INT62830

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 149
Total Number 152
Disease Relevance 125.23
Pain Relevance 32.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAM1) aging (VCAM1) cell adhesion (VCAM1)
plasma membrane (VCAM1)
Anatomy Link Frequency
endothelial cells 26
leukocytes 14
lymphocytes 6
macrophages 5
platelets 4
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2113 100.00 Very High Very High Very High
rheumatoid arthritis 1168 100.00 Very High Very High Very High
cytokine 1003 100.00 Very High Very High Very High
chemokine 327 100.00 Very High Very High Very High
qutenza 28 100.00 Very High Very High Very High
substance P 134 99.86 Very High Very High Very High
Neuropeptide 66 99.84 Very High Very High Very High
diclofenac 14 99.54 Very High Very High Very High
antagonist 122 99.52 Very High Very High Very High
Nicotine 80 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2342 100.00 Very High Very High Very High
Adhesions 2165 100.00 Very High Very High Very High
Rheumatoid Arthritis 1188 100.00 Very High Very High Very High
Cirrhosis 286 99.72 Very High Very High Very High
Hyperglycemia 328 99.68 Very High Very High Very High
Focal Cartilage Defect 56 99.68 Very High Very High Very High
Adult Respiratory Distress Syndrome 545 99.66 Very High Very High Very High
Convulsion 90 99.66 Very High Very High Very High
Arthritis 105 99.32 Very High Very High Very High
Increased Venous Pressure Under Development 562 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only substance P (SP) was found to be capable of inducing HDMEC VCAM-1 expression.
Gene_expression (expression) of VCAM-1 associated with substance p
1) Confidence 0.78 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.15 Pain Relevance 0.67
These data indicate that SP is capable of directly and specifically up-regulating functional endothelial VCAM-1 expression and thus may play a key role in modulating certain inflammatory responses in the skin.
Gene_expression (expression) of VCAM-1 in skin associated with inflammatory response and substance p
2) Confidence 0.78 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.10 Pain Relevance 0.60
VCAM-1 expression on human dermal microvascular endothelial cells is directly and specifically up-regulated by substance P.
Gene_expression (expression) of VCAM-1 in endothelial cells associated with qutenza and substance p
3) Confidence 0.78 Published 1999 Journal J. Immunol. Section Title Doc Link 9973426 Disease Relevance 0.18 Pain Relevance 0.63
The expression of VCAM-1 on cells is regulated, at least in part, by multiple microenvironmental influences, such as changes in cytokine concentrations (19).
Gene_expression (expression) of VCAM-1 associated with cytokine
4) Confidence 0.77 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.06 Pain Relevance 0.08
For example, VCAM-1 expression on endothelial cells is induced by interleukin-1?
Gene_expression (expression) of VCAM-1 in endothelial cells
5) Confidence 0.77 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.89 Pain Relevance 0.09
In the present study, we compared the levels of soluble VCAM-1 (sVCAM-1, CD106), ICAM-1 (sICAM-1, CD54) and E-selectin (sE-selectin, CD62E) in the maternal serum of normal and preeclamptic pregnancies.


Gene_expression (levels) of VCAM-1
6) Confidence 0.77 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.09 Pain Relevance 0.03
Similar to VCAM1 expression, CCL2 also showed a HSC specific expression irrespective of the pathology (3.15-fold, p = 0.024, Figure 8E).
Gene_expression (expression) of VCAM1 associated with cirrhosis
7) Confidence 0.76 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.04 Pain Relevance 0.03
All patients showed various degrees of VCAM1 expression.
Gene_expression (expression) of VCAM1
8) Confidence 0.76 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 0.81 Pain Relevance 0.08
After exposure to SP, DMEC expressed significant levels of both intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), which was accompanied by increased binding to leukocytes expressing the appropriate integrin counter receptors for these CAM.
Gene_expression (expressed) of VCAM-1 in leukocytes associated with adhesions and substance p
9) Confidence 0.72 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.53 Pain Relevance 0.61
Vascular cell adhesion molecule 1 expression was only blocked by the inhalational anesthetics and not by morphine.
Gene_expression (expression) of Vascular cell adhesion molecule 1
10) Confidence 0.72 Published 2008 Journal Anesthesiology Section Body Doc Link 18212564 Disease Relevance 0.06 Pain Relevance 0
FACS studies demonstrated a 6.5-fold increase in endothelial cell surface VCAM-1 expression detectable 16 h after addition of SP, which was specifically blocked by a neurokinin-1 receptor antagonist.
Gene_expression (expression) of VCAM-1 in endothelial cell associated with antagonist and substance p
11) Confidence 0.68 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.12 Pain Relevance 0.71
Increased HDMEC VCAM-1 mRNA expression was detected 1 h after the addition of SP, with peak mRNA increase at 6-9 h postinduction.
Gene_expression (expression) of HDMEC VCAM-1 mRNA associated with substance p
12) Confidence 0.68 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.13 Pain Relevance 0.71
We examined the direct effect of cutaneous neuropeptides on the expression and function of human dermal microvascular endothelial cell (HDMEC) VCAM-1.
Gene_expression (expression) of VCAM-1 in endothelial cell associated with neuropeptide
13) Confidence 0.68 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.18 Pain Relevance 0.53
Extravasation of particular subsets of leukocytes depends upon the regulated expression of cellular adhesion molecules such as VCAM-1 on microvascular endothelial cells.
Gene_expression (expression) of VCAM-1 in leukocytes associated with adhesions
14) Confidence 0.68 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.19 Pain Relevance 0.45
Likewise, the constitutively low expression of ICAM-1 and VCAM-1 is rapidly upregulated on the cytokine-activated cerebrovascular ECs facilitating adhesion and transmigration of leukocytes into the CNS [35,66,67].
Gene_expression (expression) of VCAM-1 in leukocytes associated with adhesions and cytokine
15) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.69 Pain Relevance 0.13
In contrast to these reports, Haller et al. (22) reported that ICAM-1 expression was increased in serum from preeclamptic patients but VCAM-1 expression was not.
Gene_expression (expression) of VCAM-1
16) Confidence 0.67 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.62 Pain Relevance 0.07
In the present study, we compared the levels of soluble VCAM-1 (sVCAM-1, CD106), ICAM-1 (sICAM-1, CD54) and E-selectin (sE-selectin, CD62E) in the maternal serum of normal and preeclamptic pregnancies.


Gene_expression (levels) of sVCAM-1
17) Confidence 0.67 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.09 Pain Relevance 0.03
Liver cirrhosis tissues were probed with alpha-smooth muscle actin (Figure 8A) or VCAM-1 (Figure 8B).
Gene_expression (probed) of VCAM-1 in smooth muscle associated with cirrhosis
18) Confidence 0.66 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.08 Pain Relevance 0.06
In addition to stellate cells, pancreatic cancer cells, hepatocytes and some inflammatory cells were also positive for VCAM1 (Figure 7C-H).


Gene_expression (positive) of VCAM1 in hepatocytes associated with inflammation and pancreatic cancer
19) Confidence 0.66 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 0.87 Pain Relevance 0.09
The results of the present study suggest that the anti-atherogenic effect of hematein is not related to control of the plasma lipid profile but probably related to the inhibition of VCAM-1 and MCP-1 expression resulting in an amelioration of lesion development in the rabbit.
Gene_expression (expression) of VCAM-1 in plasma
20) Confidence 0.65 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11689202 Disease Relevance 0.31 Pain Relevance 0

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