INT62868

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.37
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
keratinocytes 1
midguts 1
Ifna (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 1 99.36 Very High Very High Very High
Opioid 1 98.44 Very High Very High Very High
analgesia 1 97.76 Very High Very High Very High
cytokine 26 97.72 Very High Very High Very High
tolerance 18 93.72 High High
backache 1 51.48 Quite High
Potency 14 32.24 Quite Low
anesthesia 1 25.00 Low Low
ketamine 1 11.80 Low Low
Pain 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 58 99.68 Very High Very High Very High
Sarcoma 83 99.28 Very High Very High Very High
Stress 2 99.20 Very High Very High Very High
Htlv Types I And Ii 5 98.60 Very High Very High Very High
Splenomegaly 4 98.40 Very High Very High Very High
Abscess 20 98.04 Very High Very High Very High
Rickettsiaceae Infection 50 97.76 Very High Very High Very High
Infection 83 97.12 Very High Very High Very High
Cancer 161 94.48 High High
Necrosis 1 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An introduction to the IFNA, its objectives and relationships.
Gene_expression (introduction) of IFNA
1) Confidence 0.67 Published 1998 Journal World Hosp Health Serv Section Abstract Doc Link 10185180 Disease Relevance 0 Pain Relevance 0
cytokine inhibitor’ theory has been planned, which proposes a possible interference of contact allergens with the pre-existing proinflammatory cytokines and also their continued production by follicular keratinocytes.[2] The other events noted are a decrease in the raised interferon ?
Gene_expression (raised) of interferon in keratinocytes associated with cytokine
2) Confidence 0.65 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002409 Disease Relevance 0.49 Pain Relevance 0.10
Our findings reviewed in this article have revealed that the stimulation of opioid receptors of the hypothalamic neurons by interferon alpha and beta-endorphin synthesized in the brain or by stress causing the opioid-dependent analgesia suppresses the natural killer cytotoxicity, an important component of immunosurveillance, through an activation of the hypothalamic CRF-sympathetic nervous system.
Gene_expression (synthesized) of interferon alpha in neurons associated with stress, opioid receptor, opioid and analgesia
3) Confidence 0.63 Published 1995 Journal Neurobiology (Bp) Section Abstract Doc Link 8696299 Disease Relevance 0.10 Pain Relevance 0.25
B:9-23/IFA-induced IFN?
Gene_expression (/) of IFA
4) Confidence 0.29 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.38 Pain Relevance 0.12
g of HPV16 E7 peptide emulsified in 1:1 PBS:IFA mixture and boosted two weeks later with another 100 ?
Gene_expression (mixture) of IFA
5) Confidence 0.18 Published 2006 Journal J Transl Med Section Body Doc Link PMC1630705 Disease Relevance 0.16 Pain Relevance 0
g of HPV16 E7 peptide emulsified in 1:1 PBS:IFA mixture.
Gene_expression (mixture) of IFA
6) Confidence 0.18 Published 2006 Journal J Transl Med Section Body Doc Link PMC1630705 Disease Relevance 0.18 Pain Relevance 0
Incomplete Freund's Adjuvant (IFA) preparation
Gene_expression (preparation) of IFA
7) Confidence 0.15 Published 2008 Journal J Transl Med Section Body Doc Link PMC2430193 Disease Relevance 0.38 Pain Relevance 0
Interferon-alpha, pentostatin, and cladribine have been introduced consecutively in the treatment of HCL, and the last named is now accepted as the standard of care (Golomb et al 1987; Spiers et al 1987; Piro et al 1990; Grever et al 1995; Rai et al 1995).
Gene_expression (introduced) of Interferon-alpha associated with htlv types i and ii
8) Confidence 0.08 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727901 Disease Relevance 1.23 Pain Relevance 0
For aggressive KS, several treatment options are now available, including conventional chemotherapies (eg, ABV, BV, CHOP), interferon alpha, vinca alkaloids, taxanes, and liposomal anthracyclines (reviewed in Krown et al 2004).
Gene_expression (available) of interferon alpha associated with sarcoma
9) Confidence 0.07 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676651 Disease Relevance 0.38 Pain Relevance 0.05
With improvements in recent generations of IFA products that have more specific surfactants and refined oils that reduce the frequency of local and systemic adverse events, the use of these potent water-in-oil adjuvant formulations was adopted for immunotherapeutic vaccines for fatal diseases including HIV-1 infection.
Gene_expression (products) of IFA associated with acquired immune deficiency syndrome or hiv infection, disease and infection
10) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919382 Disease Relevance 0.78 Pain Relevance 0
There was some discrepancy between IFA positivity and the results of Western blot analysis.
Gene_expression (positivity) of IFA
11) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2204057 Disease Relevance 0.07 Pain Relevance 0
The statistical significance of the effect of combined vaccine delivery was determined using a Mann-Whitney U test to compare ELISA and IFA titres between the two vaccination groups.
Gene_expression (titres) of IFA
12) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2204057 Disease Relevance 0.17 Pain Relevance 0
Murine typhus convalescent-phase serum, R.typhi-positive opossum serum, negative control serum, and uninfected flea midguts (IFA and PCR negative) were used as positive and negative controls.
Neg (negative) Gene_expression (negative) of IFA in midguts associated with rickettsiaceae infection
13) Confidence 0.04 Published 2002 Journal Emerging Infectious Diseases Section Body Doc Link PMC2737805 Disease Relevance 0.24 Pain Relevance 0
IFA (EUROIMMUN) and in-house MAC-ELISA detected IgM on 4.88 day and 4.38 day respectively.
Gene_expression (detected) of IFA
14) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2907414 Disease Relevance 0.31 Pain Relevance 0
Using IFA (EUROIMMUN) and MAC-ELISA (A226) on the panel collected from the second outbreak, the average day of IgM detection was 4.86 after fever onset.
Gene_expression (Using) of IFA associated with fever
15) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2907414 Disease Relevance 0.51 Pain Relevance 0

General Comments

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