INT62835

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Context Info
Confidence 0.47
First Reported 1996
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 2.00
Pain Relevance 5.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1F) signal transducer activity (HTR1F)
Anatomy Link Frequency
brain 3
plasma 1
HTR1F (Homo sapiens)
Pain Link Frequency Relevance Heat
Sumatriptan 38 99.98 Very High Very High Very High
antagonist 6 99.60 Very High Very High Very High
Migraine 15 96.56 Very High Very High Very High
Potency 11 96.42 Very High Very High Very High
agonist 15 94.52 High High
fifth nerve 2 92.48 High High
Hippocampus 2 90.20 High High
Triptan 2 89.52 High High
Substantia nigra 5 87.48 High High
monoamine 1 84.36 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 1 98.96 Very High Very High Very High
Migraine Disorders 2 96.56 Very High Very High Very High
Cluster Headache 4 93.52 High High
Vomiting 2 92.68 High High
Headache 13 90.20 High High
Urological Neuroanatomy 3 89.56 High High
Phobia 1 83.48 Quite High
Anxiety Disorder 1 82.88 Quite High
Increased Venous Pressure Under Development 4 82.72 Quite High
Depression 1 80.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory potency of the drugs was significantly correlated with their affinity for 5-HTID receptors in human brain and for cloned human 5-HT1D alpha and 5-HT1D beta receptors, but not with their affinity for 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT5B and 5-HT7 receptors.
5-HT1F Neg (not) Binding (affinity) of in brain associated with potency
1) Confidence 0.47 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.48
Most of them also show affinity for 5-ht1F binding sites and have better oral pharmacokinetics than sumatriptan.
5-ht1F Binding (affinity) of associated with sumatriptan
2) Confidence 0.47 Published 1999 Journal Clin Neuropharmacol Section Abstract Doc Link 10367177 Disease Relevance 0.57 Pain Relevance 0.98
Human 5-HT1F receptor-stimulated [35S]GTPgammaS binding: correlation with inhibition of guinea pig dural plasma protein extravasation.
5-HT1F Binding (binding) of in plasma
3) Confidence 0.47 Published 1998 Journal Eur. J. Pharmacol. Section Title Doc Link 9718276 Disease Relevance 0.09 Pain Relevance 0.39
In the course of these studies, it was found that the purportedly selective 5-HT1D receptor antagonist GR127935 inhibited 5-HT1F receptor-stimulated [35S]GTPgammaS binding with a Ki of 39.6 +/- 9.5 nM.
5-HT1F Binding (binding) of associated with antagonist
4) Confidence 0.47 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9718276 Disease Relevance 0.06 Pain Relevance 0.36
Alniditan showed moderate-to-low or no affinity for other investigated receptors; sumatriptan showed additional binding to 5-HT1F receptors.
5-HT1F Binding (binding) of associated with sumatriptan
5) Confidence 0.47 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8967979 Disease Relevance 0.14 Pain Relevance 0.78
This distribution of [3H]sumatriptan-binding sites in the human brain shows some differences when compared with that of 5HT1D receptors, confirming that, besides 5HT1D, sumatriptan also binds to 5HT1F receptor subtype.
5HT1F Binding (binds) of in brain associated with sumatriptan
6) Confidence 0.47 Published 1996 Journal Cephalalgia Section Abstract Doc Link 8869766 Disease Relevance 0.15 Pain Relevance 0.77
In the human brain sumatriptan binds to at least two 5-HT1 receptors, 5-HT1D and 5-HT1F.
5-HT1F Binding (binds) of in brain associated with sumatriptan
7) Confidence 0.47 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8720594 Disease Relevance 0.09 Pain Relevance 0.58
Compounds interacting with 5-HT1F, 5-HT2C, 5-HT6 and 5-HT7 receptors are currently under investigation and may prove to have important therapeutic applications in the future.
5-HT1F Binding (interacting) of
8) Confidence 0.47 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11888547 Disease Relevance 0.60 Pain Relevance 0.26
Eletriptan, like sumatriptan, zolmitriptan, naratriptan and rizatriptan had highest affinity for the human 5-HT1B, 5-HT1D and putative 5-ht1f receptor.
5-ht1f Binding (affinity) of associated with sumatriptan
9) Confidence 0.36 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10193663 Disease Relevance 0.10 Pain Relevance 0.47
F 11356 has subnanomolar affinity for cloned human and nonhuman 5-HT1B and 5-HT1D receptors, and its affinity for 5-HT1A and other 5-HT receptors, including the 5-ht1F subtype, is 50-fold lower and micromolar, respectively.
5-ht1F Binding (affinity) of
10) Confidence 0.36 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10381763 Disease Relevance 0.13 Pain Relevance 0.15
Isolated microvessels and capillaries consistently expressed messages for the h5-HT1B, h5-HT1D, 5-HT1F, 5-HT2A but not 5-HT7 receptors.
5-HT1F Binding (messages) of
11) Confidence 0.36 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0
Since a number of drugs display high affinity for the 5-HT1D (GR127935) and 5-HT1F (e.g. methysergide and oxymetazoline) receptor subtypes, in this study we have used these drugs to determine whether the above vasoconstrictor 5-HT1-like receptors correlate with the 5-HT1D and/or 5-HT1F receptor subtypes.
5-HT1F Binding (affinity) of
12) Confidence 0.35 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8938651 Disease Relevance 0.07 Pain Relevance 0.20

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