INT62861

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Context Info
Confidence 0.60
First Reported 1995
Last Reported 2010
Negated 5
Speculated 5
Reported most in Body
Documents 45
Total Number 51
Disease Relevance 13.35
Pain Relevance 16.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
spinal 7
neurons 4
spinal cord 2
hippocampus 2
entopeduncular nucleus 1
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 289 100.00 Very High Very High Very High
Analgesic 42 100.00 Very High Very High Very High
nociceptor 7 100.00 Very High Very High Very High
intrathecal 2 100.00 Very High Very High Very High
antagonist 42 99.96 Very High Very High Very High
nMDA receptor 302 99.80 Very High Very High Very High
tetrodotoxin 9 99.72 Very High Very High Very High
antidepressant 6 99.68 Very High Very High Very High
agonist 35 99.56 Very High Very High Very High
Pain 236 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 510 99.90 Very High Very High Very High
Thiamine Deficiency 124 99.82 Very High Very High Very High
Injury 62 99.80 Very High Very High Very High
Nociception 560 99.44 Very High Very High Very High
Inflammatory Pain 190 99.36 Very High Very High Very High
Hypersensitivity 58 98.88 Very High Very High Very High
Anxiety Disorder 205 98.76 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

20 98.40 Very High Very High Very High
Depression 219 98.20 Very High Very High Very High
Convulsion 48 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several studies suggest that these receptor subunits may play distinct roles in the regulation of AMPA receptor trafficking and synaptic plasticity.
Regulation (regulation) of AMPA
1) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.50
In spinal neurons, accumulating evidence supports the important role of the regulation of AMPA receptors by phosphorylation in spinal nociceptive process.
Regulation (regulation) of AMPA in spinal associated with nociception
2) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.21 Pain Relevance 0.29
Studies may suggest a critical role of Stargazin in the regulation of AMPA receptor trafficking from extra-synaptic to synaptic sites, thus it leads to the controllable events of AMPA receptor-PSD-95 complex [56].
Regulation (regulation) of AMPA receptor
3) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.11
Interestingly, several studies have shown that the trafficking of AMPA receptors, their subunits composition, phosphorylation regulation of AMPA receptor subunits, and interacting proteins also play an important role in the nociceptive processing of the spinal cord.
Regulation (regulation) of AMPA receptor in spinal cord associated with nociception and spinal cord
4) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.41 Pain Relevance 0.43
All the data demonstrated that the regulation of the spinal AMPA receptors in postsynaptic membranes through the receptor trafficking may play a remarkable role in the AMPA receptor-mediated nociception.


Regulation (regulation) of AMPA in postsynaptic membranes associated with nociception
5) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.43 Pain Relevance 0.44
It has been demonstrated that the regulation of AMPA receptor cycling and surface trafficking plays a critical role in the induction of LTP in hippocampal neurons [21].
Regulation (regulation) of AMPA receptor in neurons
6) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.19 Pain Relevance 0.43
This review will bring together recent advances in understanding the molecular mechanisms of spinal AMPA receptor regulation and their implications in nociception.


Regulation (regulation) of AMPA receptor in spinal associated with nociception
7) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.26 Pain Relevance 0.38
In contrast to the wealth of information on the regulation of the AMPA receptor trafficking in hippocampal neurons, much less is known about its trafficking events in spinal nociceptive neurons following painful stimuli.
Regulation (regulation) of AMPA receptor in neurons associated with nociception and pain
8) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.28 Pain Relevance 0.45
Because AMPA receptor complexes that lack the GluR2 subunit are relatively insensitive to pentobarbital inhibition, GluR2 null mutant mice provide a novel tool to investigate the importance of AMPA receptor inhibition to the anesthetic effects of barbiturates.
Spec (investigate) Regulation (importance) of AMPA receptor
9) Confidence 0.44 Published 1999 Journal Anesthesiology Section Abstract Doc Link 10551584 Disease Relevance 0 Pain Relevance 0.27
These results suggest that the GluA1 and GluA2 subunits differently modulate synaptic plasticity in the SSC, consistent with the ACC.


Regulation (modulate) of GluA2 associated with somatosensory cortex and anterior cingulate cortex
10) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.38 Pain Relevance 0.59
It has been showed that an over-expression of Stargazin increases the number of extra-synaptic AMPA receptors without affecting AMPA receptor-mediated synaptic transmission.
Neg (without) Regulation (affecting) of AMPA receptor
11) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.13
The trafficking of AMPA receptors has been well studied in glutamatergic neurons of hippocampus.
Regulation (trafficking) of AMPA in hippocampus associated with hippocampus
12) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.09 Pain Relevance 0.47
Interestingly, several studies have shown that the trafficking of AMPA receptors, their subunits composition, phosphorylation regulation of AMPA receptor subunits, and interacting proteins also play an important role in the nociceptive processing of the spinal cord.
Regulation (trafficking) of AMPA in spinal cord associated with nociception and spinal cord
13) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.42 Pain Relevance 0.49
A number of studies have characterized the effects of GluR2 deletion on synaptic transmission in the hippocampus [16], [17].
Regulation (effects) of GluR2 in hippocampus associated with hippocampus
14) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.24 Pain Relevance 0.29
TD did not alter either the protein or mRNA levels of GluR2 (Figure 2B and 2C).
Neg (not) Regulation (alter) of GluR2 associated with thiamine deficiency
15) Confidence 0.33 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.49 Pain Relevance 0.13
Phosphorylation and dephosphorylation of GluR1 play a critical role for AMPA receptor insertion and internalization [9], [12], thereby affecting AMPA receptor-mediated synaptic responses.
Regulation (affecting) of AMPA
16) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.42 Pain Relevance 0.07
2 may shift the generation of tetramer AMPA receptors toward the formation of nonfunctional GluR?
Regulation (generation) of AMPA
17) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0 Pain Relevance 0.03
We hypothesized that the coupling existed at the transcriptional level by having the same transcription factor to regulate a marker of energy metabolism, cytochrome c oxidase (COX) and an important subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors, GluR2 (Gria2).
Regulation (regulate) of GluR2 associated with glutamate receptor
18) Confidence 0.25 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19166514 Disease Relevance 0 Pain Relevance 0.15
Silencing of NRF-1 with small interference RNA prevented the depolarization-stimulated up-regulation of Gria2 and COX, and over-expression of NRF-1 rescued neurons from tetrodotoxin-induced down-regulation of Gria2 and COX transcripts.
Regulation (regulation) of Gria2 in neurons associated with tetrodotoxin
19) Confidence 0.25 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19166514 Disease Relevance 0 Pain Relevance 0.18
Functional regulation of spinal AMPA receptors through the composition switch of its subunits
Regulation (regulation) of AMPA in spinal
20) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.29 Pain Relevance 0.32

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