INT62881

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HTR4) plasma membrane (HTR4) cytoplasm (HTR4)
signal transducer activity (HTR4)
Anatomy Link Frequency
enterocytes 2
HTR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
spastic colon 6 99.08 Very High Very High Very High
Serotonin 1 92.08 High High
agonist 2 90.32 High High
abdominal pain 2 84.08 Quite High
Clonidine 1 47.92 Quite Low
headache 1 39.68 Quite Low
antagonist 1 29.76 Quite Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 99.08 Very High Very High Very High
Functional Bowel Disorder 2 98.88 Very High Very High Very High
Constipation 5 97.40 Very High Very High Very High
Disease 1 91.36 High High
Abdominal Pain 2 84.08 Quite High
Diarrhoea 2 43.60 Quite Low
Flatulence 1 40.64 Quite Low
Headache 1 39.68 Quite Low
Vomiting 1 38.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Their prokinetic effect is thought to be due to the augmentation of acetylcholine release from the myenteric plexus, an effect likely to be mediated through the stimulation of 5-HT4 receptors.
Positive_regulation (mediated) of Positive_regulation (stimulation) of 5-HT4
1) Confidence 0.49 Published 1996 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 8697180 Disease Relevance 0.09 Pain Relevance 0
The drug's stimulation of 5-HT4 receptors on intestinal enterocytes increases peristaltic activity and fluid secretion into the gut lumen, facilitating stool passage.
Positive_regulation (increases) of Positive_regulation (stimulation) of 5-HT4 in enterocytes
2) Confidence 0.49 Published 2007 Journal Pharmacotherapy Section Abstract Doc Link 17253916 Disease Relevance 0.57 Pain Relevance 0.59

General Comments

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