INT62821

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Context Info
Confidence 0.54
First Reported 1996
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 12.24
Pain Relevance 4.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAM1) aging (VCAM1) cell adhesion (VCAM1)
plasma membrane (VCAM1)
Anatomy Link Frequency
lymphocytes 8
leukocytes 4
plasma 2
visceral organs 2
endothelial cells 2
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 14 99.98 Very High Very High Very High
Inflammation 275 99.92 Very High Very High Very High
substance P 32 98.92 Very High Very High Very High
antagonist 11 98.64 Very High Very High Very High
rheumatoid arthritis 102 96.36 Very High Very High Very High
Analgesic 2 95.64 Very High Very High Very High
Arthritis 1 92.12 High High
cINOD 20 91.24 High High
Neuropeptide 24 87.36 High High
c fibre 1 86.44 High High
Disease Link Frequency Relevance Heat
Adhesions 70 100.00 Very High Very High Very High
INFLAMMATION 260 99.92 Very High Very High Very High
Rheumatoid Arthritis 103 96.36 Very High Very High Very High
Cirrhosis 46 88.64 High High
Pancreatic Cancer 11 88.16 High High
Graft Vs Host Disease 4 86.88 High High
Increased Venous Pressure Under Development 16 86.56 High High
Stress 86 86.40 High High
Death 24 85.00 Quite High
Apoptosis 8 84.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vascular cell adhesion molecule 1 expression was only blocked by the inhalational anesthetics and not by morphine.
Negative_regulation (blocked) of Gene_expression (expression) of Vascular cell adhesion molecule 1
1) Confidence 0.54 Published 2008 Journal Anesthesiology Section Body Doc Link 18212564 Disease Relevance 0.06 Pain Relevance 0
The results of the present study suggest that the anti-atherogenic effect of hematein is not related to control of the plasma lipid profile but probably related to the inhibition of VCAM-1 and MCP-1 expression resulting in an amelioration of lesion development in the rabbit.
Negative_regulation (inhibition) of Gene_expression (expression) of VCAM-1 in plasma
2) Confidence 0.49 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11689202 Disease Relevance 0.31 Pain Relevance 0
Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression.
Spec (possible) Negative_regulation (reducing) of Gene_expression (expression) of VCAM-1
3) Confidence 0.49 Published 2001 Journal Atherosclerosis Section Title Doc Link 11689202 Disease Relevance 0.36 Pain Relevance 0.14
All patients showed various degrees of VCAM1 expression.
Negative_regulation (degrees) of Gene_expression (expression) of VCAM1
4) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 0.86 Pain Relevance 0.08
Increased HDMEC VCAM-1 mRNA expression was detected 1 h after the addition of SP, with peak mRNA increase at 6-9 h postinduction.
Negative_regulation (detected) of Gene_expression (expression) of HDMEC VCAM-1 mRNA associated with substance p
5) Confidence 0.37 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.13 Pain Relevance 0.72
The functional significance of HO-1 induction was revealed by celecoxib-mediated inhibition of VCAM-1 expression, a response reversed by the HO-1 antagonist zinc protoporphyrin.
Negative_regulation (inhibition) of Gene_expression (expression) of VCAM-1 associated with antagonist
6) Confidence 0.37 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20083195 Disease Relevance 0.29 Pain Relevance 0.43
Aceclofenac, diclofenac, and indomethacin, but not piroxicam, were able to inhibit PBL adhesion to HUVEC or rVCAM-1.
Negative_regulation (inhibit) of Gene_expression (adhesion) of rVCAM-1 in PBL
7) Confidence 0.36 Published 1998 Journal Arthritis Rheum. Section Body Doc Link 9751102 Disease Relevance 0 Pain Relevance 0
Pretreatment of diclofenac inhibited LPS-induced expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in HUVEC, determined by flow cytometry and a cellular enzyme-linked immunosorbent assay (cell-ELISA).
Negative_regulation (inhibited) of Spec (determined) Gene_expression (expression) of VCAM-1 associated with diclofenac and adhesions
8) Confidence 0.35 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.37 Pain Relevance 0.39
These data demonstrate that diclofenac is capable of inhibiting the expression of E-selectin, ICAM-1 and VCAM-1 in HUVEC.
Negative_regulation (inhibiting) of Gene_expression (expression) of VCAM-1 associated with diclofenac
9) Confidence 0.35 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.31 Pain Relevance 0.36
All four agents prevented TNF-alpha-induced mRNA and protein expression of intracellular cell adhesion molecule 1.
Negative_regulation (prevented) of Gene_expression (expression) of intracellular cell adhesion molecule 1
10) Confidence 0.35 Published 2008 Journal Anesthesiology Section Body Doc Link 18212564 Disease Relevance 0.07 Pain Relevance 0
Haplodeficiency of FOXF1 abolishes the expression of VCAM1 and HGF and leads to structural defects in the gallbladder and other visceral organs [59].
Negative_regulation (abolishes) of Gene_expression (expression) of VCAM1 in visceral organs
11) Confidence 0.33 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.14 Pain Relevance 0.08
Furthermore, GSPE treatment significantly decreased TNFalpha-induced adherence of T-cells to HUVEC by inhibiting VCAM-1 expression.
Negative_regulation (inhibiting) of Gene_expression (expression) of VCAM-1 in T-cells
12) Confidence 0.32 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12074978 Disease Relevance 0.75 Pain Relevance 0.10
RESULTS: The expression of CD11b and CD18 on neutrophils and neutrophil-dependent adhesion to endothelial cells elicited by HPE were inhibited by lansoprazole and omeprazole at clinical relevant doses, and the expression of ICAM-1 and VCAM-1 on endothelial cells and endothelial-dependent neutrophil adherence induced by IL-1beta were also inhibited by lansoprazole and omeprazole at similar doses.
Negative_regulation (inhibited) of Gene_expression (expression) of VCAM-1 in neutrophil
13) Confidence 0.29 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10807407 Disease Relevance 0.23 Pain Relevance 0
In addition to inhibition of DNA synthesis in lymphocytes, depletion of guanosine nucleotides suppresses the expression of several adhesion receptors including vascular cell adhesion molecule 1 (VCAM-1), E-selectin, and P-selectin on vascular endothelial cells.9 This interferes with the attachment of leukocytes to endothelial cells and prevents the recruitment of lymphocytes and monocytes to sites of inflammation.10,11 Suppression of mononuclear cell recruitment is another mechanism by which MMF decreases acute and chronic graft rejection.
Negative_regulation (suppresses) of Gene_expression (expression) of vascular cell adhesion molecule 1 in leukocytes associated with inflammation, graft vs host disease and adhesions
14) Confidence 0.26 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.38 Pain Relevance 0.08
In addition to inhibition of DNA synthesis in lymphocytes, depletion of guanosine nucleotides suppresses the expression of several adhesion receptors including vascular cell adhesion molecule 1 (VCAM-1), E-selectin, and P-selectin on vascular endothelial cells.9 This interferes with the attachment of leukocytes to endothelial cells and prevents the recruitment of lymphocytes and monocytes to sites of inflammation.10,11 Suppression of mononuclear cell recruitment is another mechanism by which MMF decreases acute and chronic graft rejection.
Negative_regulation (suppresses) of Gene_expression (expression) of VCAM-1 in leukocytes associated with inflammation, graft vs host disease and adhesions
15) Confidence 0.26 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.38 Pain Relevance 0.08
We demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of Curcuma longa, diferuloylmethane is most potent in inhibiting TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin on human umbilical vein endothelial cells.
Negative_regulation (inhibiting) of Gene_expression (expression) of VCAM-1 in endothelial cells
16) Confidence 0.25 Published 1999 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 10576620 Disease Relevance 0.25 Pain Relevance 0.17
Expression of E-selectin and VCAM-1 was significantly reduced by anti-TNF therapy [36].
Negative_regulation (reduced) of Gene_expression (Expression) of VCAM-1
17) Confidence 0.25 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 1.31 Pain Relevance 0.43
These substances are expected to reduce the infiltration of inflammatory cells (lymphocytes and monocytes) related to chronic inflammation by inhibiting the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells [39].
Negative_regulation (inhibiting) of Gene_expression (expression) of VCAM-1 in lymphocytes associated with inflammation and adhesions
18) Confidence 0.17 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 1.19 Pain Relevance 0.24
These substances are expected to reduce the infiltration of inflammatory cells (lymphocytes and monocytes) related to chronic inflammation by inhibiting the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells [39].
Negative_regulation (inhibiting) of Gene_expression (expression) of vascular cell adhesion molecule-1 in lymphocytes associated with inflammation and adhesions
19) Confidence 0.13 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 1.19 Pain Relevance 0.24
Figure 6A, using cell surface RIA, demonstrates that curcumin effectively inhibited the ICAM-1 and VCAM surface expression in response to TNF?
Negative_regulation (inhibited) of Gene_expression (expression) of VCAM
20) Confidence 0.11 Published 2008 Journal Gut Section Body Doc Link PMC2582343 Disease Relevance 0.43 Pain Relevance 0.13

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