INT62829

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 39
Total Number 41
Disease Relevance 38.42
Pain Relevance 9.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAM1) aging (VCAM1) cell adhesion (VCAM1)
plasma membrane (VCAM1)
Anatomy Link Frequency
leukocyte 4
endothelium 4
plasma 3
skin 3
blood vessels 2
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 8 99.98 Very High Very High Very High
Inflammation 647 99.84 Very High Very High Very High
cytokine 199 99.84 Very High Very High Very High
substance P 48 99.80 Very High Very High Very High
Neuropeptide 18 99.46 Very High Very High Very High
diclofenac 7 99.44 Very High Very High Very High
chemokine 38 98.88 Very High Very High Very High
Central nervous system 36 97.76 Very High Very High Very High
Neuritis 5 97.48 Very High Very High Very High
c fibre 2 91.68 High High
Disease Link Frequency Relevance Heat
Adhesions 884 100.00 Very High Very High Very High
Cirrhosis 92 99.84 Very High Very High Very High
Hypertension 40 99.84 Very High Very High Very High
Inflammatory Bowel Disease 18 99.84 Very High Very High Very High
Adult Respiratory Distress Syndrome 134 99.52 Very High Very High Very High
INFLAMMATION 773 99.48 Very High Very High Very High
Nicotine Addiction 1199 99.32 Very High Very High Very High
Primary Sclerosing Cholangitis 62 99.20 Very High Very High Very High
Otitis Media 134 98.84 Very High Very High Very High
Syndrome 37 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This SP-mediated VCAM-1 induction appeared to be a direct effect that did not require the release of other HDMEC-derived soluble factors.
Positive_regulation (induction) of VCAM-1 associated with substance p
1) Confidence 0.70 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.15 Pain Relevance 0.69
A significant increase in VCAM-1 immunostaining of microvascular endothelium was observed in vivo following capsaicin application to human skin.
Positive_regulation (increase) of VCAM-1 in skin associated with qutenza
2) Confidence 0.70 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.18 Pain Relevance 0.54
Diclofenac also inhibited LPS-induced increases in E-selectin, ICAM-1 and VCAM-1 mRNAs, indicating that the action of diclofenac is to inhibit synthesis of these molecules.
Positive_regulation (increases) of VCAM-1 associated with diclofenac
3) Confidence 0.58 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.33 Pain Relevance 0.38
We investigated the induction of adhesion molecules such as L-selectin, E-selectin, ICAM-1, VCAM-1 and Mac-1 on Schwann cells by proinflammatory cytokines.
Spec (investigated) Positive_regulation (nduction ) of VCAM-1 in Schwann cells associated with adhesions and cytokine
4) Confidence 0.55 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10561528 Disease Relevance 0.56 Pain Relevance 0.32
VCAM-1 is also induced by cytokines, such as IL-1 and mediates the adhesion of mononuclear cells to the endothelium [15-17].
Positive_regulation (induced) of VCAM-1 in endothelium associated with adhesions and cytokine
5) Confidence 0.51 Published 2002 Journal Respir Res Section Body Doc Link PMC150513 Disease Relevance 1.30 Pain Relevance 0.35
A number of the molecules which mediate leukocyte-endothelial adhesion have been identified; these include vascular cellular adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1) and E-selectin (4-6).
Positive_regulation (include) of VCAM-1 in leukocyte associated with adhesions
6) Confidence 0.50 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.08 Pain Relevance 0.12
A number of the molecules which mediate leukocyte-endothelial adhesion have been identified; these include vascular cellular adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1) and E-selectin (4-6).
Positive_regulation (include) of vascular cellular adhesion molecule-1 in leukocyte associated with adhesions
7) Confidence 0.50 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.08 Pain Relevance 0.12
Our results indicate that the topical cutaneous application of the neuropeptide-releasing agent capsaicin resulted in increased ICAM-1 and VCAM-1 immunostaining of microvascular cells in the skin of human volunteers.
Positive_regulation (increased) of VCAM-1 in skin associated with qutenza and neuropeptide
8) Confidence 0.47 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.45 Pain Relevance 0.66
After exposure to SP, DMEC expressed significant levels of both intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), which was accompanied by increased binding to leukocytes expressing the appropriate integrin counter receptors for these CAM.
Positive_regulation (levels) of VCAM-1 in leukocytes associated with adhesions and substance p
9) Confidence 0.47 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.53 Pain Relevance 0.60
Our results indicate that the topical cutaneous application of the neuropeptide-releasing agent capsaicin resulted in increased ICAM-1 and VCAM-1 immunostaining of microvascular cells in the skin of human volunteers.
Positive_regulation (resulted) of VCAM-1 in skin associated with qutenza and neuropeptide
10) Confidence 0.47 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.45 Pain Relevance 0.67
Krauss et al. (9) also found significantly elevated levels of VCAM-1 in the plasma of pregnant women who subsequently developed preeclampsia, 3-15 weeks earlier before the onset of clinical symptoms.
Positive_regulation (elevated) of VCAM-1 in plasma associated with pre-eclampsia
11) Confidence 0.46 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.77 Pain Relevance 0.08
Vascular cell adhesion molecule 1 (VCAM1) was 5.05-fold upregulated in HSC compared to PSC and chemokine (C-C motif) ligand 2 (CCL2) was 2.96-fold upregulated in HSC compared to PSC.
Positive_regulation (upregulated) of Vascular cell adhesion molecule 1 associated with chemokine, cirrhosis, primary sclerosing cholangitis and adhesions
12) Confidence 0.46 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.35 Pain Relevance 0.05
Vascular cell adhesion molecule 1 (VCAM1) was 5.05-fold upregulated in HSC compared to PSC and chemokine (C-C motif) ligand 2 (CCL2) was 2.96-fold upregulated in HSC compared to PSC.
Positive_regulation (upregulated) of VCAM1 associated with chemokine, cirrhosis, primary sclerosing cholangitis and adhesions
13) Confidence 0.46 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.34 Pain Relevance 0.05
Our results indicated that circulating sVCAM-1 levels were significantly increased in severe preeclampsia compared with mild preeclampsia or normal pregnancy.
Positive_regulation (circulating) of sVCAM-1 associated with pre-eclampsia
14) Confidence 0.43 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.82 Pain Relevance 0.09
By using RT-PCR, we demonstrate that it inhibits the induction of steady state transcript levels of ICAM-1, VCAM-1 and E-selectin, and therefore it may interfere with the transcription of their genes.
Positive_regulation (induction) of VCAM-1
15) Confidence 0.41 Published 1999 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 10576620 Disease Relevance 0.23 Pain Relevance 0.17
After exposure to SP, DMEC expressed significant levels of both intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), which was accompanied by increased binding to leukocytes expressing the appropriate integrin counter receptors for these CAM.
Positive_regulation (levels) of vascular cell adhesion molecule-1 in leukocytes associated with adhesions and substance p
16) Confidence 0.41 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.53 Pain Relevance 0.60
Lyall et al. (21) were the first to show that sVCAM-1 was elevated in the serum of preeclamptic patients.
Positive_regulation (elevated) of sVCAM-1
17) Confidence 0.40 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.79 Pain Relevance 0.08
However, Schaberg et al. [93] went on to observe a large increase in ICAM-1, but not P-selectin, E-selectin, or VCAM-1, expression by the endothelium of peripheral pulmonary vessels in smokers, compared to non-smokers.
Positive_regulation (increase) of VCAM-1 in endothelium associated with nicotine addiction
18) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.34 Pain Relevance 0.04
However, Schaberg et al. [93] went on to observe a large increase in ICAM-1, but not P-selectin, E-selectin, or VCAM-1, expression by the endothelium of peripheral pulmonary vessels in smokers, compared to non-smokers.
Positive_regulation (increase) of VCAM-1 in endothelium associated with nicotine addiction
19) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.34 Pain Relevance 0.04
Moreover, Desideri et al. did not demonstrate impaired endothelial function in CSX patients in terms of base-line plasma concentrations of NOx, endothelin-1, and soluble vascular cell adhesion molecule 1 (VCAM-1) (23).
Positive_regulation (soluble) of VCAM-1 in plasma associated with adhesions
20) Confidence 0.39 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852773 Disease Relevance 0.60 Pain Relevance 0.07

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