INT62872

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Context Info
Confidence 0.14
First Reported 1996
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.05
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymph node 1
MALT 1
T-cell 1
Igh (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 5 90.04 High High
anesthesia 1 87.04 High High
Central nervous system 4 84.52 Quite High
Inflammation 4 81.96 Quite High
chemokine 15 55.36 Quite High
rheumatoid arthritis 3 30.12 Quite Low
corticosteroid 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 366 98.80 Very High Very High Very High
Diffuse Large B-cell Lymphoma 168 96.72 Very High Very High Very High
Genetic Translocation 3 90.72 High High
Demyelinating Disease 7 90.04 High High
Syndrome 18 85.92 High High
Chronic Lymphoid Leukemia 12 85.56 High High
Salivary Gland Disease 6 83.88 Quite High
Malignant Neoplastic Disease 24 82.64 Quite High
INFLAMMATION 4 81.96 Quite High
Cancer 123 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
3) but remained unknown in the remaining 18 cases. t(14;18)/IGH-BCL2, t(14;18)/IGH-MALT1, and t(1;14)/BCL10-IGH were not detected in any case. t(11;18)/API2-MALT1 was detected in none of the cases, except for one case of DLBCL with MALT lymphoma, which showed positive signals only in MALT lymphoma cells.
Neg (not) Gene_expression (detected) of IGH in MALT associated with lymphatic system cancer and diffuse large b-cell lymphoma
1) Confidence 0.14 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.39 Pain Relevance 0
Translocations involving IGH were detected in 36 (32%) of 111 cases; their partner genes included BCL6 (n?
Gene_expression (involving) of IGH
2) Confidence 0.14 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.67 Pain Relevance 0.03
Sixty-three percent of the lymph node cases contained mutated IgH genes and 49% of the lymph node cases were ZAP-70-positive, and a significant correlation was observed between ZAP-70 expression and IgH mutation status.
Gene_expression (expression) of IgH in lymph node
3) Confidence 0.12 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.35 Pain Relevance 0
Association and/or linkage studies to candidate genes have produced many reports of significant genetic effects including those for the major histocompatability complex (MHC; particularly the HLA-DR2 allele), immunoglobulin heavy chain (IgH), T-cell receptor (TCR) and myelin basic protein (MBP) loci.
Gene_expression (produced) of immunoglobulin heavy chain in T-cell
4) Confidence 0.04 Published 1996 Journal Nat. Genet. Section Abstract Doc Link 8696344 Disease Relevance 0.64 Pain Relevance 0.37

General Comments

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