INT62832

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 10.60
Pain Relevance 5.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELE) cell adhesion (SELE) plasma membrane (SELE)
Anatomy Link Frequency
endothelial cells 10
leukocytes 2
embryonic stem cells 2
synovium 2
SELE (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 21 100.00 Very High Very High Very High
Inflammatory response 8 100.00 Very High Very High Very High
abatacept 119 99.98 Very High Very High Very High
diclofenac 14 99.98 Very High Very High Very High
fibrosis 3 99.92 Very High Very High Very High
Arthritis 130 99.84 Very High Very High Very High
dexamethasone 18 99.82 Very High Very High Very High
methotrexate 27 99.70 Very High Very High Very High
rheumatoid arthritis 81 98.08 Very High Very High Very High
Inflammation 127 93.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 143 100.00 Very High Very High Very High
Adhesions 29 100.00 Very High Very High Very High
Fibrosis 2 99.92 Very High Very High Very High
Seronegative Spondarthritis 73 99.84 Very High Very High Very High
Death 25 99.08 Very High Very High Very High
Rheumatoid Arthritis 83 98.08 Very High Very High Very High
Pulmonary Hypertension 9 94.24 High High
Reperfusion Injury 3 94.12 High High
Contact Dermatitis 28 93.84 High High
Cv Unclassified Under Development 5 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of diclofenac inhibited LPS-induced expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in HUVEC, determined by flow cytometry and a cellular enzyme-linked immunosorbent assay (cell-ELISA).
Negative_regulation (inhibited) of Spec (determined) Gene_expression (expression) of E-selectin associated with diclofenac and adhesions
1) Confidence 0.49 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.36 Pain Relevance 0.37
Importantly, Dex is able to increase the expression of MKP-1, which causes an inactivation of TNF-alpha-induced p38 MAPK and mediates inhibition of E-selectin expression.
Negative_regulation (inhibition) of Gene_expression (expression) of E-selectin associated with dexamethasone
2) Confidence 0.44 Published 2007 Journal FASEB J. Section Abstract Doc Link 17099067 Disease Relevance 0.46 Pain Relevance 0.52
This investigation sought to determine whether systemic radionuclide therapy decreases the production of cell adhesion molecules (E-selectins) that participate in the metastatic process.
Spec (whether) Negative_regulation (decreases) of Gene_expression (production) of E-selectin associated with adhesions
3) Confidence 0.42 Published 2000 Journal J. Nucl. Med. Section Abstract Doc Link 10855628 Disease Relevance 0.43 Pain Relevance 0.25
These data demonstrate that diclofenac is capable of inhibiting the expression of E-selectin, ICAM-1 and VCAM-1 in HUVEC.
Negative_regulation (inhibiting) of Gene_expression (expression) of E-selectin associated with diclofenac
4) Confidence 0.36 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.31 Pain Relevance 0.36
In endothelial MKP-1(-/-) cells differentiated from MKP-1(-/-) embryonic stem cells and in MKP-1-silenced human endothelial cells, Dex did not inhibit TNF-alpha-evoked E-selectin expression.
Negative_regulation (inhibit) of Gene_expression (expression) of E-selectin in embryonic stem cells associated with dexamethasone
5) Confidence 0.32 Published 2007 Journal FASEB J. Section Abstract Doc Link 17099067 Disease Relevance 0.45 Pain Relevance 0.50
Here, we communicate that Dex at low concentrations (1-100 nM) markedly attenuates E-selectin expression without affecting NF-kappaB.
Negative_regulation (attenuates) of Gene_expression (expression) of E-selectin associated with dexamethasone
6) Confidence 0.32 Published 2007 Journal FASEB J. Section Abstract Doc Link 17099067 Disease Relevance 0.48 Pain Relevance 0.52
We demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of Curcuma longa, diferuloylmethane is most potent in inhibiting TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin on human umbilical vein endothelial cells.
Negative_regulation (inhibiting) of Gene_expression (expression) of E-selectin in endothelial cells
7) Confidence 0.20 Published 1999 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 10576620 Disease Relevance 0.25 Pain Relevance 0.17
NHE inhibition decreased also the IL-1beta-induced HUVEC inflammatory response, because amiloride suppressed IL-1beta-induced E-selectin expression on HUVECs.
Negative_regulation (suppressed) of Gene_expression (expression) of E-selectin associated with inflammatory response
8) Confidence 0.19 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12107048 Disease Relevance 0.43 Pain Relevance 0.35
E-selectin expression is also markedly reduced in PsA and, while interleukin-2 is absent from RA synovium, it is detectable in PsA synovium [46].
Negative_regulation (reduced) of Gene_expression (expression) of E-selectin in synovium associated with rheumatoid arthritis and arthritis
9) Confidence 0.17 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 1.43 Pain Relevance 0.64
plus methotrexate significantly decreases serum IL-18, E-selectin, TIMP1 and MMP9 levels [53].
Negative_regulation (decreases) of Gene_expression (levels) of E-selectin associated with methotrexate
10) Confidence 0.16 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.54 Pain Relevance 0.22
In addition to inhibition of DNA synthesis in lymphocytes, depletion of guanosine nucleotides suppresses the expression of several adhesion receptors including vascular cell adhesion molecule 1 (VCAM-1), E-selectin, and P-selectin on vascular endothelial cells.9 This interferes with the attachment of leukocytes to endothelial cells and prevents the recruitment of lymphocytes and monocytes to sites of inflammation.10,11 Suppression of mononuclear cell recruitment is another mechanism by which MMF decreases acute and chronic graft rejection.
Negative_regulation (suppresses) of Gene_expression (expression) of E-selectin in leukocytes associated with inflammation, graft vs host disease and adhesions
11) Confidence 0.15 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.38 Pain Relevance 0.08
Olive oil phenolic compounds have been shown to inhibit endothelial adhesion molecule expression upon incubation with human umbilical vein endothelial cells [27].
Negative_regulation (inhibit) of Gene_expression (expression) of endothelial adhesion molecule in endothelial cells associated with adhesions
12) Confidence 0.13 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 0.60 Pain Relevance 0.13
/LPS activation and partially reduced E-selectin expression.
Negative_regulation (reduced) of Gene_expression (expression) of E-selectin
13) Confidence 0.13 Published 2008 Journal Gut Section Body Doc Link PMC2582343 Disease Relevance 0.44 Pain Relevance 0.12
Butein has also been shown to have multiple other activities, including inhibition of epidermal growth factor receptors [17], tyrosine kinase inhibition [18], suppression of E-selectin expression [19], inhibition of tyrosinase enzymes [20], and inhibition of cyclooxygenase-2 [21].
Negative_regulation (suppression) of Gene_expression (expression) of E-selectin
14) Confidence 0.12 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC554991 Disease Relevance 1.02 Pain Relevance 0
In our previous study we found that AECA provokes the surface expression of E-selectin and the activation of endothelial cells [11].
Negative_regulation (provokes) of Gene_expression (expression) of E-selectin in endothelial cells
15) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.51 Pain Relevance 0.17
In addition to the expression of E-selectin, CCL17, CXCL16, CX3CL1, and increased numbers of integrin ligands [33-35], we show here for the first time a very early production of CS-1 fibronectin by activated endothelial cells in patients with ACD.
Negative_regulation (numbers) of Gene_expression (expression) of E-selectin in endothelial cells associated with contact dermatitis
16) Confidence 0.07 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.09 Pain Relevance 0
At the doses of 2 mg/kg or 10 mg/kg used in further clinical studies, abatacept decreased serum levels of proinflammatory cytokines and inflammatory responses, including soluble IL-2 receptor, IL-6, E-selectin, TNF-alfa, rheumatoid factor, and C-reactive protein levels (Weisman et al. 2006).
Negative_regulation (decreased) of Gene_expression (levels) of E-selectin associated with inflammatory response, abatacept and cytokine
17) Confidence 0.06 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012435 Disease Relevance 0.54 Pain Relevance 0.65
Protection afforded by low temperature may be linked to a wide variety of effects, including reduction of ATP store depletion, inhibition of endothelial cell expression of E-selectin, modification of cell death signaling pathways, and preservation of gene expression for mitochondrial proteins [16].
Negative_regulation (inhibition) of Gene_expression (expression) of E-selectin in endothelial cell associated with death
18) Confidence 0.04 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 0.80 Pain Relevance 0.05

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