INT62826

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 75
Total Number 78
Disease Relevance 46.39
Pain Relevance 17.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)
Anatomy Link Frequency
endothelial cells 11
lymphocytes 8
neutrophil 8
platelet 5
AMs 4
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1050 100.00 Very High Very High Very High
cytokine 610 100.00 Very High Very High Very High
ischemia 37 100.00 Very High Very High Very High
diclofenac 14 99.98 Very High Very High Very High
aspirin 54 99.84 Very High Very High Very High
Migraine 30 99.84 Very High Very High Very High
chemokine 65 99.80 Very High Very High Very High
agonist 126 99.74 Very High Very High Very High
lidocaine 9 99.64 Very High Very High Very High
dexamethasone 111 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1102 100.00 Very High Very High Very High
Nicotine Addiction 1102 100.00 Very High Very High Very High
Adhesions 818 100.00 Very High Very High Very High
Cv Unclassified Under Development 23 100.00 Very High Very High Very High
Headache 34 99.84 Very High Very High Very High
Cirrhosis 7 99.68 Very High Very High Very High
Skin Cancer 24 99.60 Very High Very High Very High
Rhinitis 405 99.40 Very High Very High Very High
Inflammatory Bowel Disease 359 99.30 Very High Very High Very High
Sepsis 150 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Lidocaine at clinically relevant concentrations decreased neutrophil CD18 and endothelial ICAM-1 expression but not endothelial IL-1beta concentrations.


Negative_regulation (decreased) of Gene_expression (expression) of ICAM-1 in neutrophil
1) Confidence 0.58 Published 2004 Journal Eur J Anaesthesiol Section Body Doc Link 15719860 Disease Relevance 0 Pain Relevance 0
Rezavandi et al. [18] also noted that in histologically normal, non-inflamed periodontal tissues, the percentage of vessels expressing ICAM-1 was reduced in smokers.
Negative_regulation (reduced) of Gene_expression (expressing) of ICAM-1 in vessels associated with nicotine addiction
2) Confidence 0.57 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.26 Pain Relevance 0.12
Rezavandi et al. [18] also noted that in histologically normal, non-inflamed periodontal tissues, the percentage of vessels expressing ICAM-1 was reduced in smokers.
Negative_regulation (reduced) of Gene_expression (expressing) of ICAM-1 in vessels associated with nicotine addiction
3) Confidence 0.57 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.26 Pain Relevance 0.12
Of the platelet aggregation inhibitors tested, only cilostazol significantly attenuated the adhesion through decreasing expression of intercellular adhesion molecule-1 (ICAM-1) and P-selectin.
Negative_regulation (decreasing) of Gene_expression (expression) of intercellular adhesion molecule-1 in platelet
4) Confidence 0.57 Published 2004 Journal Microvasc. Res. Section Body Doc Link 15313121 Disease Relevance 0.16 Pain Relevance 0
Furthermore, a downregulation of the endothelial expression of the adhesion molecules ICAM-1 at the target site and LFA-1 on lymphocytes could also contribute to the absence of inflammatory cells in the neuraxis.
Negative_regulation (downregulation) of Gene_expression (expression) of ICAM-1 in lymphocytes associated with inflammation and adhesions
5) Confidence 0.55 Published 1998 Journal Immunol. Lett. Section Abstract Doc Link 9840682 Disease Relevance 0.92 Pain Relevance 0.39
TNF-alpha-stimulated ICAM-1 expression in HBL cells was also downregulated by sodium salicylate, although in a manner inversely related to the concentration of this agent.
Negative_regulation (downregulated) of Gene_expression (expression) of ICAM-1
6) Confidence 0.55 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.76 Pain Relevance 0.12
Sodium salicylate inhibits TNF-alpha-induced NF-kappaB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells.
Negative_regulation (inhibits) of Gene_expression (expression) of ICAM-1 associated with skin cancer
7) Confidence 0.55 Published 2006 Journal Melanoma Res. Section Title Doc Link 16432451 Disease Relevance 0.76 Pain Relevance 0.04
Lockyer et al. [15] and Gawaz et al. [16] demonstrated that in HUVEC the expression of ICAM-1 can be inhibited via the adding of the inhibitory protein I?
Negative_regulation (inhibited) of Gene_expression (expression) of ICAM-1
8) Confidence 0.54 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.09 Pain Relevance 0
The inhibition of ICAM-1 expression in HUVEC and HCAEC after simultaneous addition of antisense RelA p65 and NF-?
Negative_regulation (inhibition) of Gene_expression (expression) of ICAM-1
9) Confidence 0.54 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.07 Pain Relevance 0
After addition of antisense RelA p65 oligonucleotides to cultures of HCAEC the expression of ICAM-1 was moderately reduced.
Negative_regulation (reduced) of Gene_expression (expression) of ICAM-1
10) Confidence 0.54 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
B1 p50 oligonucleotides the expression of ICAM-1 in HUVEC and HCAEC was inhibited in a dose dependent manner.
Negative_regulation (inhibited) of Gene_expression (expression) of ICAM-1
11) Confidence 0.54 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.09 Pain Relevance 0
ICAM-1 antigen expression, induced on AMs after 24 h of culture, was significantly inhibited by fusafungine in a concentration-dependent manner, as measured by flow cytometry analysis using an anti-CD54 monoclonal antibody.
Negative_regulation (inhibited) of Gene_expression (expression) of ICAM-1 in AMs
12) Confidence 0.53 Published 1998 Journal Transpl. Immunol. Section Abstract Doc Link 9848225 Disease Relevance 0.17 Pain Relevance 0.21
These data demonstrate that diclofenac is capable of inhibiting the expression of E-selectin, ICAM-1 and VCAM-1 in HUVEC.
Negative_regulation (inhibiting) of Gene_expression (expression) of ICAM-1 associated with diclofenac
13) Confidence 0.53 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.31 Pain Relevance 0.36
The ischemia-induced expression of ICAM-1 in HCEC, and the expression/release of IL-8 and MCP-1 in HCEC were abolished by the non-steroid anti-inflammatory drug, indomethacin (100-300 microM).
Negative_regulation (abolished) of Gene_expression (expression) of ICAM-1 in HCEC associated with inflammation and ischemia
14) Confidence 0.52 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 1.14 Pain Relevance 0.58
A sharp decrease in the expression of ICAM-1 (F=5.09, p<0.001 and F=2.46, p<0.05, respectively), sICAM-1 1 (F=6.21, p<0.0001 and F=3.99, p<0.007, respectively) and serum IL-4 (F=6.23, p<0.001 and F=3.64, p<0.01, respectively) were observed in experimentally induced and spontaneous migraine attacks.
Negative_regulation (decrease) of Gene_expression (expression) of ICAM-1 associated with migraine
15) Confidence 0.45 Published 1997 Journal J. Mol. Med. Section Abstract Doc Link 9231885 Disease Relevance 1.12 Pain Relevance 0.85
Fusafungine significantly inhibited rIFN-gamma-induced ICAM-1-protein expression on AMs in a concentration-dependent fashion.
Negative_regulation (inhibited) of Gene_expression (expression) of ICAM-1-protein in AMs
16) Confidence 0.43 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.27 Pain Relevance 0.26
Activated endothelial IL-1beta, IL-6, and IL-8 concentrations and ICAM-1 expression are attenuated only by lidocaine at concentrations larger than clinically relevant concentrations.
Negative_regulation (attenuated) of Gene_expression (expression) of ICAM-1 associated with lidocaine
17) Confidence 0.42 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15673867 Disease Relevance 0.25 Pain Relevance 0.52
It is also a possibility that the reduced level of ICAM-1 expression in normal gingival tissues could reflect ongoing shedding of membrane-bound ICAM-1.
Negative_regulation (reduced) of Gene_expression (expression) of ICAM-1
18) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.14 Pain Relevance 0.12
It is also a possibility that the reduced level of ICAM-1 expression in normal gingival tissues could reflect ongoing shedding of membrane-bound ICAM-1.
Negative_regulation (reduced) of Gene_expression (expression) of ICAM-1
19) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.14 Pain Relevance 0.12
Increased expression of ICAM-1 and VCAM-1 on the dental pulp cells in response to bacterial components was also decreased by treatment with EGCG and ECG.
Negative_regulation (decreased) of Gene_expression (expression) of ICAM-1 in dental pulp
20) Confidence 0.41 Published 2010 Journal Eur. J. Oral Sci. Section Abstract Doc Link 20487003 Disease Relevance 0.53 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox