.
Neg (failed) Negative_regulation (suppress) of DTH in muscle associated with hypersensitivity
5) Confidence 0.37 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1325956 Disease Relevance 0.61 Pain Relevance 0.46
NSAIDs, with the exception of flurbiprofen, showed little activity in comparison with the steroids dexamethasone (1-3 mg/kg/day, orally) and prednisolone (3-10 mg/kg/day, orally), which caused significant suppression of DTH GRA tissue (65-76% and 26-68%, respectively).
Negative_regulation (suppression) of DTH GRA associated with cinod and dexamethasone
6) Confidence 0.37 Published 1990 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2292466 Disease Relevance 0.61 Pain Relevance 0.23
Subsequently, approximately seven days after immunization, inhibition of DTH can be observed to an antigen-specific challenge delivered subcutaneously to the recipient ear pinnae.
Negative_regulation (inhibition) of DTH in ear associated with hypersensitivity and immunization
7) Confidence 0.07 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.34 Pain Relevance 0.03
Interestingly, intracameral inoculations resulted in anterior segment injuries as well, despite the induction of ACAID confirmed by DTH suppression (Figure 1).
Negative_regulation (suppression) of DTH in anterior associated with hypersensitivity and injury
8) Confidence 0.05 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 1.00 Pain Relevance 0.14
As presented in Figure 1, this alteration in the protocol did not affect the ability of ACAID to suppress DTH responses as this form of tolerance was detectable up to 24 days post IC inoculation.


Negative_regulation (suppress) of DTH associated with hypersensitivity and tolerance
9) Confidence 0.05 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.35 Pain Relevance 0.05
A penetrating ocular injury 24 h and 48 h following AC injection led to a marked DTH response, a downregulation of TGF-?
Negative_regulation (downregulation) of DTH associated with hypersensitivity and ocular injury
10) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.79 Pain Relevance 0.05
A significantly decreased DTH response was observed in the AC-injection group as well as in mice that received a penetrating injury at 72 h and 120 h following AC-injection of OVA.
Negative_regulation (decreased) of DTH associated with injury and hypersensitivity
11) Confidence 0.03 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2255028 Disease Relevance 0.67 Pain Relevance 0

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