INT62831

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.63
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELE) cell adhesion (SELE) plasma membrane (SELE)
SELE (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 7 99.88 Very High Very High Very High
Inflammatory response 3 95.12 Very High Very High Very High
cytokine 6 90.56 High High
cINOD 2 82.08 Quite High
Inflammation 10 78.84 Quite High
ischemia 8 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Inflammatory Response Syndrome 3 95.48 Very High Very High Very High
Adhesions 22 90.92 High High
Sepsis 67 89.92 High High
INFLAMMATION 12 81.84 Quite High
Disease 4 73.68 Quite High
Critical Illness 2 64.72 Quite High
Shock 3 51.20 Quite High
Injury 2 7.12 Low Low
Coronary Artery Disease 9 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diclofenac also inhibited LPS-induced increases in E-selectin, ICAM-1 and VCAM-1 mRNAs, indicating that the action of diclofenac is to inhibit synthesis of these molecules.
Negative_regulation (inhibited) of Positive_regulation (increases) of E-selectin associated with diclofenac
1) Confidence 0.36 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.33 Pain Relevance 0.38
This study group observed increased levels of sELAM-1 over the study period in patients with sustained organ dysfunction and in non-survivors, whereas sELAM-1 levels decreased in patients whose organ dysfunction resolved [18].
Negative_regulation (decreased) of Positive_regulation (increased) of sELAM-1
2) Confidence 0.33 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 1.06 Pain Relevance 0.14
By using RT-PCR, we demonstrate that it inhibits the induction of steady state transcript levels of ICAM-1, VCAM-1 and E-selectin, and therefore it may interfere with the transcription of their genes.
Negative_regulation (inhibits) of Positive_regulation (induction) of E-selectin
3) Confidence 0.20 Published 1999 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 10576620 Disease Relevance 0.24 Pain Relevance 0.17

General Comments

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