INT62827

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 184
Total Number 187
Disease Relevance 180.95
Pain Relevance 36.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)
Anatomy Link Frequency
plasma 11
endothelial cells 11
leukocytes 11
monocyte 6
endothelium 6
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3461 100.00 Very High Very High Very High
cytokine 1287 100.00 Very High Very High Very High
chemokine 228 100.00 Very High Very High Very High
qutenza 12 99.98 Very High Very High Very High
Inflammatory response 417 99.92 Very High Very High Very High
Inflammatory mediators 133 99.92 Very High Very High Very High
Neuropeptide 30 99.46 Very High Very High Very High
diclofenac 7 99.44 Very High Very High Very High
substance P 105 99.42 Very High Very High Very High
Angina 230 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 5468 100.00 Very High Very High Very High
INFLAMMATION 4040 100.00 Very High Very High Very High
Myocardial Infarction 225 100.00 Very High Very High Very High
Coagulation Disorder 36 100.00 Very High Very High Very High
Pancreatitis 81 99.96 Very High Very High Very High
Pressure And Volume Under Development 76 99.96 Very High Very High Very High
Nicotine Addiction 9959 99.84 Very High Very High Very High
Pre-eclampsia 185 99.84 Very High Very High Very High
Hypertension 103 99.84 Very High Very High Very High
Adult Respiratory Distress Syndrome 258 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circulating isoforms of ICAM-1 (cICAM-1) are known to be elevated in human serum as an indirect consequence of inflammatory responses.
Positive_regulation (elevated) of ICAM-1 associated with inflammatory response
1) Confidence 0.70 Published 1996 Journal Immunobiology Section Abstract Doc Link 8877397 Disease Relevance 0.60 Pain Relevance 0.18
The addition of SP to HDMEC resulted in a rapid increase in cellular ICAM-1 mRNA levels, followed by a fivefold increase in ICAM-1 cell surface expression.
Positive_regulation (increase) of ICAM-1 associated with substance p
2) Confidence 0.69 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.16 Pain Relevance 0.50
These results indicate that neuropeptides such as SP are capable of directly activating HDMEC to express increased levels of functional ICAM-1 and further support the role of the cutaneous neurological system in modulating inflammatory processes in the skin.
Positive_regulation (increased) of ICAM-1 in skin associated with inflammation, neuropeptide and substance p
3) Confidence 0.69 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.22 Pain Relevance 0.50
Contrary to these reports, Phocas et al. (26) could not detect an increased ICAM-1 serum level in preeclampsia.
Neg (not) Positive_regulation (increased) of ICAM-1 associated with pre-eclampsia
4) Confidence 0.68 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.87 Pain Relevance 0.08
Djurovic et al. (23) also described that concentrations of ICAM-1 were slightly increased in preeclampsia.
Positive_regulation (increased) of ICAM-1 associated with pre-eclampsia
5) Confidence 0.68 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.82 Pain Relevance 0.07
However, Schaberg et al. [93] went on to observe a large increase in ICAM-1, but not P-selectin, E-selectin, or VCAM-1, expression by the endothelium of peripheral pulmonary vessels in smokers, compared to non-smokers.
Positive_regulation (increase) of ICAM-1 in endothelium associated with nicotine addiction
6) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.31 Pain Relevance 0.04
Smoking directly causes an increase in soluble ICAM-1 and specific CD44 variant concentrations in the systemic circulation, diluting several previous diagnostic and prognostic attributions.
Positive_regulation (increase) of ICAM-1 associated with nicotine addiction
7) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.38 Pain Relevance 0
Smoking directly causes an increase in soluble ICAM-1 and specific CD44 variant concentrations in the systemic circulation, diluting several previous diagnostic and prognostic attributions.
Positive_regulation (increase) of ICAM-1 associated with nicotine addiction
8) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.38 Pain Relevance 0
However, Schaberg et al. [93] went on to observe a large increase in ICAM-1, but not P-selectin, E-selectin, or VCAM-1, expression by the endothelium of peripheral pulmonary vessels in smokers, compared to non-smokers.
Positive_regulation (increase) of ICAM-1 in endothelium associated with nicotine addiction
9) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.31 Pain Relevance 0.04
Significant upregulation of membrane-bound ICAM-1 was seen on HUVECs incubated with trypsinated serum.
Positive_regulation (upregulation) of ICAM-1
10) Confidence 0.67 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15308472 Disease Relevance 0.25 Pain Relevance 0
In acute pancreatitis, ICAM-1 is upregulated in various organs and contributes to the development of organ injury.
Positive_regulation (upregulated) of ICAM-1 associated with injury and pancreatitis
11) Confidence 0.67 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15308472 Disease Relevance 0.27 Pain Relevance 0
In conclusion, trypsinated serum induces the upregulation of both membrane-bound ICAM-1 on endothelial cells and soluble ICAM-1.
Positive_regulation (induces) of ICAM-1 in endothelial cells
12) Confidence 0.67 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15308472 Disease Relevance 0.19 Pain Relevance 0
In conclusion, trypsinated serum induces the upregulation of both membrane-bound ICAM-1 on endothelial cells and soluble ICAM-1.
Positive_regulation (upregulation) of ICAM-1 in endothelial cells
13) Confidence 0.67 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15308472 Disease Relevance 0.19 Pain Relevance 0
In the pancreas and lungs of animals infused with trypsin, ICAM-1 and leukocyte sequestration were increased compared with controls.
Positive_regulation (increased) of ICAM-1 in leukocyte
14) Confidence 0.67 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15308472 Disease Relevance 0.22 Pain Relevance 0
The aim of this study was to investigate the effect of the non-steroidal anti-inflammatory agent sodium salicylate on TNF-alpha-induced activation of the transcription factor nuclear factor-kappaB (NF-kappaB) and upregulation of intercellular adhesion molecule-1 (ICAM-1), and TNF-alpha-stimulated cell migration and invasion through fibronectin.
Positive_regulation (upregulation) of ICAM-1 associated with inflammation and adhesions
15) Confidence 0.65 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.69 Pain Relevance 0.05
The aim of this study was to investigate the effect of the non-steroidal anti-inflammatory agent sodium salicylate on TNF-alpha-induced activation of the transcription factor nuclear factor-kappaB (NF-kappaB) and upregulation of intercellular adhesion molecule-1 (ICAM-1), and TNF-alpha-stimulated cell migration and invasion through fibronectin.
Positive_regulation (upregulation) of intercellular adhesion molecule-1 associated with inflammation and adhesions
16) Confidence 0.65 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.69 Pain Relevance 0.05
This is the first report that describes a stressful situation in the endothelial cells created by excess of antioxidative and anti-inflammatory agents NAC and mito-Q, resulting in the generation of reactive oxygen species, carbonylation and glutathionylation of cellular proteins, inhibition of IKKalpha activity, and up-regulation of ICAM-1expression.
Positive_regulation (up-regulation) of ICAM-1expression in endothelial cells associated with inflammation
17) Confidence 0.63 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.40 Pain Relevance 0.12
Diclofenac also inhibited LPS-induced increases in E-selectin, ICAM-1 and VCAM-1 mRNAs, indicating that the action of diclofenac is to inhibit synthesis of these molecules.
Positive_regulation (increases) of ICAM-1 associated with diclofenac
18) Confidence 0.63 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.33 Pain Relevance 0.38
We investigated the induction of adhesion molecules such as L-selectin, E-selectin, ICAM-1, VCAM-1 and Mac-1 on Schwann cells by proinflammatory cytokines.
Spec (investigated) Positive_regulation (nduction ) of ICAM-1 in Schwann cells associated with adhesions and cytokine
19) Confidence 0.61 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10561528 Disease Relevance 0.56 Pain Relevance 0.32
The aim of this study was to investigate whether cICAM-1 levels are elevated in patients with acute pancreatitis within 48 h of the onset of abdominal pain and whether cICAM-1 levels correlate with the severity of the tissue damage.
Spec (whether) Positive_regulation (elevated) of cICAM-1 associated with abdominal pain and pancreatitis
20) Confidence 0.61 Published 1996 Journal Immunobiology Section Abstract Doc Link 8877397 Disease Relevance 0.79 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox