INT62822

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Context Info
Confidence 0.66
First Reported 1996
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 28.04
Pain Relevance 4.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELE) cell adhesion (SELE) plasma membrane (SELE)
Anatomy Link Frequency
endothelial cells 16
macrophage 2
epithelium 2
joints 2
coronary artery 2
SELE (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 95 99.98 Very High Very High Very High
diclofenac 7 99.70 Very High Very High Very High
Nicotine 20 99.42 Very High Very High Very High
cva 70 98.80 Very High Very High Very High
Inflammation 338 97.72 Very High Very High Very High
Inflammatory response 37 95.40 Very High Very High Very High
alcohol 3 92.68 High High
rheumatoid arthritis 68 92.48 High High
cINOD 10 90.68 High High
COX2 2 90.16 High High
Disease Link Frequency Relevance Heat
Adhesions 317 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 159 99.72 Very High Very High Very High
Neuropathy 80 99.40 Very High Very High Very High
Diabetes Mellitus 394 99.28 Very High Very High Very High
Necrosis 28 99.04 Very High Very High Very High
Cv General 3 Under Development 72 98.80 Very High Very High Very High
Cancer 64 98.68 Very High Very High Very High
Coronary Vasospasm 7 98.64 Very High Very High Very High
Coronary Artery Disease 195 98.40 Very High Very High Very High
INFLAMMATION 379 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of E-selectin is induced in human endothelium in response to cytokines such as interleukin-1 and tumor necrosis factor-?
Positive_regulation (induced) of Gene_expression (expression) of E-selectin in endothelium associated with necrosis, cancer and cytokine
1) Confidence 0.66 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.96 Pain Relevance 0.09
Pretreatment of diclofenac inhibited LPS-induced expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in HUVEC, determined by flow cytometry and a cellular enzyme-linked immunosorbent assay (cell-ELISA).
Spec (determined) Positive_regulation (induced) of Spec (determined) Gene_expression (expression) of E-selectin associated with diclofenac and adhesions
2) Confidence 0.58 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.36 Pain Relevance 0.37
Nicotine has been shown to induce an increase in VCAM-1 mRNA synthesis, but not E-selectin, in primary human coronary artery endothelial cells, but a 1.6 fold elevation required 24 hr exposure to a concentration of nicotine as high as 10-5M (or 1.6 ?
Positive_regulation (increase) of Gene_expression (synthesis) of E-selectin in endothelial cells associated with nicotine
3) Confidence 0.47 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.58 Pain Relevance 0.15
Nicotine has been shown to induce an increase in VCAM-1 mRNA synthesis, but not E-selectin, in primary human coronary artery endothelial cells, but a 1.6 fold elevation required 24 hr exposure to a concentration of nicotine as high as 10-5M (or 1.6 ?
Positive_regulation (increase) of Gene_expression (synthesis) of E-selectin in endothelial cells associated with nicotine
4) Confidence 0.47 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.58 Pain Relevance 0.15
None of the four agents had an effect on TNF-alpha induced E-selectin expression.
Positive_regulation (induced) of Gene_expression (expression) of E-selectin
5) Confidence 0.43 Published 2008 Journal Anesthesiology Section Body Doc Link 18212564 Disease Relevance 0.06 Pain Relevance 0
To begin with, as mentioned above, an elevation in E-selectin levels appears to be a feature of certain groups of patients with CAD, restenosis as well as DM2.
Positive_regulation (elevation) of Gene_expression (levels) of E-selectin associated with coronary artery disease, diabetes mellitus and cardiovascular disease
6) Confidence 0.43 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.53 Pain Relevance 0
Besides, it is still unclear whether the elevation in soluble E-selectin levels in such patients is directly linked to the S128R mutation or not.
Spec (whether) Positive_regulation (elevation) of Gene_expression (levels) of E-selectin
7) Confidence 0.43 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.54 Pain Relevance 0.04
One study involving first degree relatives has indicated that soluble E-selectin levels are elevated in patients with DM2 carrying the 128R allele in comparison with their non-diabetic relatives [10].
Positive_regulation (elevated) of Gene_expression (levels) of E-selectin associated with diabetes mellitus
8) Confidence 0.43 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.60 Pain Relevance 0.09
Kayal and colleagues observed an increase in sICAM-1 and sELAM-1 levels for 3–4 days after study inclusion in non-survivors, sELAM-1 then returning to levels similar to those observed in survivors whereas sICAM-1 continued to increase in non-survivors [10].
Positive_regulation (increase) of Gene_expression (levels) of sELAM-1
9) Confidence 0.39 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 1.11 Pain Relevance 0.04
This study group observed increased levels of sELAM-1 over the study period in patients with sustained organ dysfunction and in non-survivors, whereas sELAM-1 levels decreased in patients whose organ dysfunction resolved [18].
Positive_regulation (increased) of Gene_expression (levels) of sELAM-1
10) Confidence 0.36 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 0.92 Pain Relevance 0.11
In CIP, this may be mediated by the enhanced expression of E-selectin in the vascular endothelium of the peripheral nerves, induced by pro-inflammatory cytokines [61].
Positive_regulation (enhanced) of Gene_expression (expression) of E-selectin in peripheral nerves associated with neuropathy, inflammation and cytokine
11) Confidence 0.27 Published 2008 Journal Crit Care Section Body Doc Link PMC2646339 Disease Relevance 1.74 Pain Relevance 0.20
We demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of Curcuma longa, diferuloylmethane is most potent in inhibiting TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin on human umbilical vein endothelial cells.
Positive_regulation (induced) of Gene_expression (expression) of E-selectin in endothelial cells
12) Confidence 0.24 Published 1999 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 10576620 Disease Relevance 0.25 Pain Relevance 0.17
Circulating plasma levels of P-selectin, E-selectin, and intercellular cell adhesion molecule-1 were elevated in patients with vasospastic angina, indicating an association of endothelial damage and inflammatory reaction with coronary vasospasm.55)56) Hung et al.57) prospectively investigated the association of high-sensitivity C-reactive protein (CRP), a sensitive marker of inflammation, with coronary vasospasm and no hemodynamically significant coronary artery disease in a sample of 428 patients who underwent coronary angiography.
Positive_regulation (elevated) of Spec (investigated) Gene_expression (levels) of E-selectin in coronary artery associated with coronary artery disease, inflammation, cva, coronary vasospasm and adhesions
13) Confidence 0.23 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801457 Disease Relevance 1.42 Pain Relevance 0.47
In 1997, eEPCs were the first putative endothelial progenitors isolated in vitro by culturing CD34+ VEGFR2+ mononuclear blood cells on fibronectin [25] and confirming a subsequent increase in expression of endothelial cell-associated markers such as CD34, CD31, VEGFR2, Tie2, and E-selectin.
Positive_regulation (increase) of Gene_expression (expression) of E-selectin in endothelial cell
14) Confidence 0.15 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.18 Pain Relevance 0.05
A prospective, nested case-control study within the Nurses’ Health Study, has found elevated E-selectin and ICAM-1 levels can predict incident diabetes in logistic regression models conditioned on matching criteria and adjusted for body mass index (BMI), family history of diabetes, smoking, diet score, alcohol intake, activity index and postmenopausal hormone use.
Positive_regulation (elevated) of Gene_expression (levels) of E-selectin in body associated with nicotine addiction, diabetes mellitus, obesity and alcohol
15) Confidence 0.14 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.34 Pain Relevance 0.07
Endothelial p38 activation is known to be important for crucial endothelial functions: chemoattraction by inducing the expression of E-selectin [61], vascular cell adhesion molecule-1 [62] and macrophage chemoattractant protein-1 [63]; angiogenesis by inducing the activation of ETS-1 transcription factor [64], which is overexpressed in the synovial membrane of RA [65] (Fig. 4); and vasodilatation by inducible nitric oxide synthase (iNOS) [66].
Positive_regulation (inducing) of Gene_expression (expression) of E-selectin in macrophage associated with rheumatoid arthritis, increased venous pressure under development and adhesions
16) Confidence 0.14 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 0.70 Pain Relevance 0.15
In our previous study we found that AECA provokes the surface expression of E-selectin and the activation of endothelial cells [11].
Positive_regulation (activation) of Gene_expression (expression) of E-selectin in endothelial cells
17) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.50 Pain Relevance 0.17
promotes the expression of adhesion molecules, such as vascular cell adhesion molecule-1, E-selectin and intercellular adhesion molecule, necessary for the flow of leucocytes into the sub-endothelial tissue [6].
Positive_regulation (promotes) of Gene_expression (expression) of E-selectin in leucocytes associated with adhesions
18) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 1.80 Pain Relevance 0.52
Continual damage to the vascular epithelium results in the development of lesions and these lesions stimulate endothelial adhesion molecule expression, platelet activity and aggregation [119,120].
Positive_regulation (stimulate) of Gene_expression (expression) of endothelial adhesion molecule in epithelium associated with adhesions
19) Confidence 0.11 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 0.85 Pain Relevance 0.22
Both lipopolysaccharide (LPS) and proinflammatory cytokines induce the expression of CD40, vascular adhesion molecule-1 or intercellular adhesion molecule-1, and E-selectin on human brain microvessel endothelial cells [20-24].
Positive_regulation (induce) of Gene_expression (expression) of E-selectin in endothelial cells associated with adhesions and cytokine
20) Confidence 0.10 Published 2005 Journal Crit Care Section Body Doc Link PMC1065096 Disease Relevance 0.85 Pain Relevance 0.33

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